iPTMnet Report for Q08174 (PCDH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08174 / PCDH1_HUMAN
Protein Name Protocadherin-1 precursor
Gene Name Name: PCDH1
Organism Homo sapiens (Human)

PRO ID PR:Q08174
DAG View
PRO Name protocadherin-1 (human)
Definition A protocadherin-1 that is encoded in the genome of human.
Short Label hPCDH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08174 (PCDH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y81 Phosphorylation PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
N305 N-Glycosylation GlyGen   UniProt 23090970, 19159218, 24190977
S446 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S795 Phosphorylation PhosphoSitePlus
N813 N-Glycosylation GlyGen   UniProt 19159218
N818 N-Glycosylation GlyGen   UniProt 19159218
K891 Acetylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
Y897 Phosphorylation PhosphoSitePlus
K900 Ubiquitination PhosphoSitePlus
S902 Phosphorylation PhosphoSitePlus
K914 Acetylation PhosphoSitePlus
K917 Acetylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus   UniProt 21406692
K920 Ubiquitination PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
K935 Ubiquitination PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus
K938 Acetylation PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus   UniProt 18669648
Y958 Phosphorylation PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692
Y969 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
S973 Phosphorylation PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus   UniProt 21406692
S986 Phosphorylation PhosphoSitePlus
S988 Phosphorylation PhosphoSitePlus
S1014 Phosphorylation PhosphoSitePlus
Y1017 Phosphorylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus
Y1020 Phosphorylation PhosphoSitePlus
Y1022 Phosphorylation PhosphoSitePlus
Y1029 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus
T1042 Phosphorylation PhosphoSitePlus
Y1050 Phosphorylation PhosphoSitePlus
T1056 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S949 Phosphorylation HPRD 18669648
S962 Phosphorylation HPRD 18669648
S973 Phosphorylation HPRD 19664995
S984 Phosphorylation HPRD 15345747, 19664995
Site PTM Type PTM Enzyme Score Source PMID
T249 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
Y897 Phosphorylation PhosphoSitePlus
S949 Phosphorylation HPRD 18669648
S962 Phosphorylation HPRD 18669648
S973 Phosphorylation HPRD 19664995
S984 Phosphorylation HPRD 15345747, 19664995
Y1017 Phosphorylation PhosphoSitePlus
Y1020 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
Y1058 Phosphorylation PhosphoSitePlus
Y1059 Phosphorylation PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
T1068 Phosphorylation PhosphoSitePlus
Y1089 Phosphorylation PhosphoSitePlus
S1097 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus
Y1158 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation HPRD   PhosphoSitePlus 19664994
S1192 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y81 H81 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S114 Y114 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T249 I249 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S262 T262 Biomuta DOID:1324 / lung cancer [ cosmic ]
S262 C262 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S262 N262 Biomuta DOID:4159 / skin cancer [ cosmic ]
S531 G531 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S544 C544 Biomuta DOID:1324 / lung cancer [ cosmic ]
K914 N914 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K920 E920 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K920 N920 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y958 S958 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y969 F969 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S973 F973 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1014 F1014 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1018 F1018 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1089 C1089 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1171 I1171 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1192 I1192 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:3953 / adrenal gland cancer [ cosmic ]