iPTMnet Report for Q07812 (BAX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07812 / BAX_HUMAN
Protein Name Apoptosis regulator BAX
Gene Name Name: BAX
Synonyms:BCL2L4;
Organism Homo sapiens (Human)

PRO ID PR:Q07812
DAG View
PRO Name apoptosis regulator BAX (human)
Definition An apoptosis regulator BAX that is encoded in the genome of human.
Short Label hBAX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07812 (BAX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 25944712
R9 Methylation PhosphoSitePlus
S15 Phosphorylation RLIMS-P 16227412, 15851551
K21 Ubiquitination PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
C126 Methylation IEDB 31844290
K128 Ubiquitination UniProt 36361894
T135 Phosphorylation PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
S163 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P   Signor 19182807, 15525785, 20976235
Y164 Phosphorylation RLIMS-P 19182807
T167 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus   RLIMS-P+   RLIMS-P 21769948, 26991014, 33230593, ...19182807, 24113173, 16709574, 29290835, 23348591
T172 Phosphorylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
S184 Phosphorylation Q05513 (PRKCZ) , P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 14766748, 19696224, 29987135, ...26763134, 25230299, 16679323, 24113173, 23348591, 31723205, 20976235, 19182807, 35250564, 15642728, 17525161, 33531986, 30693913
T186 Phosphorylation PhosphoSitePlus
K190 Ubiquitination UniProt 36361894
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S87 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S87 Phosphorylation HPRD 20068231
K163 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S87 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036214 (hBAX/Ac:1) acM1 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P10415 (BCL2) S70 Q07812 (BAX) increased_association eFIP 29433359
Phosphorylation Q07812 (BAX) S184 P04637 (TP53) unknown eFIP 27769050
Phosphorylation Q07812 (BAX) T167 Q13526 (PIN1) unknown eFIP 19182807


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O43521-2 (hBCL2L11/iso:BimL) Interaction PR:Q07812 (hBAX) PRO 14764673
PR:Q07817-1 (hBCL2L1/iso:1) Interaction PR:Q07812 (hBAX) PRO 8596636


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S38 F38 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ]
S87 F87 Biomuta DOID:4159 / skin cancer [ cosmic ]
C126 R126 Biomuta DOID:363 / uterine cancer [ icgc ]
C126 W126 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T135 P135 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K163 E163 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ icgc ]
Y164 H164 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K190 R190 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]