Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06210 / GFPT1_HUMAN
Protein Name Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Gene Name Name: GFPT1
Synonyms:GFAT,GFPT;
Organism Homo sapiens (Human)

PRO ID PR:Q06210
DAG View
PRO Name glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (human)
Definition A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 that is encoded in the genome of human.
Short Label hGFPT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06210 (GFPT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C2 S-Nitrosylation dbSNO 26338901
K25 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus   UniProt 23186163
K114 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
S205 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus 10806197, 9836513
K216 Ubiquitination PhosphoSitePlus
S235 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus 10806197, 9836513
S242 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 19170765
K251 Ubiquitination PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S261 Phosphorylation Q9UQM7 (CAMK2A) , Q13131 (PRKAA1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 16964243, 17941647, ...18669648, 24275569, 19690332, 17081983
T262 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T263 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
C478 S-Nitrosylation dbSNO 26338901
K536 Ubiquitination PhosphoSitePlus
K547 Acetylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
Y553 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K650 Acetylation PhosphoSitePlus
Y684 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T151 Phosphorylation HPRD 20068231
S205 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD   PhosphoSitePlus 10806197
K230 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S235 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD   PhosphoSitePlus 10806197
S239 Phosphorylation PhosphoSitePlus
S243 Phosphorylation Q13131 (PRKAA1) HPRD   PhosphoSitePlus 19413330, 18578522, 18491316, ...16964243, 20230923, 18767875, 20058876, 19664995, 19170765, 17322306, 18669648, 20166139, 19415658, 20068231
T244 Phosphorylation HPRD   PhosphoSitePlus 18578522, 17081983, 20230923, ...19664995, 20166139, 20068231
T245 Phosphorylation HPRD   PhosphoSitePlus 18767875, 19664995, 17322306, ...18669648, 20068231
T376 Phosphorylation HPRD 20068231
T449 Phosphorylation HPRD 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 N48 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K48 R48 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K139 N139 Biomuta DOID:1324 / lung cancer [ tcga ]
K190 R190 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S253 R253 Biomuta DOID:1612 / breast cancer [ tcga ]
T262 K262 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y367 S367 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K375 N375 Biomuta DOID:3571 / liver cancer [ icgc ]
K536 * Biomuta DOID:1909 / melanoma [ tcga ]
Y684 H684 Biomuta DOID:363 / uterine cancer [ tcga ]
K694 T694 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S695 Y695 Biomuta DOID:1793 / pancreatic cancer [ tcga ]