iPTMnet Report for Q06187 (BTK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06187 / BTK_HUMAN
Protein Name Tyrosine-protein kinase BTK
Gene Name Name: BTK
Synonyms:AGMX1,ATK,BPK;
Organism Homo sapiens (Human)

PRO ID PR:Q06187
DAG View
PRO Name tyrosine-protein kinase BTK (human)
Definition A tyrosine-protein kinase BTK that is encoded in the genome of human.
Short Label hBTK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06187 (BTK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25944712
S21 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 16644721
Y40 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus 23754751
S51 Phosphorylation P31749 (AKT1) PhosphoSitePlus 23754751
S55 Phosphorylation PhosphoSitePlus   UniProt 19369195
S93 Phosphorylation PhosphoSitePlus
S115 Phosphorylation RLIMS-P   UniProt 16644721
C145 Methylation IEDB 31844290
S179 Phosphorylation PhosphoSitePlus
S180 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16564096, 11598012
S180 Phosphorylation P05771 (PRKCB) neXtProt   Signor 11598012
K183 Acetylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
Y223 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 15007095, 32402933, 27282255, ...33981831, 26717038, 25077631, 15939795, 28628824, 29340061, 32503877, 28315597, 8630736, 30416684, 31949019, 31616406, 27602755, 9391111, 30619340, 21752263, 32790160, 12573241, 9188445, 12445832, 32608058, 31457731, 14597636, 28352114, 30108960, 24556163, 25944695, 23186163, 17932028, 28424405, 9326643, 32385234, 30758770, 30341350, 26624983, 9012831, 30026342, 33054082, 14656219, 31862959
Y223 Phosphorylation A0A173G4P4 (Abl fusion) phospho.ELM 12445832
Y223 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 12445832
Y223 Phosphorylation P07948 (LYN) PhosphoSitePlus 9326643
Y223 Phosphorylation P42680 (TEC) PhosphoSitePlus   Signor 12573241
Y223 Phosphorylation Q06187 (BTK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 14597636, 8630736, 12573241, ...24556163
Y223 Phosphorylation Q08881 (ITK) PhosphoSitePlus 12573241
Y225 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
Y344 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus   UniProt 19369195
S366 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
T495 Phosphorylation PhosphoSitePlus 23754751
T495 Phosphorylation P31749 (AKT1) PhosphoSitePlus 23754751
K536 Ubiquitination PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27282255, 9052864, 7565679, ...14597636, 8629002, 27602755, 18083107, 19206206, 11226282, 31949019, 28088788, 35639855, 21752263, 17264076, 9188445, 9012831, 25699547, 28352114, 8630736, 25944695, 28424405, 9326643, 32385234, 30341350, 30026342, 14656219
Y551 Phosphorylation P07948 (LYN) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 8630736, 9326643, 8629002
Y551 Phosphorylation P12931 (SRC) Signor 8629002
Y551 Phosphorylation P43405 (SYK) neXtProt   PhosphoSitePlus   Signor 11226282
Y551 Phosphorylation Q06187 (BTK) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14597636, 8630736, 17264076
T552 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y617 Phosphorylation UniProt 15375214
S623 Phosphorylation UniProt 15375214
S659 Phosphorylation PhosphoSitePlus   UniProt 19369195
Site PTM Type PTM Enzyme Score Source PMID
S180 Phosphorylation HPRD 11598012
S180 Phosphorylation P05771 (PRKCB) HPRD 11598012
Y223 Phosphorylation HPRD 8630736, 8629002, 11598012, ...12573241, 12445832, 16497976
Y223 Phosphorylation P00519 (ABL1) HPRD 8630736, 8629002, 11598012, ...12573241, 12445832, 16497976
Y223 Phosphorylation P42680 (TEC) HPRD 8630736, 8629002, 11598012, ...12573241, 12445832, 16497976
Y223 Phosphorylation Q06187 (BTK) HPRD 8630736, 8629002, 11598012, ...12573241, 12445832, 16497976
Y223 Phosphorylation Q08881 (ITK) HPRD 8630736, 8629002, 11598012, ...12573241, 12445832, 16497976
Y225 Phosphorylation HPRD 16497976
Y361 Phosphorylation HPRD 16497976
Y551 Phosphorylation HPRD   PRO 7565679, 8630736, 11226282, ...8629002, 11598012
Y551 Phosphorylation P07948 (LYN) HPRD 11598012, 8630736, 11226282, ...8629002
Y551 Phosphorylation P43405 (SYK) HPRD 11598012, 8630736, 11226282, ...8629002
Y617 Phosphorylation HPRD 15375214


