iPTMnet Report for Q08211 (DHX9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08211 / DHX9_HUMAN
Protein Name ATP-dependent RNA helicase A
Gene Name Name: DHX9
Synonyms:DDX9;
Organism Homo sapiens (Human)

PRO ID PR:Q08211
DAG View
PRO Name ATP-dependent RNA helicase A (human)
Definition An ATP-dependent RNA helicase A that is encoded in the genome of human.
Short Label hDHX9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08211 (DHX9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Sumoylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
Y9 Phosphorylation PhosphoSitePlus
C12 S-Nitrosylation dbSNO 26338901, 22178444, 20140087
K14 Acetylation PhosphoSitePlus
K14 Methylation PhosphoSitePlus
K16 Acetylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
Y21 Phosphorylation PhosphoSitePlus
R24 Methylation PhosphoSitePlus
C36 Methylation IEDB 31844290
S59 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
K76 Sumoylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S87 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 20068231, ...24275569
T92 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T94 Phosphorylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
T108 Phosphorylation phospho.ELM 18669648
K120 Sumoylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus   UniProt 23186163
S130 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K146 Methylation PhosphoSitePlus   UniProt 24129315
K146 Ubiquitination PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
R151 Methylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
K191 Acetylation PhosphoSitePlus   UniProt 19608861
K191 Methylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K199 Acetylation PhosphoSitePlus   UniProt 19608861
K199 Ubiquitination PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
Y259 Phosphorylation PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K275 Sumoylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S321 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648
K391 Acetylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K392 Acetylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
R434 Methylation PhosphoSitePlus
C438 S-Nitrosylation dbSNO 26338901
T443 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus   UniProt 23186163
S452 Phosphorylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
K497 Acetylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus   UniProt 23186163
C608 S-Nitrosylation dbSNO 26338901
C612 S-Nitrosylation dbSNO 26338901
S625 Phosphorylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
K697 Sumoylation PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
T707 Phosphorylation PhosphoSitePlus
K737 Acetylation PhosphoSitePlus
T740 Phosphorylation PhosphoSitePlus
Y748 Phosphorylation PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
T787 Phosphorylation PhosphoSitePlus
T796 Phosphorylation PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
T849 Phosphorylation PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
K943 Acetylation PhosphoSitePlus
K957 Ubiquitination PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
K1024 Acetylation PhosphoSitePlus   UniProt 19608861
K1024 Methylation PhosphoSitePlus
K1024 Ubiquitination PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
C1029 S-Nitrosylation dbSNO 20140087, 22178444
S1032 Phosphorylation PhosphoSitePlus
S1033 Phosphorylation PhosphoSitePlus
K1037 Acetylation PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
Y1038 Phosphorylation PhosphoSitePlus
S1040 Phosphorylation PhosphoSitePlus
K1048 Acetylation PhosphoSitePlus
K1048 Ubiquitination PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
T1063 Phosphorylation PhosphoSitePlus
K1073 Ubiquitination PhosphoSitePlus
K1074 Acetylation PhosphoSitePlus
K1074 Ubiquitination PhosphoSitePlus
S1077 Phosphorylation PhosphoSitePlus
C1099 Methylation IEDB 31844290
K1116 Ubiquitination PhosphoSitePlus
S1142 O-Glycosylation GlyGen 23301498, 30444036, 34725712, ...30397120, 32522876, 26853435, 33214551, 29351928, 34019948, 35083852, 32119511, 22121020, 33465208
S1152 O-Glycosylation GlyGen 23301498, 30444036, 34725712, ...30397120, 32522876, 26853435, 33214551, 29351928, 34019948, 35083852, 32119511, 22121020, 33465208
T1153 O-Glycosylation GlyGen 23301498, 30444036, 34725712, ...30397120, 32522876, 26853435, 33214551, 29351928, 34019948, 35083852, 32119511, 22121020, 33465208
Y1155 Phosphorylation PhosphoSitePlus
R1160 Methylation PhosphoSitePlus
K1163 Acetylation PhosphoSitePlus
K1163 Ubiquitination PhosphoSitePlus
R1166 Methylation PhosphoSitePlus
Y1167 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
Y1173 Phosphorylation PhosphoSitePlus
R1174 Methylation PhosphoSitePlus
R1175 Methylation PhosphoSitePlus   UniProt 24129315
Y1194 Phosphorylation PhosphoSitePlus
R1207 Methylation PhosphoSitePlus
Y1210 Phosphorylation PhosphoSitePlus
R1219 Methylation PhosphoSitePlus
R1223 Methylation PhosphoSitePlus
R1227 Methylation PhosphoSitePlus
Y1234 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
R1235 Methylation PhosphoSitePlus
Y1241 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
R1242 Methylation PhosphoSitePlus
R1249 Methylation PhosphoSitePlus
R1253 Methylation PhosphoSitePlus
R1265 Methylation IEDB   PhosphoSitePlus 28649982, 25880248
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation HPRD 20068231
S87 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
T92 Phosphorylation HPRD 18669648
T108 Phosphorylation HPRD 18669648
Y148 Phosphorylation HPRD 19901323
S163 Phosphorylation HPRD 20068231
T177 Phosphorylation HPRD 20068231
Y251 Phosphorylation HPRD 20068231
S321 Phosphorylation HPRD 18077418, 17525332, 18669648, ...20068231
S449 Phosphorylation HPRD 20068231
S452 Phosphorylation HPRD 20068231
T790 Phosphorylation HPRD 20068231
S1139 Phosphorylation HPRD 20068231
S1142 Phosphorylation HPRD 20068231
S1152 Phosphorylation HPRD 20068231
T1153 Phosphorylation HPRD 20068231
Y1155 Phosphorylation HPRD 20068231
Y1234 Phosphorylation HPRD 17081983
Y1241 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K5 N5 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
C12 Y12 Biomuta [ cosmic ]
R24 G24 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C36 Y36 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S125 F125 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R151 K151 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S241 F241 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S279 C279 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S305 F305 Biomuta DOID:184 / bone cancer [ cosmic ]
K392 T392 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K417 E417 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S506 G506 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S625 C625 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y748 C748 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T849 A849 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1026 Y1026 Biomuta DOID:363 / uterine cancer [ icgc ]
K1037 E1037 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1057 I1057 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K1073 N1073 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1142 L1142 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R1166 G1166 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1171 N1171 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R1207 Q1207 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1207 P1207 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1210 C1210 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R1223 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
R1249 Q1249 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]