Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06481 / APLP2_HUMAN
Protein Name Amyloid beta precursor like protein 2 precursor
Gene Name Name: APLP2
Synonyms:APPL2;
Organism Homo sapiens (Human)

PRO ID PR:Q06481
DAG View
PRO Name amyloid beta precursor like protein 2 (human)
Definition An amyloid beta precursor like protein 2 that is encoded in the genome of human.
Short Label hAPLP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06481 (APLP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T43 O-Glycosylation GlyGen 30459171, 25813380
K78 Ubiquitination PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
Y233 Phosphorylation PhosphoSitePlus
T303 O-Glycosylation GlyGen 25813380
T303 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
T367 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
T371 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
T380 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S381 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K420 Ubiquitination PhosphoSitePlus
R467 Methylation PhosphoSitePlus
N541 N-Glycosylation GlyGen 23090970, 29741879, 24190977
S590 Phosphorylation UniProt 26091039
S626 O-Glycosylation GlyGen   UniProt 32337544
T658 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T723 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus 9109675
T736 Phosphorylation P53779 (MAPK10) , P45983 (MAPK8) , P06493 (CDK1) , P45984 (MAPK9) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9109675, 14970211
K744 Ubiquitination PhosphoSitePlus
Y750 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T754 Phosphorylation PhosphoSitePlus
Y755 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K756 Ubiquitination PhosphoSitePlus
Y757 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S213 Phosphorylation HPRD 20068231
T303 Phosphorylation HPRD 20068231
T723 Phosphorylation P17252 (PRKCA) HPRD 9109675
T736 Phosphorylation P06493 (CDK1) HPRD 9109675
Y750 Phosphorylation HPRD 18083107, 19901323
Y755 Phosphorylation HPRD 18083107, 18578522


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K78 R78 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S213 L213 Biomuta DOID:4159 / skin cancer [ cosmic ]
K420 T420 Biomuta DOID:3571 / liver cancer [ cosmic ]
R467 C467 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R467 H467 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]