iPTMnet Report for Q08426 (EHHADH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08426 / ECHP_HUMAN
Protein Name Peroxisomal bifunctional enzyme
Gene Name Name: EHHADH
Synonyms:ECHD;
Organism Homo sapiens (Human)

PRO ID PR:Q08426
DAG View
PRO Name peroxisomal bifunctional enzyme (human)
Definition A peroxisomal bifunctional enzyme that is encoded in the genome of human.
Short Label hEHHADH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08426 (EHHADH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T26 Phosphorylation PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
K165 Acetylation PhosphoSitePlus   UniProt 20167786
K171 Acetylation PhosphoSitePlus   UniProt 20167786
S189 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
K280 Acetylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K346 Acetylation PhosphoSitePlus   UniProt 20167786
S359 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S367 Phosphorylation PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
K532 Acetylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus   UniProt 24275569
K577 Acetylation PhosphoSitePlus
Y580 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
K584 Acetylation PhosphoSitePlus   UniProt 19608861, 20167786
K598 Acetylation PhosphoSitePlus
Y666 Phosphorylation PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus   UniProt 23186163
K722 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S359 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T26 A26 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T26 M26 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K56 T56 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K56 E56 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y243 D243 Biomuta DOID:4159 / skin cancer [ cosmic ]
S282 T282 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S299 T299 Biomuta DOID:3571 / liver cancer [ cosmic ]
S367 L367 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
K464 T464 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K532 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y580 C580 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S703 F703 Biomuta DOID:1324 / lung cancer [ cosmic ]
S703 P703 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S718 F718 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]