iPTMnet Report for Q07666 (KHDRBS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07666 / KHDR1_HUMAN
Protein Name KH domain-containing, RNA-binding, signal transduction-associated protein 1
Gene Name Name: KHDRBS1
Synonyms:SAM68;
Organism Homo sapiens (Human)

PRO ID PR:Q07666
DAG View
PRO Name KH domain-containing, RNA-binding, signal transduction-associated protein 1 (human)
Definition A KH domain-containing, RNA-binding, signal transduction-associated protein 1 that is encoded in the genome of human.
Short Label hKHDRBS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07666 (KHDRBS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R4 Methylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
S12 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
S12 Phosphorylation IEDB   PhosphoSitePlus 27920218
S14 Phosphorylation PhosphoSitePlus
S15 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
S15 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R17 Methylation PhosphoSitePlus
S18 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
S18 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569, ...18220336
S20 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
S20 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 23186163, 17081983, ...18220336, 18669648
S24 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
S24 Phosphorylation PhosphoSitePlus
S29 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T33 Phosphorylation PhosphoSitePlus   UniProt 23186163
S35 Phosphorylation PhosphoSitePlus
R36 Methylation PhosphoSitePlus
R43 Methylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
R45 Methylation PhosphoSitePlus   UniProt 12529443
R52 Methylation PhosphoSitePlus   UniProt 12529443
S58 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 12478298, 24275569
S58 Phosphorylation P28482 (MAPK1) Signor 12478298
S58 Phosphorylation Q16539 (MAPK14) phospho.ELM 12478298
T61 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T72 Phosphorylation PhosphoSitePlus   Signor 12478298
T72 Phosphorylation P28482 (MAPK1) Signor 12478298
T77 Phosphorylation PhosphoSitePlus
T84 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 12478298
T84 Phosphorylation P28482 (MAPK1) Signor 12478298
T84 Phosphorylation Q16539 (MAPK14) phospho.ELM 12478298
K96 Acetylation PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
K102 Sumoylation PhosphoSitePlus
Y103 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K111 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus   UniProt 23186163
K152 Ubiquitination PhosphoSitePlus
K165 Acetylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K175 Acetylation PhosphoSitePlus   UniProt 19608861
K175 Methylation PhosphoSitePlus
K175 Sumoylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T183 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
T183 Phosphorylation PhosphoSitePlus   UniProt 23186163
K185 Sumoylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K194 Methylation PhosphoSitePlus
K194 Sumoylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K200 Methylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S202 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
S202 Phosphorylation PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
R213 Methylation PhosphoSitePlus
C238 Methylation IEDB 31844290
K252 Acetylation PhosphoSitePlus
K253 Acetylation PhosphoSitePlus
R282 Methylation PhosphoSitePlus   UniProt 24129315
R284 Methylation PhosphoSitePlus   UniProt 24129315
R289 Methylation PhosphoSitePlus
R291 Methylation PhosphoSitePlus
R302 Methylation PhosphoSitePlus
R304 Methylation PhosphoSitePlus   UniProt 12529443
R310 Methylation PhosphoSitePlus   UniProt 12529443
R315 Methylation PhosphoSitePlus   UniProt 12529443
T317 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
T317 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 9315091
T317 Phosphorylation P06493 (CDK1) phospho.ELM   Signor 9315091
R320 Methylation PhosphoSitePlus   UniProt 12529443
T324 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
R325 Methylation PhosphoSitePlus   UniProt 12529443
T330 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
R331 Methylation PhosphoSitePlus   UniProt 24129315
R340 Methylation PhosphoSitePlus   UniProt 24129315, 15782174
R346 Methylation PhosphoSitePlus
R348 Methylation PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus
Y371 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
Y387 Phosphorylation PhosphoSitePlus   UniProt 22000517
S388 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y396 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
S422 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...36580660, 30397120, 30379171, 34725712, 21740066, 35008409, 34019948, 35083852, 32119511, 28510447, 22121020, 33465208
K424 Ubiquitination PhosphoSitePlus
K432 Methylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
Y435 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 16179349, 10913193, 19304789
Y435 Phosphorylation Q13882 (PTK6) neXtProt   Signor 16179349, 10913193, 19304789
Y440 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16179349, 10913193, 19304789
Y440 Phosphorylation Q13882 (PTK6) neXtProt   Signor 16179349, 10913193, 19304789
R442 Methylation PhosphoSitePlus
Y443 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 16179349, 10913193, 19304789
Y443 Phosphorylation Q13882 (PTK6) neXtProt   Signor 16179349, 10913193, 19304789
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 20068230
S15 Phosphorylation HPRD 18669648, 20068230
S18 Phosphorylation HPRD 18691976, 17081983, 19664995, ...18452278, 18669648, 20166139, 20068231, 17924679
S20 Phosphorylation HPRD 16083285, 17287340, 19664995, ...18452278, 18669648, 18707149, 19415658, 20068231
S29 Phosphorylation HPRD 18669648
T33 Phosphorylation HPRD 20068231, 17924679
S35 Phosphorylation HPRD 20068231
S58 Phosphorylation HPRD 18691976, 12478298, 19664995, ...20068231
S58 Phosphorylation P28482 (MAPK1) HPRD 18691976, 12478298, 19664995, ...20068231
T61 Phosphorylation HPRD 18669648, 19664995, 20068231
S70 Phosphorylation HPRD 17081983
T72 Phosphorylation HPRD 17081983
T84 Phosphorylation HPRD 12478298
T84 Phosphorylation P28482 (MAPK1) HPRD 12478298
T92 Phosphorylation HPRD 17081983
Y103 Phosphorylation HPRD 20068231
S202 Phosphorylation HPRD 20068230
T317 Phosphorylation HPRD 9315091
T317 Phosphorylation P06493 (CDK1) HPRD 9315091
T349 Phosphorylation HPRD 20068231
Y435 Phosphorylation HPRD 16179349
Y435 Phosphorylation Q13882 (PTK6) HPRD 16179349
Y440 Phosphorylation HPRD 16179349
Y440 Phosphorylation Q13882 (PTK6) HPRD 16179349
Y443 Phosphorylation HPRD 16179349
Y443 Phosphorylation Q13882 (PTK6) HPRD 16179349


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R10 H10 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S29 L29 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R43 W43 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S44 P44 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R45 W45 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y103 C103 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S113 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T183 I183 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K194 E194 Biomuta DOID:3571 / liver cancer [ cosmic ]
R213 C213 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K252 N252 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K253 T253 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R282 H282 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R284 H284 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R310 Q310 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R315 C315 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R325 K325 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R331 L331 Biomuta DOID:3571 / liver cancer [ cosmic ]
R331 Q331 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R331 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R348 Q348 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R348 W348 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y369 C369 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y375 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y380 C380 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S390 C390 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K424 N424 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y440 S440 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y440 C440 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R442 H442 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]