iPTMnet Report for Q06830 (PRDX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06830 / PRDX1_HUMAN
Protein Name Peroxiredoxin-1
Gene Name Name: PRDX1
Synonyms:PAGA,PAGB,TDPX2;
Organism Homo sapiens (Human)

PRO ID PR:Q06830
DAG View
PRO Name peroxiredoxin-1 (human)
Definition A peroxiredoxin-1 that is encoded in the genome of human.
Short Label hPRDX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06830 (PRDX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 25944712
K7 Acetylation IEDB   PhosphoSitePlus   UniProt 34357683, 19608861
K7 Sumoylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
K16 Acetylation PhosphoSitePlus   UniProt 19608861
K16 Methylation PhosphoSitePlus
K16 Sumoylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
T18 Phosphorylation Q13043 (STK4) PhosphoSitePlus 23386615
K27 Acetylation PhosphoSitePlus   UniProt 19608861
K27 Methylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S32 Phosphorylation Q96KB5 (PBK) PhosphoSitePlus   RLIMS-P   Signor   UniProt 20647304, 23186163, 24275569
Y34 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus   UniProt 19608861
K35 Ubiquitination PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
C52 S-Nitrosylation dbSNO 12033427, 14559909, 23796488, ...15683743, 17519234
K67 Acetylation PhosphoSitePlus
K67 Sumoylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
C83 Methylation IEDB 31844290
T90 Phosphorylation P24941 (CDK2) , Q00534 (CDK6) , P06493 (CDK1) , P11802 (CDK4) , Q13043 (STK4) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15890005, 11986303, 26150388, ...23386615
K92 Acetylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K93 Sumoylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K136 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
R151 Methylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
R158 Methylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
C173 Methylation IEDB 31844290
C173 S-Nitrosylation dbSNO 19366988, 14559909, 2212679, ...23796488, 17519234, 18335467, 20140087, 22126794, 26338901, 12033427, 15683743
K178 Acetylation PhosphoSitePlus
K178 Methylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S181 O-Glycosylation GlyGen 16408927, 33214551, 35138101, ...30397120, 26374642, 34725712, 34019948, 35008409, 35132862, 35083852, 32119511, 20305658, 18984734
S181 Phosphorylation PhosphoSitePlus
T183 Phosphorylation Q13043 (STK4) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 17287340, 23386615
K185 Acetylation PhosphoSitePlus
K185 Sumoylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
K192 Methylation PhosphoSitePlus
K192 Sumoylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
Y194 Phosphorylation P06239 (LCK) HPRD   phospho.ELM   PhosphoSitePlus 15592455, 20178744
S196 Phosphorylation PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y34 N34 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C52 S52 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S80 P80 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
K92 N92 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S106 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S126 L126 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R151 H151 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R151 C151 Biomuta DOID:1324 / lung cancer [ cosmic ]
R151 S151 Biomuta DOID:3571 / liver cancer [ cosmic ]
K185 N185 Biomuta DOID:1793 / pancreatic cancer [ icgc ]