Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06787 / FMR1_HUMAN
Protein Name Synaptic functional regulator FMR1
Gene Name Name: FMR1
Organism Homo sapiens (Human)

PRO ID PR:Q06787
DAG View
PRO Name synaptic functional regulator FMR1 (human)
Definition A synaptic functional regulator FMR1 that is encoded in the genome of human.
Short Label hFMR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06787 (FMR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S11 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus   UniProt 20068231
K372 Ubiquitination PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
R471 Methylation PhosphoSitePlus
R474 Methylation PhosphoSitePlus
R477 Methylation PhosphoSitePlus
S497 Phosphorylation RLIMS-P 24658146
S500 Phosphorylation P23443 (RPS6KB1) , P68400 (CSNK2A1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 22080836, 24658146, 12446764, ...24806451, 18474609, 24275569, 31112584
T502 Phosphorylation RLIMS-P 24658146
S504 Phosphorylation RLIMS-P 24658146
S511 Phosphorylation PhosphoSitePlus
R534 Methylation PhosphoSitePlus
R539 Methylation PhosphoSitePlus
R544 Methylation PhosphoSitePlus   UniProt 16922515
R546 Methylation PhosphoSitePlus
T598 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S370 Phosphorylation HPRD 20068231
Y488 Phosphorylation HPRD 17081983
T489 Phosphorylation HPRD 17081983
S490 Phosphorylation HPRD 17081983
S504 Phosphorylation HPRD 17081983
S511 Phosphorylation HPRD 17081983, 18452278
S514 Phosphorylation HPRD 17081983
T518 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S370 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S577 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S370 Phosphorylation PhosphoSitePlus
R463 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K302 N302 Biomuta DOID:3571 / liver cancer [ icgc ]
S370 I370 Biomuta DOID:1324 / lung cancer [ cosmic ]
R471 Q471 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:1324 / lung cancer [ tcga ]
R471 * Biomuta DOID:363 / uterine cancer [ tcga ]
R474 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S497 * Biomuta DOID:1324 / lung cancer [ tcga ]
S500 Y500 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S500 F500 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S514 P514 Biomuta DOID:3070 / malignant glioma [ tcga ]
S514 L514 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
R534 C534 Biomuta DOID:363 / uterine cancer [ tcga ]