iPTMnet Report for Q06210 (GFPT1)
Protein Information
UniProt AC / UniProt ID | Q06210 / GFPT1_HUMAN |
Protein Name | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
Gene Name | Name: GFPT1 Synonyms:GFAT,GFPT; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q06210 |
PRO Name | glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (human) |
Definition | A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 that is encoded in the genome of human. |
Short Label | hGFPT1 |
Category | organism-gene |
Q06210 (GFPT1) as Substrate
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
C2 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K25 | Ubiquitination | score1 | PhosphoSitePlus | |||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
C55 | Methylation | score1 | IEDB | 31844290 | ||
K56 | Ubiquitination | score1 | PhosphoSitePlus | |||
S103 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K114 | Acetylation | score1 | PhosphoSitePlus | |||
K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
T149 | Phosphorylation | score1 | PhosphoSitePlus | |||
K154 | Ubiquitination | score1 | PhosphoSitePlus | |||
K157 | Ubiquitination | score1 | PhosphoSitePlus | |||
K190 | Ubiquitination | score1 | PhosphoSitePlus | |||
T201 | Phosphorylation | score1 | PhosphoSitePlus | |||
S205 | Phosphorylation | P17612 (PRKACA) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 33897873, 10806197, 9836513 | |
K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
S235 | Phosphorylation | P17612 (PRKACA) | score4 | phospho.ELM PhosphoSitePlus | 10806197, 9836513 | |
S242 | Phosphorylation | Q13131 (PRKAA1) | score3 | PhosphoSitePlus Signor | 19170765 | |
K251 | Ubiquitination | score1 | PhosphoSitePlus | |||
S253 | Phosphorylation | score1 | PhosphoSitePlus | |||
S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
S261 | Phosphorylation | Q9UQM7 (CAMK2A) , Q13131 (PRKAA1) | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 23186163, 16964243, 17941647, ...18669648, 24275569, 19690332, 17081983 | |
T262 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
T263 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y275 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y276 | Phosphorylation | score1 | PhosphoSitePlus | |||
K345 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y367 | Phosphorylation | score1 | PhosphoSitePlus | |||
T368 | Phosphorylation | score1 | PhosphoSitePlus | |||
K375 | Ubiquitination | score1 | PhosphoSitePlus | |||
C392 | Methylation | score1 | IEDB | 31844290 | ||
T467 | Phosphorylation | score1 | PhosphoSitePlus | |||
S470 | Phosphorylation | score1 | PhosphoSitePlus | |||
S473 | Phosphorylation | score1 | PhosphoSitePlus | |||
C478 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K536 | Ubiquitination | score1 | PhosphoSitePlus | |||
K547 | Acetylation | score1 | PhosphoSitePlus | |||
K547 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y553 | Phosphorylation | score1 | PhosphoSitePlus | |||
S557 | Phosphorylation | score1 | PhosphoSitePlus | |||
K640 | Ubiquitination | score1 | PhosphoSitePlus | |||
K650 | Acetylation | score1 | PhosphoSitePlus | |||
Y684 | Phosphorylation | score1 | PhosphoSitePlus | |||
K694 | Ubiquitination | score1 | PhosphoSitePlus | |||
S695 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
T151 | Phosphorylation | score0 | HPRD | 20068231 | ||
S205 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | score3 | HPRD PhosphoSitePlus | 10806197 | |
K230 | Ubiquitination | score1 | PhosphoSitePlus | |||
K233 | Ubiquitination | score1 | PhosphoSitePlus | |||
S235 | Phosphorylation | P17252 (PRKCA) , P17612 (PRKACA) | score3 | HPRD PhosphoSitePlus | 10806197 | |
S239 | Phosphorylation | score1 | PhosphoSitePlus | |||
S243 | Phosphorylation | Q13131 (PRKAA1) | score4 | HPRD PhosphoSitePlus | 19413330, 18578522, 18491316, ...16964243, 20230923, 18767875, 20058876, 19664995, 19170765, 17322306, 18669648, 20166139, 19415658, 20068231 | |
T244 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18578522, 17081983, 20230923, ...19664995, 20166139, 20068231 | ||
T245 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18767875, 19664995, 17322306, ...18669648, 20068231 | ||
T376 | Phosphorylation | score0 | HPRD | 20068231 | ||
T449 | Phosphorylation | score0 | HPRD | 19664995 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K48 | N48 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K48 | R48 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K139 | N139 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
K190 | R190 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
S235 | R235 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
T244 | K244 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S253 | R253 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
T262 | K262 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
Y367 | S367 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
K375 | N375 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K536 | N536 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S557 | P557 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K694 | T694 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S695 | Y695 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] |