iPTMnet Report for Q08462 (ADCY2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08462 / ADCY2_HUMAN
Protein Name Adenylate cyclase type 2
Gene Name Name: ADCY2
Synonyms:KIAA1060;
Organism Homo sapiens (Human)

PRO ID PR:Q08462
DAG View
PRO Name adenylate cyclase type 2 (human)
Definition An adenylate cyclase type 2 that is encoded in the genome of human.
Short Label hADCY2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08462 (ADCY2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y282 Phosphorylation PhosphoSitePlus
Y452 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
T539 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
S933 Phosphorylation PhosphoSitePlus
K937 Ubiquitination PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y282 N282 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y452 H452 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S472 I472 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S472 G472 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S544 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S659 T659 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S659 Y659 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S933 I933 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K937 R937 Biomuta DOID:9256 / colorectal cancer [ cosmic ]