iPTMnet Report for Q06481 (APLP2)
Protein Information
UniProt AC / UniProt ID | Q06481 / APLP2_HUMAN |
Protein Name | Amyloid beta precursor like protein 2 precursor |
Gene Name | Name: APLP2 Synonyms:APPL2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q06481 |
PRO Name | amyloid beta precursor like protein 2 (human) |
Definition | An amyloid beta precursor like protein 2 that is encoded in the genome of human. |
Short Label | hAPLP2 |
Category | organism-gene |
Q06481 (APLP2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T43 | O-Glycosylation | score1 | GlyGen | 30459171, 25813380 | ||
K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
S211 | Phosphorylation | score1 | PhosphoSitePlus | |||
S213 | Phosphorylation | score1 | PhosphoSitePlus | |||
K214 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y233 | Phosphorylation | score1 | PhosphoSitePlus | |||
T303 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
T303 | Phosphorylation | score1 | PhosphoSitePlus | |||
S311 | Phosphorylation | score1 | PhosphoSitePlus | |||
T316 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y327 | Phosphorylation | score1 | PhosphoSitePlus | |||
T367 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 30459171 | ||
T371 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 30459171 | ||
T380 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
S381 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
K420 | Ubiquitination | score1 | PhosphoSitePlus | |||
R467 | Methylation | score1 | PhosphoSitePlus | |||
N541 | N-Glycosylation | score1 | GlyGen | 23090970, 29741879, 24190977 | ||
S590 | Phosphorylation | score1 | UniProt | 26091039 | ||
S626 | O-Glycosylation | score2 | GlyGen UniProt | 32337544 | ||
T658 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
T723 | Phosphorylation | P17252 (PRKCA) | score3 | phospho.ELM PhosphoSitePlus | 9109675 | |
T736 | Phosphorylation | P53779 (MAPK10) , P45983 (MAPK8) , P06493 (CDK1) , P45984 (MAPK9) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 9109675, 14970211 | |
K744 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y750 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
T754 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y755 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
K756 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y757 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S213 | Phosphorylation | score0 | HPRD | 20068231 | ||
T303 | Phosphorylation | score0 | HPRD | 20068231 | ||
T723 | Phosphorylation | P17252 (PRKCA) | score1 | HPRD | 9109675 | |
T736 | Phosphorylation | P06493 (CDK1) | score1 | HPRD | 9109675 | |
Y750 | Phosphorylation | score0 | HPRD | 18083107, 19901323 | ||
Y755 | Phosphorylation | score0 | HPRD | 18083107, 18578522 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K78 | R78 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S213 | L213 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K420 | T420 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
R467 | C467 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
R467 | H467 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] |