iPTMnet Report for Q07352 (ZFP36L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q07352 / TISB_HUMAN
Protein Name mRNA decay activator protein ZFP36L1
Gene Name Name: ZFP36L1
Synonyms:BERG36;
Organism Homo sapiens (Human)

PRO ID PR:Q07352
DAG View
PRO Name mRNA decay activator protein ZFP36L1 (human)
Definition An mRNA decay activator protein ZFP36L1 that is encoded in the genome of human.
Short Label hZFP36L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q07352 (ZFP36L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C18 Methylation IEDB 31844290
K22 Ubiquitination PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
C34 Methylation IEDB 31844290
K39 Ubiquitination PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
S54 Phosphorylation P49137 (MAPKAPK2) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 18212344, ...27708140, 18326031, 19651622, 24275569, 18767875, 20166139, 26280535
T56 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K72 Sumoylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27708140, 15538381
S92 Phosphorylation P49137 (MAPKAPK2) , P31749 (AKT1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27708140, 18326031, 26280535, ...15538381
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
C129 Methylation IEDB 31844290
K130 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
R172 Methylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S201 Phosphorylation IEDB   PhosphoSitePlus 27920218
S203 Phosphorylation P49137 (MAPKAPK2) , P31749 (AKT1) IEDB   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17030608, 18326031, 27708140, ...30784271, 26280535, 27869121
S283 Phosphorylation IEDB   PhosphoSitePlus 27869121
S314 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus   UniProt 24275569
S331 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25106868, 27708140
S336 Phosphorylation HPRD   PhosphoSitePlus 17081983


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049726 (hZFP36L1/Phos:1) pS92,pS203 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q07352 (ZFP36L1) S334 Q9NPI6 (DCP1A) unknown eFIP 27708140


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C18 * Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
C18 R18 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T43 I43 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S54 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K61 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S92 L92 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S92 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y115 C115 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K116 E116 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
C129 G129 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C129 Y129 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C129 S129 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K134 T134 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K154 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y169 C169 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y169 H169 Biomuta DOID:263 / kidney cancer [ icgc ]
Y169 S169 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R172 C172 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S201 R201 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S318 F318 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S334 F334 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S336 * Biomuta DOID:1612 / breast cancer [ cosmic ]