iPTMnet Report Q06609 RAD51

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q06609 / RAD51_HUMAN
Protein Name	DNA repair protein RAD51 homolog 1
Gene Name	Name: RAD51 Synonyms:RAD51A,RECA;
Organism	Homo sapiens (Human)

PRO ID	PR:Q06609 DAG View
PRO Name	DNA repair protein RAD51 homolog 1 (human)
Definition	A DNA repair protein RAD51 homolog 1 that is encoded in the genome of human.
Short Label	hRAD51
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q06609 (RAD51) as Substrate

Expanded View

Search:

	Site Select all By amino acid All Serine All Threonine All Tyrosine By position A2 T13 S14 Y54 K57 K58 K64 K70 K73 K107 K156 Y301 T309 C312 Y315 K338	PTM Type Select all Acetylation Methylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 3 4	Source Select all IEDB PRO PhosphoSitePlus RLIMS-P RLIMS-P+ Signor UniProt neXtProt phospho.ELM	PMID
	A2	Acetylation		score1	UniProt	22814378
	T13	Phosphorylation	P68400 (CSNK2A1)	score4	PhosphoSitePlus RLIMS-P	22325354, 24835992, 26811421
	S14	Phosphorylation	P53350 (PLK1)	score4	neXtProt PhosphoSitePlus RLIMS-P	22325354, 24835992, 26811421
	Y54	Phosphorylation	A0A173G4P4 (Abl fusion) , P00519 (ABL1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P+ RLIMS-P Signor UniProt	9461559, 19427856, 28571978
	K57	Sumoylation		score1	PhosphoSitePlus
	K58	Ubiquitination		score3	PhosphoSitePlus UniProt	23393192
	K64	Ubiquitination		score3	PhosphoSitePlus UniProt	23393192
	K70	Sumoylation		score1	PhosphoSitePlus
	K73	Ubiquitination		score1	PhosphoSitePlus
	K107	Ubiquitination		score1	PhosphoSitePlus
	K156	Acetylation		score1	PhosphoSitePlus
	K156	Ubiquitination		score1	PhosphoSitePlus
	Y301	Phosphorylation		score1	PhosphoSitePlus
	T309	Phosphorylation	O14757 (CHEK1)	score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	24204313, 15665856, 31847370, ...27685627
	C312	Methylation		score1	IEDB	31844290
	Y315	Phosphorylation	A9UF07 (BCR/ABL fusion) , P00519 (ABL1) , A0A173G4P4 (Abl fusion)	score4	phospho.ELM PhosphoSitePlus RLIMS-P+ RLIMS-P Signor	19285032, 15165851, 24023853, ...15330855, 27685627, 28571978, 11684015, 10212258, 19427856
	K338	Acetylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Threonine All Tyrosine By position Y54 T309 Y315	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all HPRD	PMID
	Y54	Phosphorylation	P00519 (ABL1)	score1	HPRD	9461559
	T309	Phosphorylation	O14757 (CHEK1)	score1	HPRD	15665856
	Y315	Phosphorylation	P00519 (ABL1)	score1	HPRD	10212258

Search:

	Site Select all By amino acid All Tyrosine By position Y54	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all HPRD	PMID
	Y54	Phosphorylation	P00519 (ABL1)	score1	HPRD	9461559

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000048994 (hRAD51/Phos:2)	Sites Select all pT309	PTM Enzyme	Source Select all PRO	PMID
	PR:000048994 (hRAD51/Phos:2)	pT309		PRO

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P51587 (BRCA2)	Site Select all By amino acid All Serine By position S3291	Interactant Select all Q06609 (RAD51)	Association type Select all unknown	Source Select all eFIP	PMID
	Phosphorylation	P51587 (BRCA2)	S3291	Q06609 (RAD51)	unknown	eFIP	32785644

Proteoform PPIs

Search:

	Protein 1 Select all PR:000045544 (hBRCA2/Phos:2) PR:Q96B01-2 (hRAD51AP1/iso:2) PR:Q96B01-3 (hRAD51AP1/iso:3)	Relation Select all Interaction decreased Interaction	Protein 2 Select all PR:Q06609 (hRAD51)	Source Select all PRO	PMID
	PR:000045544 (hBRCA2/Phos:2)	decreased Interaction	PR:Q06609 (hRAD51)	PRO	18317453
	PR:Q96B01-2 (hRAD51AP1/iso:2)	Interaction	PR:Q06609 (hRAD51)	PRO	9396801
	PR:Q96B01-3 (hRAD51AP1/iso:3)	Interaction	PR:Q06609 (hRAD51)	PRO	9396801

PTM sites affected in variants

Search:

Site Select all By amino acid By position K57 K70 K73 K107 C312	Variant Select all I70 N107 N57 S312 T73 Y312	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K57	N57	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
K70	I70	Biomuta		DOID:1612 / breast cancer [ cosmic ]
K73	T73	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
K107	N107	Biomuta		DOID:3571 / liver cancer [ cosmic, icgc ]
C312	Y312	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C312	S312	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]