iPTMnet Report for Q07890 (SOS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07890 / SOS2_HUMAN
Protein Name Son of sevenless homolog 2
Gene Name Name: SOS2
Organism Homo sapiens (Human)

PRO ID PR:Q07890
DAG View
PRO Name son of sevenless homolog 2 (human)
Definition A son of sevenless homolog 2 that is encoded in the genome of human.
Short Label hSOS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07890 (SOS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K76 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
C370 Methylation IEDB 31844290
Y389 Phosphorylation PhosphoSitePlus
Y392 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K470 Acetylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
Y616 Phosphorylation PhosphoSitePlus
K658 Acetylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
Y679 Phosphorylation PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus
Y794 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
R846 Methylation PhosphoSitePlus
R852 Methylation PhosphoSitePlus
K949 Methylation PhosphoSitePlus
K949 Ubiquitination PhosphoSitePlus
K958 Methylation PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
Y1006 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
T1030 Phosphorylation PhosphoSitePlus
S1032 Phosphorylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus
S1047 Phosphorylation PhosphoSitePlus
T1048 Phosphorylation PhosphoSitePlus
T1051 Phosphorylation PhosphoSitePlus
T1057 Phosphorylation PhosphoSitePlus
S1128 Phosphorylation PhosphoSitePlus
S1132 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
S1168 Phosphorylation PhosphoSitePlus
S1202 Phosphorylation PhosphoSitePlus
S1258 Phosphorylation PhosphoSitePlus
S1260 Phosphorylation PhosphoSitePlus
T1261 Phosphorylation PhosphoSitePlus
S1267 Phosphorylation PhosphoSitePlus
Y1275 Phosphorylation PhosphoSitePlus
S1315 Phosphorylation PhosphoSitePlus
Y1320 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K76 M76 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y351 * Biomuta DOID:4159 / skin cancer [ cosmic ]
C370 W370 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K663 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y679 F679 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y679 C679 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1006 C1006 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1032 F1032 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1035 F1035 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1051 A1051 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1128 F1128 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1128 Y1128 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1168 P1168 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1168 C1168 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1315 L1315 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1320 H1320 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]