iPTMnet Report for Q06945 (SOX4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06945 / SOX4_HUMAN
Protein Name Transcription factor SOX-4
Gene Name Name: SOX4
Organism Homo sapiens (Human)

PRO ID PR:Q06945
DAG View
PRO Name transcription factor SOX-4 (human)
Definition A transcription factor SOX-4 that is encoded in the genome of human.
Short Label hSOX4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06945 (SOX4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
R75 Methylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K95 Acetylation PhosphoSitePlus   UniProt 26291311
K101 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
S161 Phosphorylation HPRD   PhosphoSitePlus 18452278
S174 Phosphorylation PhosphoSitePlus
S175 Phosphorylation HPRD   PhosphoSitePlus 18452278
S185 Phosphorylation HPRD   PhosphoSitePlus 18452278
S191 Phosphorylation PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
S307 Phosphorylation HPRD 15345747
S347 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T54 P54 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K91 E91 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K118 E118 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S148 C148 Biomuta DOID:1324 / lung cancer [ cosmic ]
S174 I174 Biomuta DOID:1324 / lung cancer [ cosmic ]
K192 E192 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S348 P348 Biomuta DOID:10534 / stomach cancer [ icgc ]