iPTMnet Report for Q06203 (PPAT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06203 / PUR1_HUMAN
Protein Name Amidophosphoribosyltransferase precursor
Gene Name Name: PPAT
Synonyms:GPAT;
Organism Homo sapiens (Human)

PRO ID PR:Q06203
DAG View
PRO Name amidophosphoribosyltransferase (human)
Definition An amidophosphoribosyltransferase that is encoded in the genome of human.
Short Label hPPAT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06203 (PPAT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T52 Phosphorylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K62 Methylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
C100 Methylation IEDB 31844290
R130 Methylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
C339 S-Nitrosylation dbSNO 19483679
C348 S-Nitrosylation dbSNO 19483679
K349 Ubiquitination PhosphoSitePlus
T356 Phosphorylation HPRD   PhosphoSitePlus 20068231
K371 Acetylation PhosphoSitePlus
K372 Acetylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K383 Methylation PhosphoSitePlus
T397 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K482 Acetylation PhosphoSitePlus
K499 Acetylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K65 N65 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K65 R65 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y94 H94 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
K220 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K381 E381 Biomuta DOID:9256 / colorectal cancer [ cosmic ]