iPTMnet Report for Q07973 (CYP24A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07973 / CP24A_HUMAN
Protein Name 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor
Gene Name Name: CYP24A1
Synonyms:CYP24;
Organism Homo sapiens (Human)

PRO ID PR:Q07973
DAG View
PRO Name 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (human)
Definition A 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial that is encoded in the genome of human.
Short Label hCYP24A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07973 (CYP24A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
K165 Acetylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y125 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y220 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T388 M388 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T395 S395 Biomuta DOID:4159 / skin cancer [ cosmic ]