iPTMnet Report for Q07955 (SRSF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07955 / SRSF1_HUMAN
Protein Name Serine/arginine-rich splicing factor 1
Gene Name Name: SRSF1
Synonyms:ASF,SF2,SF2P33,SFRS1;ORFNames:OK/SW-cl.3;
Organism Homo sapiens (Human)

PRO ID PR:Q07955
DAG View
PRO Name serine/arginine-rich splicing factor 1 (human)
Definition A splicing factor, arginine/serine-rich 1 that is encoded in the genome of human.
Short Label hSRSF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07955 (SRSF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692
S2 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983
Y19 Phosphorylation PhosphoSitePlus   RLIMS-P 30320932
T29 Phosphorylation PhosphoSitePlus
K30 Acetylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
K38 Acetylation PhosphoSitePlus   UniProt 19608861
K38 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
R51 Methylation PhosphoSitePlus
R65 Methylation PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
Y79 Phosphorylation PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
R90 Methylation PhosphoSitePlus
R93 Methylation PhosphoSitePlus   UniProt 24129315, 20308322
R97 Methylation PhosphoSitePlus   UniProt 24129315, 20308322
R109 Methylation PhosphoSitePlus   UniProt 24129315, 20308322
R111 Methylation PhosphoSitePlus   UniProt 24129315
Y112 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 22393468
S119 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 22393468
S133 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 32453427
K138 Acetylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
C148 Methylation IEDB 31844290
Y149 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K179 Acetylation PhosphoSitePlus   UniProt 19608861
K179 Ubiquitination PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
R191 Methylation PhosphoSitePlus
S199 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 17287340, 20068231
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 24449914, ...24275569, 23186163
Y202 Phosphorylation PhosphoSitePlus   UniProt 24275569
S205 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 18669648, ...18155240, 23186163
S205 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S207 Phosphorylation PhosphoSitePlus   UniProt 18155240, 24449914
S207 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S209 Phosphorylation PhosphoSitePlus   UniProt 18155240, 24449914
S209 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S211 Phosphorylation PhosphoSitePlus 18155240
S211 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S213 Phosphorylation PhosphoSitePlus 18155240
S213 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S215 Phosphorylation PhosphoSitePlus 18155240
S215 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S217 Phosphorylation PhosphoSitePlus 18155240
S217 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S219 Phosphorylation PhosphoSitePlus 18155240
S219 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S221 Phosphorylation PhosphoSitePlus 18155240
S221 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S223 Phosphorylation PhosphoSitePlus 18155240
S223 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S225 Phosphorylation PhosphoSitePlus 18155240
S225 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
Y226 Phosphorylation PhosphoSitePlus
S227 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 18155240, 18658135, 9731229
S227 Phosphorylation Q13627 (DYRK1A) neXtProt 18658135
S227 Phosphorylation Q96SB4 (SRPK1) PhosphoSitePlus 18155240
S231 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S234 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 18658135
S234 Phosphorylation Q13627 (DYRK1A) neXtProt 18658135
Y237 Phosphorylation PhosphoSitePlus
S238 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 17081983, 18658135
S238 Phosphorylation Q13627 (DYRK1A) neXtProt   Signor 18658135
S242 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S244 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 17081983, 20068231
Y189 Phosphorylation HPRD 15592455
S199 Phosphorylation HPRD 17322306, 17287340, 18767875, ...19664995, 19651622, 18669648, 18707149, 20166139, 17924679, 19415658, 20068231, 20068230
S201 Phosphorylation HPRD 17322306, 17287340, 18767875, ...19651622, 18669648, 20166139, 20068231
Y202 Phosphorylation HPRD 17322306, 18767875, 18669648, ...20166139, 19651622
S205 Phosphorylation HPRD 17287340, 17081983, 18767875, ...19651622, 18669648, 20068231
S225 Phosphorylation HPRD 17081983
Y226 Phosphorylation HPRD 17081983, 20068231
S227 Phosphorylation HPRD 17081983, 20068231
S231 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S234 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
Y237 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 20068231
S238 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 20068231
S242 Phosphorylation HPRD 20068231
S244 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R51 C51 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc, tcga ]
Y72 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y77 N77 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y82 * Biomuta DOID:263 / kidney cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R97 Q97 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R97 G97 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
R97 L97 Biomuta DOID:1324 / lung cancer [ cosmic ]
S133 C133 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K138 N138 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T187 I187 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y189 H189 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S213 N213 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S234 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S238 F238 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S244 Y244 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T248 A248 Biomuta DOID:10534 / stomach cancer [ cosmic ]