Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08209 / PP2BA_HUMAN
Protein Name Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Name Name: PPP3CA
Synonyms:CALNA,CNA;
Organism Homo sapiens (Human)

PRO ID PR:Q08209
DAG View
PRO Name serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (human)
Definition A serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform that is encoded in the genome of human.
Short Label hPPP3CA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08209 (PPP3CA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 Phosphorylation PhosphoSitePlus
R16 Methylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
T427 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus   UniProt 23186163
S498 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S438 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000026140 (hBAD/iso:2/Phos:1) Interaction PR:Q08209 (hPPP3CA) PRO 10195903
PR:000026140 (hBAD/iso:2/Phos:1) Interaction PR:Q08209 (hPPP3CA) PRO 10195903
PR:000026140 (hBAD/iso:2/Phos:1) Interaction PR:Q08209 (hPPP3CA) PRO 10195903


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K466 E466 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S492 C492 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S498 F498 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ tcga ]