Q06187 (BTK) as PTM Enzyme



Substrate Site Score Source PMID
P15391-1 (CD19) Y500 HPRD 10201980
P15391-1 (CD19) Y531 HPRD 10933394, 16497976
P16885 (PLCG2) Y753 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15509800, 11606584, 11507089, ...14656219, 10498607
P16885 (PLCG2) Y759 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19901323, 15509800, 7682059, ...11606584, 12181444, 10498607, 14656219, 11507089, 16497976
P16885 (PLCG2) Y1197 HPRD   neXtProt   phospho.ELM   Signor 11507089, 10498607
P16885 (PLCG2) Y1217 HPRD   neXtProt   phospho.ELM   Signor 19901323, 17239630, 16497976, ...11507089, 10498607
P42229 (STAT5A) Y694 HPRD   neXtProt 17016520, 17389395, 11413148, ...7925280, 8617237, 16497976
P42680 (TEC) Y206 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12573241
P42768 (WAS) Y291 HPRD   phospho.ELM   Signor 19901323, 18088087, 12769846, ...10068673, 9742969, 12235133, 16497976
P51813 (BMX) Y216 HPRD   phospho.ELM   PhosphoSitePlus   Signor 12573241
P51813 (BMX) Y224 HPRD   phospho.ELM   Signor 12573241
P58753 (TIRAP) Y86 neXtProt   PhosphoSitePlus   RLIMS-P+ 16439361, 24840642
P58753 (TIRAP) Y106 neXtProt   PhosphoSitePlus   RLIMS-P+ 16439361, 24840642
P58753 (TIRAP) Y187 neXtProt   PhosphoSitePlus 16439361
P78347-2 (GTF2I) Y248 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 9012831, 9837922, 11313464, ...11373296, 11934902
P78347-2 (GTF2I) Y357 HPRD   neXtProt   PhosphoSitePlus 11373296
P78347-4 (GTF2I) Y377 HPRD 11373296
P78347-3 (GTF2I) Y378 HPRD 11373296
P78347-1 (GTF2I) Y398 HPRD   phospho.ELM 11373296
P78347-2 (GTF2I) Y462 HPRD   neXtProt   PhosphoSitePlus 20068231, 11373296
P78347-4 (GTF2I) Y482 HPRD 11373296, 20068231
P78347-3 (GTF2I) Y483 HPRD 11373296, 20068231
P78347-1 (GTF2I) Y503 HPRD   phospho.ELM 11373296, 20068231
Q06187-1 (BTK) Y223 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 14597636, 8630736, 8629002, ...11598012, 24556163, 12573241, 12445832, 16497976
Q06187 (BTK) Y551 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14597636, 8630736, 17264076
Q08881 (ITK) Y180 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12573241
Q13422 (IKZF1) S214 PhosphoSitePlus 23977012
Q13422 (IKZF1) S215 PhosphoSitePlus 23977012
Q9UJV9 (DDX41) Y364 PhosphoSitePlus 25704810
Q9UJV9 (DDX41) Y414 PhosphoSitePlus 25704810
Q9UN19-1 (DAPP1) Y139 HPRD 19901323, 10880360, 17389395


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046518 (hBTK/InitMet-/Phos:2) pY223,pY551 PRO
PR:000046519 (hBTK/InitMet-/Phos:1) pY551 PRO
PR:000045882 (hBTK/Phos:1) pY551 PRO 11226282, 7565679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 G2 Biomuta DOID:4159 / skin cancer [ cosmic ]
S21 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S21 L21 Biomuta DOID:4159 / skin cancer [ cosmic ]
S51 N51 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S55 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S55 A55 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S93 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S93 L93 Biomuta DOID:4159 / skin cancer [ cosmic ]
S115 Y115 Biomuta DOID:4159 / skin cancer [ cosmic ]
C145 S145 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C145 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S180 Y180 Biomuta DOID:1612 / breast cancer [ cosmic ]
S180 F180 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K183 R183 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T191 M191 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ]
K322 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y334 C334 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y345 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y361 N361 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S366 Y366 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S371 F371 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y375 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S553 R553 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y617 C617 Biomuta DOID:363 / uterine cancer [ icgc ]
S623 * Biomuta DOID:1324 / lung cancer [ cosmic ]