iPTMnet Report for Q07866 (KLC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07866 / KLC1_HUMAN
Protein Name Kinesin light chain 1
Gene Name Name: KLC1
Synonyms:KLC,KNS2;
Organism Homo sapiens (Human)

PRO ID PR:Q07866
DAG View
PRO Name kinesin light chain 1 (human)
Definition A kinesin light chain 1 that is encoded in the genome of human.
Short Label hKLC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07866 (KLC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y2 Phosphorylation PhosphoSitePlus
Y10 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
C236 Methylation IEDB 31844290
K237 Ubiquitination PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
K272 Acetylation PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
C390 Methylation IEDB 31844290
K393 Acetylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
K454 Methylation PhosphoSitePlus
C456 Methylation IEDB 31844290
S460 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) IEDB   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21385839, 29093025, 28228285, ...22470497
T462 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 29093025, 28228285
T464 Phosphorylation PhosphoSitePlus   RLIMS-P 29093025
T465 Phosphorylation PhosphoSitePlus
T466 Phosphorylation RLIMS-P 29093025
K495 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
R505 Methylation PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
S521 Phosphorylation Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   UniProt 21099273, 20074060
S524 Phosphorylation PhosphoSitePlus   UniProt 20074060
Y532 Phosphorylation PhosphoSitePlus
E547 Phosphorylation UniProt 21406692, 20068231, 24275569
S557 Phosphorylation PhosphoSitePlus
R570 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S162 Phosphorylation HPRD 19651622
S460 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 19664994, 19664995, 19691289, 18669648, 20068231
T462 Phosphorylation HPRD 19413330, 18669648
T466 Phosphorylation HPRD 20068231
S521 Phosphorylation HPRD 19651622, 18669648
S524 Phosphorylation HPRD 19651622, 18669648, 18212344
Site PTM Type PTM Enzyme Score Source PMID
S162 Phosphorylation HPRD 19651622
S460 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 19664994, 19664995, 19691289, 18669648, 20068231
T462 Phosphorylation HPRD 19413330, 18669648
T466 Phosphorylation HPRD 20068231
S521 Phosphorylation HPRD 19651622, 18669648
S524 Phosphorylation HPRD 19651622, 18669648, 18212344, ...20068231
Y532 Phosphorylation PhosphoSitePlus
S545 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y360 Phosphorylation PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
Y532 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
K596 Methylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
T633 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S534 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
K548 Methylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
K587 Methylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
T624 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S546 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S561 Phosphorylation PhosphoSitePlus
K596 Methylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
R621 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y307 F307 Biomuta DOID:1324 / lung cancer [ cosmic ]
T371 A371 Biomuta DOID:1324 / lung cancer [ cosmic ]
C390 F390 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S418 F418 Biomuta DOID:4159 / skin cancer [ cosmic ]
K441 N441 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K441 E441 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y449 H449 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S552 F552 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ]
S557 F557 Biomuta DOID:4159 / skin cancer [ cosmic ]
S561 F561 Biomuta DOID:4159 / skin cancer [ cosmic ]
S568 Y568 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R570 T570 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ]