Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07864 / DPOE1_HUMAN
Protein Name DNA polymerase epsilon catalytic subunit A
Gene Name Name: POLE
Synonyms:POLE1;
Organism Homo sapiens (Human)

PRO ID PR:Q07864
DAG View
PRO Name DNA polymerase epsilon catalytic subunit A (human)
Definition A DNA polymerase epsilon catalytic subunit A that is encoded in the genome of human.
Short Label hPOLE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07864 (POLE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
R197 Methylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
R705 Methylation PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
K969 Ubiquitination PhosphoSitePlus
K1042 Ubiquitination PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
K1058 Ubiquitination PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
K1155 Ubiquitination PhosphoSitePlus
K1162 Ubiquitination PhosphoSitePlus
K1169 Ubiquitination PhosphoSitePlus
K1174 Ubiquitination PhosphoSitePlus
K1182 Ubiquitination PhosphoSitePlus
S1184 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S1201 Phosphorylation HPRD   PhosphoSitePlus 18691976
S1204 Phosphorylation PhosphoSitePlus
S1297 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1317 Phosphorylation PhosphoSitePlus   UniProt 23186163
R1320 Methylation PhosphoSitePlus
K1374 Ubiquitination PhosphoSitePlus
K1550 Ubiquitination PhosphoSitePlus
K1562 Ubiquitination PhosphoSitePlus
T1583 Phosphorylation PhosphoSitePlus
S1590 Phosphorylation PhosphoSitePlus
S1797 Phosphorylation PhosphoSitePlus
S1940 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 20068231
T2023 Phosphorylation PhosphoSitePlus
K2110 Ubiquitination PhosphoSitePlus
K2124 Ubiquitination PhosphoSitePlus
T2215 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y85 C85 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S156 A156 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K425 M425 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S692 P692 Biomuta DOID:363 / uterine cancer [ tcga ]
R705 P705 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R705 W705 Biomuta DOID:363 / uterine cancer [ tcga ]
K1070 N1070 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10283 / prostate cancer [ cosmic ]
K1155 M1155 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K1155 N1155 Biomuta DOID:9256 / colorectal cancer [ icgc ]