iPTMnet Report for Q07002 (CDK18)
Protein Information
| UniProt AC / UniProt ID | Q07002 / CDK18_HUMAN |
| Protein Name | Cyclin-dependent kinase 18 |
| Gene Name | Name: CDK18 Synonyms:PCTAIRE3,PCTK3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q07002 |
| PRO Name | cyclin-dependent kinase 18 (human) |
| Definition | A cyclin-dependent kinase 18 that is encoded in the genome of human. |
| Short Label | hCDK18 |
| Category | organism-gene |
DAG ViewQ07002 (CDK18) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S14 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648 | ||
| S16 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S74 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19369195 | ||
| S89 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 18669648, 24275569, ... | ||
| S94 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K95 | Acetylation | score1 | PhosphoSitePlus | |||
| S98 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| K112 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S117 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19369195 | ||
| K122 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S125 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S132 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 21406692 | ||
| S134 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T143 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y144 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K146 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K149 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T154 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y155 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T157 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K164 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K173 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K267 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K290 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K445 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K451 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R465 | Methylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S14 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
| S62 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S74 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S89 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
| S98 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S117 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S132 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 | ||
| S134 | Phosphorylation | score0 | HPRD | 18669648, 17924679 | ||
| Y155 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T157 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S472 | Phosphorylation | score0 | HPRD | 18691976 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S14 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
| S62 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S74 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S89 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S95 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K125 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S128 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S147 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S162 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18691976, 18669648, 20068231 | ||
| S164 | Phosphorylation | score0 | HPRD | 18669648, 17924679 | ||
| Y185 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T187 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S502 | Phosphorylation | score0 | HPRD | 18691976 |
Q07002 (CDK18) as PTM Enzyme
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S14 | F14 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S94 | G94 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
| S117 | N117 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S132 | F132 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S134 | L134 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S147 | N147 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc, cosmic, icgc ] | |
| K149 | R149 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S162 | F162 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S164 | L164 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
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