iPTMnet Report for Q08209 (PPP3CA)
Protein Information
| UniProt AC / UniProt ID | Q08209 / PP2BA_HUMAN |
| Protein Name | Protein phosphatase 3 catalytic subunit alpha |
| Gene Name | Name: PPP3CA Synonyms:CALNA,CNA; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q08209 |
| PRO Name | protein phosphatase 3 catalytic subunit alpha (human) |
| Definition | A protein phosphatase 3 catalytic subunit alpha that is encoded in the genome of human. |
| Short Label | hPPP3CA |
| Category | organism-gene |
DAG ViewQ08209 (PPP3CA) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Acetylation | score1 | UniProt | 22814378 | ||
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R16 | Methylation | score1 | PhosphoSitePlus | |||
| K32 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K47 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y119 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y159 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K293 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K323 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S411 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K424 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T427 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S462 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K466 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K474 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S492 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S498 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S512 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S515 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S518 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S438 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K441 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q96GX8 (C16orf74) | T44 | Q08209 (PPP3CA) | unknown | eFIP | 28881575 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000026140 (hBAD/iso:2/Phos:1) | Interaction | PR:Q08209 (hPPP3CA) | PRO | 10195903 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R16 | M16 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
| K466 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K466 | E466 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K474 | N474 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S492 | C492 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S498 | F498 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] |
