iPTMnet Report for Q06481 (APLP2)
Protein Information
| UniProt AC / UniProt ID | Q06481 / APLP2_HUMAN |
| Protein Name | Amyloid beta precursor like protein 2 precursor |
| Gene Name | Name: APLP2 Synonyms:APPL2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q06481 |
| PRO Name | amyloid beta precursor like protein 2 (human) |
| Definition | An amyloid beta precursor like protein 2 that is encoded in the genome of human. |
| Short Label | hAPLP2 |
| Category | organism-gene |
DAG ViewQ06481 (APLP2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T43 | O-Glycosylation | score1 | GlyGen | 30459171, 25813380 | ||
| K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S211 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S213 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K214 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y233 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T303 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| T303 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S311 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T316 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y327 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T367 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 30459171 | ||
| T371 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 30459171 | ||
| T380 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| S381 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| K420 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R467 | Methylation | score1 | PhosphoSitePlus | |||
| N541 | N-Glycosylation | score1 | GlyGen | 23090970, 29741879, 24190977 | ||
| S590 | Phosphorylation | score1 | UniProt | 26091039 | ||
| S626 | O-Glycosylation | score2 | GlyGen UniProt | 32337544 | ||
| T658 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| T723 | Phosphorylation | P17252 (PRKCA) | score3 | phospho.ELM PhosphoSitePlus | 9109675 | |
| T736 | Phosphorylation | P53779 (MAPK10) , P45983 (MAPK8) , P06493 (CDK1) , P45984 (MAPK9) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 9109675, 14970211 | |
| K744 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y750 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| T754 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y755 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| K756 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y757 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S213 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T303 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T723 | Phosphorylation | P17252 (PRKCA) | score1 | HPRD | 9109675 | |
| T736 | Phosphorylation | P06493 (CDK1) | score1 | HPRD | 9109675 | |
| Y750 | Phosphorylation | score0 | HPRD | 18083107, 19901323 | ||
| Y755 | Phosphorylation | score0 | HPRD | 18083107, 18578522 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K78 | R78 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S213 | L213 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K420 | T420 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| R467 | C467 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| R467 | H467 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] |
