iPTMnet Report for Q07954 (LRP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07954 / LRP1_HUMAN
Protein Name Prolow-density lipoprotein receptor-related protein 1 precursor
Gene Name Name: LRP1
Synonyms:A2MR,APR;
Organism Homo sapiens (Human)

PRO ID PR:Q07954
DAG View
PRO Name prolow-density lipoprotein receptor-related protein 1 (human)
Definition A low-density lipoprotein receptor-related protein 1 that is encoded in the genome of human.
Short Label hLRP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07954 (LRP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N136 N-Glycosylation GlyGen 29741879
N239 N-Glycosylation GlyGen 29741879
K336 Ubiquitination PhosphoSitePlus
N357 N-Glycosylation GlyGen 29741879
N446 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 29391424, 29741879
K458 Methylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
Y530 Phosphorylation PhosphoSitePlus
R539 Methylation PhosphoSitePlus
T648 Phosphorylation PhosphoSitePlus
N729 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 29391424, 19139490, 29741879
S847 O-Glycosylation GlyGen 30459171
T894 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S897 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T935 O-Glycosylation GlyGen 30459171
T975 O-Glycosylation GlyGen 30459171
S1014 O-Glycosylation GlyGen 30459171
T1056 O-Glycosylation GlyGen 30459171
T1101 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S1417 Phosphorylation PhosphoSitePlus
S1419 Phosphorylation PhosphoSitePlus
T1430 Phosphorylation PhosphoSitePlus
S1432 Phosphorylation PhosphoSitePlus
T1440 Phosphorylation PhosphoSitePlus
Y1443 Phosphorylation PhosphoSitePlus
T1498 Phosphorylation PhosphoSitePlus
T1500 Phosphorylation PhosphoSitePlus
N1511 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 23090970, ...29391424, 19139490, 29741879
T1513 Phosphorylation PhosphoSitePlus
N1575 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...29391424, 24190977
Y1587 Phosphorylation PhosphoSitePlus
N1616 N-Glycosylation GlyGen   UniProt 29741879, 19159218
N1645 N-Glycosylation GlyGen   UniProt 29741879, 19159218
N1733 N-Glycosylation GlyGen 29391424
S1754 Phosphorylation PhosphoSitePlus
N1763 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...29391424, 24190977
N1767 N-Glycosylation GlyGen 23090970, 24190977
K1788 Acetylation PhosphoSitePlus
T1790 Phosphorylation PhosphoSitePlus
N1825 N-Glycosylation GlyGen 23090970, 29741879, 29391424, ...24190977
N1995 N-Glycosylation GlyGen 29741879, 29391424
N2048 N-Glycosylation GlyGen 29391424
N2117 N-Glycosylation GlyGen 29741879, 29391424, 24190977
N2127 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 29391424, 29741879
T2156 Phosphorylation PhosphoSitePlus
N2157 N-Glycosylation GlyGen 29391424
Y2290 Phosphorylation PhosphoSitePlus
N2472 N-Glycosylation GlyGen 29741879
N2502 N-Glycosylation GlyGen 23090970, 24190977
S2559 Phosphorylation PhosphoSitePlus
Y2560 Phosphorylation PhosphoSitePlus
S2563 Phosphorylation PhosphoSitePlus
R2577 Methylation PhosphoSitePlus
N2601 N-Glycosylation GlyGen 29741879
N2620 N-Glycosylation GlyGen 23090970, 29741879, 24190977
S2621 Phosphorylation PhosphoSitePlus
N2638 N-Glycosylation GlyGen 29741879
T2773 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
N2815 N-Glycosylation GlyGen   UniProt 19159218
T2857 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
N2905 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N2942 N-Glycosylation GlyGen 29391424
N3048 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 29391424, 29741879
N3089 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 29391424, ...19159218, 24190977
N3092 N-Glycosylation GlyGen 24190977
S3142 Phosphorylation PhosphoSitePlus
T3261 Phosphorylation PhosphoSitePlus
N3303 N-Glycosylation GlyGen 29391424
N3333 N-Glycosylation GlyGen 23090970, 29741879, 24190977
T3452 O-Glycosylation GlyGen 30459171
N3488 N-Glycosylation GlyGen   UniProt 29741879, 19159218
T3493 O-Glycosylation GlyGen 30459171
R3500 Methylation PhosphoSitePlus
T3535 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
T3571 O-Glycosylation GlyGen 30459171
N3662 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N3663 N-Glycosylation GlyGen 24190977
T3735 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N3788 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 29391424, ...19159218, 24190977
N3839 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N3840 N-Glycosylation GlyGen 24190977
N3858 N-Glycosylation GlyGen 29391424
S3928 Phosphorylation PhosphoSitePlus
N3953 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 29391424, ...19159218, 24190977
K3988 Acetylation PhosphoSitePlus
S4067 Phosphorylation PhosphoSitePlus
S4071 Phosphorylation PhosphoSitePlus
N4075 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...29391424, 24190977
N4125 N-Glycosylation GlyGen   UniProt 19159218
N4149 N-Glycosylation GlyGen 29391424
S4249 Phosphorylation PhosphoSitePlus
T4362 O-Glycosylation GlyGen 30237853
N4364 N-Glycosylation GlyGen 23090970, 30237853, 24190977
K4452 Ubiquitination PhosphoSitePlus
T4460 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor   UniProt 15272003
Y4473 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 18381291
Y4507 Phosphorylation P12931 (SRC) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18381291, 11854294, 12789267, ...21968187
Y4511 Phosphorylation PhosphoSitePlus
S4517 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   Signor   UniProt 15272003, 11158305
S4520 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12069755, 11158305, 15272003, ...24275569
S4523 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor   UniProt 15272003
K4527 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N729 N-Glycosylation PRO 29741879
T1500 Phosphorylation HPRD 18491316
T1513 Phosphorylation HPRD 18491316
N2117 N-Glycosylation PRO 29741879
S3217 Phosphorylation HPRD 20068231
Y4507 Phosphorylation P12931 (SRC) HPRD 11854294, 12789267
S4520 Phosphorylation P17612 (PRKACA) HPRD 19651622, 11158305
S4523 Phosphorylation HPRD 19651622


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P29317 (EPHA2) S897 Q07954 (LRP1) unknown eFIP 21408136


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N136 I136 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S511 G511 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y530 H530 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R539 Q539 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R539 W539 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R539 L539 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S897 L897 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S897 P897 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
N1575 Y1575 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N2048 K2048 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
N2117 S2117 Biomuta DOID:10283 / prostate cancer [ cosmic ]
N2117 I2117 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2559 P2559 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2563 F2563 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2563 Y2563 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R2577 C2577 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S2621 Y2621 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2773 M2773 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S3217 N3217 Biomuta DOID:9256 / colorectal cancer [ icgc ]
N3303 Y3303 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R3500 C3500 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R3500 S3500 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N3663 S3663 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K3988 N3988 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S4523 R4523 Biomuta DOID:3571 / liver cancer [ cosmic ]