iPTMnet Report for Q06609 (RAD51)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06609 / RAD51_HUMAN
Protein Name DNA repair protein RAD51 homolog 1
Gene Name Name: RAD51
Synonyms:RAD51A,RECA;
Organism Homo sapiens (Human)

PRO ID PR:Q06609
DAG View
PRO Name DNA repair protein RAD51 homolog 1 (human)
Definition A DNA repair protein RAD51 homolog 1 that is encoded in the genome of human.
Short Label hRAD51
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06609 (RAD51) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
T13 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 22325354, 24835992, 26811421
S14 Phosphorylation P53350 (PLK1) neXtProt   PhosphoSitePlus   RLIMS-P 22325354, 24835992, 26811421
Y54 Phosphorylation A0A173G4P4 (Abl fusion) , P00519 (ABL1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 9461559, 19427856, 28571978
K57 Sumoylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus   UniProt 23393192
K64 Ubiquitination PhosphoSitePlus   UniProt 23393192
K70 Sumoylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
T309 Phosphorylation O14757 (CHEK1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24204313, 15665856, 31847370, ...27685627
C312 Methylation IEDB 31844290
Y315 Phosphorylation A9UF07 (BCR/ABL fusion) , P00519 (ABL1) , A0A173G4P4 (Abl fusion) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 19285032, 15165851, 24023853, ...15330855, 27685627, 28571978, 11684015, 10212258, 19427856
K338 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y54 Phosphorylation P00519 (ABL1) HPRD 9461559
T309 Phosphorylation O14757 (CHEK1) HPRD 15665856
Y315 Phosphorylation P00519 (ABL1) HPRD 10212258
Site PTM Type PTM Enzyme Score Source PMID
Y54 Phosphorylation P00519 (ABL1) HPRD 9461559


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048994 (hRAD51/Phos:2) pT309 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P51587 (BRCA2) S3291 Q06609 (RAD51) unknown eFIP 32785644


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000045544 (hBRCA2/Phos:2) decreased Interaction PR:Q06609 (hRAD51) PRO 18317453
PR:Q96B01-2 (hRAD51AP1/iso:2) Interaction PR:Q06609 (hRAD51) PRO 9396801
PR:Q96B01-3 (hRAD51AP1/iso:3) Interaction PR:Q06609 (hRAD51) PRO 9396801


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K57 N57 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K70 I70 Biomuta DOID:1612 / breast cancer [ cosmic ]
K73 T73 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K107 N107 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C312 Y312 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C312 S312 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]