iPTMnet Report for Q06265 (EXOSC9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06265 / EXOS9_HUMAN
Protein Name Exosome complex component RRP45
Gene Name Name: EXOSC9
Synonyms:PMSCL1;
Organism Homo sapiens (Human)

PRO ID PR:Q06265
DAG View
PRO Name exosome complex component RRP45 (human)
Definition An exosome complex component RRP45 that is encoded in the genome of human.
Short Label hEXOSC9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06265 (EXOSC9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Ubiquitination PhosphoSitePlus
T4 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus   UniProt 23186163
K67 Ubiquitination PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
C193 Methylation IEDB 31844290
C250 Methylation IEDB 31844290
K252 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K281 Acetylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K297 Acetylation PhosphoSitePlus   UniProt 19608861
K297 Sumoylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
S306 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 19690332, 20068231
V325 Phosphorylation UniProt 24275569
S327 Phosphorylation UniProt 24275569
S346 Phosphorylation PhosphoSitePlus   UniProt 24275569
S353 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S392 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 19217413, 20068231
S392 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 19217413
S394 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 19217413, 20068231
S394 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 19217413
K409 Phosphorylation UniProt 24275569
I411 Phosphorylation UniProt 24275569
T413 Phosphorylation PhosphoSitePlus
K419 Acetylation PhosphoSitePlus
K419 Sumoylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T305 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231
S306 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19007248, 18452278, 19651622, 18669648, 20068231, 19691289
S392 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S394 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
Site PTM Type PTM Enzyme Score Source PMID
T305 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231
S306 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19007248, 18452278, 19651622, 18669648, 20068231, 19691289
S409 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S186 N186 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K252 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K274 N274 Biomuta DOID:363 / uterine cancer [ icgc ]
K300 N300 Biomuta DOID:363 / uterine cancer [ icgc ]
S392 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S392 L392 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S409 L409 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S409 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
I411 T411 Biomuta DOID:10534 / stomach cancer [ cosmic ]