iPTMnet Report for Q08050 (FOXM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08050 / FOXM1_HUMAN
Protein Name Forkhead box protein M1
Gene Name Name: FOXM1
Synonyms:FKHL16,HFH11,MPP2,WIN;
Organism Homo sapiens (Human)

PRO ID PR:Q08050
DAG View
PRO Name forkhead box protein M1 (human)
Definition A forkhead box protein M1 that is encoded in the genome of human.
Short Label hFOXM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08050 (FOXM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) neXtProt   PhosphoSitePlus   Signor 22094256
S35 Phosphorylation P11802 (CDK4) , Q00534 (CDK6) neXtProt   PhosphoSitePlus 22094256
S41 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
S101 O-Glycosylation GlyGen 30620550
K189 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
K201 Sumoylation PhosphoSitePlus
K218 Sumoylation PhosphoSitePlus
S251 Phosphorylation P06493 (CDK1) RLIMS-P   Signor 19737929
K278 Methylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K282 Methylation PhosphoSitePlus
S331 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 26279295
T354 Phosphorylation PhosphoSitePlus
K356 Sumoylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S376 Phosphorylation O96017 (CHEK2) neXtProt   Signor   UniProt 17101782
K422 Acetylation PhosphoSitePlus
K422 Sumoylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K440 Acetylation PhosphoSitePlus
K440 Sumoylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
S451 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) PhosphoSitePlus 22094256
K460 Sumoylation PhosphoSitePlus
K478 Sumoylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
S489 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) PhosphoSitePlus 22094256
K495 Sumoylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
S508 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) PhosphoSitePlus 22094256
T510 Phosphorylation P11802 (CDK4) , Q00534 (CDK6) PhosphoSitePlus 22094256
Y517 Phosphorylation PhosphoSitePlus
S522 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) PhosphoSitePlus   UniProt 22094256, 23186163
T524 Phosphorylation PhosphoSitePlus
S589 Phosphorylation IEDB 25880248, 32357974
T600 Phosphorylation P11802 (CDK4) , P06493 (CDK1) , Q00534 (CDK6) PhosphoSitePlus   RLIMS-P 22094256, 23240008
K603 Acetylation PhosphoSitePlus
K603 Sumoylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
T611 Phosphorylation P11802 (CDK4) , P06493 (CDK1) , Q00534 (CDK6) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22094256, 23240008, 19737929, ...19160488
K614 Acetylation PhosphoSitePlus
T620 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22094256, 23240008, 18669648
S623 Phosphorylation PhosphoSitePlus
T627 Phosphorylation P11802 (CDK4) , Q00534 (CDK6) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 22094256, 18669648
S638 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus   UniProt 19160488
S704 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) phospho.ELM   PhosphoSitePlus   RLIMS-P 26279295, 15302935, 22094256
S717 Phosphorylation PhosphoSitePlus
T719 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S730 Phosphorylation P53350 (PLK1) phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 18669648, 19737929, 20068231, ...19160488
S739 Phosphorylation P53350 (PLK1) PRO   PhosphoSitePlus   Signor   UniProt 19737929, 20068231, 19160488
Site PTM Type PTM Enzyme Score Source PMID
S331 Phosphorylation HPRD 18669648
T611 Phosphorylation P24941 (CDK2) , P06493 (CDK1) HPRD 15024056
T620 Phosphorylation HPRD 18669648
T627 Phosphorylation HPRD 18669648
S704 Phosphorylation HPRD 15302935
S717 Phosphorylation HPRD 19651622, 18691976, 20068231, ...18452278
T719 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S730 Phosphorylation HPRD 19651622, 18669648, 20068231
S739 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S191 Phosphorylation PhosphoSitePlus
K201 Sumoylation PhosphoSitePlus
K218 Sumoylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
K341 Sumoylation PhosphoSitePlus
S361 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 17101782
K445 Sumoylation PhosphoSitePlus
K463 Sumoylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
K480 Sumoylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
T596 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 15024056, 19737929
T605 Phosphorylation HPRD 18669648
T612 Phosphorylation HPRD 18669648
S623 Phosphorylation PhosphoSitePlus
S689 Phosphorylation HPRD 15302935
S702 Phosphorylation HPRD 19651622, 18691976, 20068231, ...18452278
T704 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S715 Phosphorylation HPRD 19651622, 18669648, 20068231
S724 Phosphorylation HPRD   PhosphoSitePlus 20068231
Site PTM Type PTM Enzyme Score Source PMID
S331 Phosphorylation HPRD 18669648
T649 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD 15024056
T658 Phosphorylation HPRD 18669648
T665 Phosphorylation HPRD 18669648
S742 Phosphorylation HPRD 15302935
S755 Phosphorylation HPRD 19651622, 18691976, 20068231, ...18452278
T757 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S768 Phosphorylation HPRD 19651622, 18669648, 20068231
S777 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047444 (hFOXM1/Phos:1) pT611 PRO
PR:000047445 (hFOXM1/Phos:2) pT611,pS730,pS739 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q08050 (FOXM1) T600 P30304 (CDC25A) increased_association eFIP 23240008


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 C41 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K201 N201 Biomuta DOID:363 / uterine cancer [ icgc ]
T357 A357 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K422 N422 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T510 N510 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T524 S524 Biomuta DOID:3571 / liver cancer [ cosmic ]
S566 C566 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S567 F567 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S589 N589 Biomuta DOID:3571 / liver cancer [ cosmic ]
S610 T610 Biomuta [ cosmic ]
S724 N724 Biomuta DOID:184 / bone cancer [ cosmic ]
S739 N739 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]
S777 N777 Biomuta DOID:184 / bone cancer [ cosmic ]