Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08345 / DDR1_HUMAN
Protein Name Epithelial discoidin domain-containing receptor 1 precursor
Gene Name Name: DDR1
Synonyms:CAK,EDDR1,NEP,NTRK4,PTK3A,RTK6,TRKE;
Organism Homo sapiens (Human)

PRO ID PR:Q08345
DAG View
PRO Name epithelial discoidin domain-containing receptor 1 (human)
Definition A discoidin domain-containing receptor 1 that is encoded in the genome of human.
Short Label hDDR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08345 (DDR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
N211 N-Glycosylation GlyGen   UniProt 24509848, 22483115
S213 Phosphorylation RLIMS-P 24509848
N260 N-Glycosylation GlyGen   UniProt 24509848, 22483115
N394 N-Glycosylation GlyGen 24509848
K449 Ubiquitination PhosphoSitePlus
T469 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation Q08345 (DDR1) PhosphoSitePlus   RLIMS-P   UniProt 24509848, 29438985
S496 Phosphorylation PhosphoSitePlus
Y513 Phosphorylation Q08345 (DDR1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24509848, 9659899, 24671415, ...28590245
T519 Phosphorylation PhosphoSitePlus
Y520 Phosphorylation Q08345 (DDR1) PhosphoSitePlus   UniProt 24509848
Y569 Phosphorylation PhosphoSitePlus
Y586 Phosphorylation PhosphoSitePlus
K613 Methylation PhosphoSitePlus
K615 Methylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus   UniProt 19369195
K646 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
T701 Phosphorylation PhosphoSitePlus
Y703 Phosphorylation PhosphoSitePlus
Y740 Phosphorylation Q08345 (DDR1) IntAct   PhosphoSitePlus   UniProt 16337946
S788 Phosphorylation Q9HC98 (NEK6) neXtProt   phospho.ELM   PhosphoSitePlus 12023960
Y792 Phosphorylation Q08345 (DDR1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24768818, 18083107, 24671415, ...24509848, 31979355
Y796 Phosphorylation Q08345 (DDR1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 24768818, 24509848, ...24671415
Y797 Phosphorylation Q08345 (DDR1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 24768818, 24509848, ...24671415
T912 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y484 Phosphorylation IntAct 22057045
Y513 Phosphorylation Q08345 (DDR1) HPRD   IntAct 9659899, 22057045
Y520 Phosphorylation IntAct 22057045
Y543 Phosphorylation IntAct 22057045
Y547 Phosphorylation IntAct 22057045
Y569 Phosphorylation IntAct 22057045
Y586 Phosphorylation IntAct 22057045
Y703 Phosphorylation IntAct 22057045
Y740 Phosphorylation IntAct 22057045
Y756 Phosphorylation IntAct 22057045
Y792 Phosphorylation HPRD   IntAct 18083107, 22057045
Y796 Phosphorylation HPRD   IntAct 18083107, 22057045
Y797 Phosphorylation HPRD   IntAct 18083107, 22057045
Y869 Phosphorylation IntAct 22057045
Y881 Phosphorylation IntAct 22057045
Site PTM Type PTM Enzyme Score Source PMID
T664 Phosphorylation PhosphoSitePlus
Y755 Phosphorylation HPRD 18083107
Y759 Phosphorylation HPRD 18083107
Y760 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
Y513 Phosphorylation Q08345 (DDR1) HPRD 9659899
Y798 Phosphorylation HPRD 18083107
Y802 Phosphorylation HPRD 18083107
Y803 Phosphorylation HPRD 18083107


Q08345 (DDR1) as PTM Enzyme



Substrate Site Score Source PMID
Q08345 (DDR1) Y484 UniProt 24509848
Q08345 (DDR1) Y513 HPRD   Signor   UniProt 24509848, 9659899
Q08345 (DDR1) Y520 UniProt 24509848
Q08345 (DDR1) Y740 UniProt 16337946
Q08345 (DDR1) Y792 UniProt 24509848
Q08345 (DDR1) Y796 UniProt 24509848
Q08345 (DDR1) Y797 UniProt 24509848


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q08345 (DDR1) Y569 P12931 (SRC) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y586 P07948 (LYN) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y569 P16333 (NCK1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y569 P52735 (VAV2) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y569 O43639 (NCK2) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y881 P42338 (PIK3CB) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y881 Q92569 (PIK3R3) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y881 O00329 (PIK3CD) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y881 O00459 (PIK3R2) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y881 P42336 (PIK3CA) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y881 Q92835 (INPP5D) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y869 P42224 (STAT1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y869 Q08345 (DDR1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y869 P40763 (STAT3) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y869 P51692 (STAT5B) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y792 P15311 (EZR) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y792 P20936 (RASA1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y792 P27986 (PIK3R1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y740 Q06124 (PTPN11) unknown eFIP 16337946
Phosphorylation Q08345 (DDR1) Y484 P19174 (PLCG1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y484 Q9UKW4 (VAV3) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y484 P46108 (CRK) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y484 O15357 (INPPL1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y740 P29353 (SHC1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y586 P07947 (YES1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y586 Q06124 (PTPN11) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y586 P41240 (CSK) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y586 Q8WX93 (PALLD) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y586 Q9Y490 (TLN1) unknown eFIP 22057045
Phosphorylation Q08345 (DDR1) Y569 P06241 (FYN) unknown eFIP 22057045


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S213 C213 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S496 F496 Biomuta DOID:1909 / melanoma [ icgc, tcga ]