iPTMnet Report for Q06124 (PTPN11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06124 / PTN11_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 11
Gene Name Name: PTPN11
Synonyms:PTP2C,SHPTP2;
Organism Homo sapiens (Human)

PRO ID PR:Q06124
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 11 (human)
Definition A tyrosine-protein phosphatase non-receptor type 11 that is encoded in the genome of human.
Short Label hPTPN11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06124 (PTPN11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330
S28 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 23822953, 15592455, ...21442024, 19690332
Y63 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 18827006, 21442024
Y66 Phosphorylation PhosphoSitePlus
T73 Phosphorylation RLIMS-P 25802336
Y80 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K178 Acetylation PhosphoSitePlus
Y179 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   RLIMS-P 25802336
K198 Acetylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus   RLIMS-P 18827006
K280 Acetylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation phospho.ELM   PhosphoSitePlus 12531430
K317 Ubiquitination PhosphoSitePlus
S326 Phosphorylation RLIMS-P 25802336
K389 Ubiquitination PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
Y418 Phosphorylation RLIMS-P 22956765, 22110760
K482 Acetylation PhosphoSitePlus
S502 Phosphorylation RLIMS-P 30375388
Y511 Phosphorylation PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
Y542 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 16414009, 28768764, 17483340, ...35439551, 19187270, 28754897, 22956765, 23822953, 31651330, 32076487, 32586329, 23792876, 16250012, 27121132, 34310951, 19427850, 28208810, 20473329, 12923167, 23420874, 34589963, 18320059, 11684012
T543 Phosphorylation PhosphoSitePlus
Y546 Phosphorylation PRO
Y547 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
T564 Phosphorylation PhosphoSitePlus
T566 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 11781100
S576 Phosphorylation P05771 (PRKCB) Signor 11781100
S576 Phosphorylation P24723 (PRKCH) Signor 11781100
Y580 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23103841, 28208810, 20473329, ...17483340, 20855525, 18827006, 23792876, 32076487, 12923167, 23420874, 28490657, 23186163, 28046066, 19690332
Y584 Phosphorylation PRO
K590 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus   RLIMS-P 11781100
Site PTM Type PTM Enzyme Score Source PMID
T73 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
K594 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y62 Phosphorylation HPRD 17016520, 15951569, 17389395, ...20068231, 16497976
Y63 Phosphorylation HPRD 18083107, 16497976
Y66 Phosphorylation HPRD 16497976
T73 Phosphorylation PhosphoSitePlus 25802336
T73 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 25802336
S189 Phosphorylation PhosphoSitePlus 25802336
S189 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 25802336
Y279 Phosphorylation HPRD 18707149
Y542 Phosphorylation HPRD 8041791
Y542 Phosphorylation P09619 (PDGFRB) HPRD 8041791
S558 Phosphorylation HPRD 19413330
S576 Phosphorylation HPRD 11781100
S576 Phosphorylation P05771 (PRKCB) HPRD 11781100
S576 Phosphorylation P17252 (PRKCA) HPRD 11781100
S576 Phosphorylation P24723 (PRKCH) HPRD 11781100
Y580 Phosphorylation HPRD 17016520, 18578522, 17287340, ...16963136, 18707149, 12522270, 8959326, 16497976
S591 Phosphorylation HPRD 17287340


Q06124 (PTPN11) as PTM Enzyme



Substrate Site Score Source PMID
Q14289-2 (PTK2B) Y864 HPRD 10880513
Q14289-1 (PTK2B) Y906 HPRD 10880513


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048959 (hPTPN11/Phos:1) pY546 PRO
PR:000048960 (hPTPN11/Phos:2) pY546,pY584 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35568 (IRS1) S1223 Q06124 (PTPN11) unknown eFIP 16020478
Phosphorylation Q03135 (CAV1) Y14 Q06124 (PTPN11) unknown eFIP 24632723
Phosphorylation Q03135 (CAV1) Y14 Q06124 (PTPN11) unknown eFIP 25672415
Phosphorylation Q05397 (PTK2) Y397 Q06124 (PTPN11) decreased_association eFIP 18757826
Phosphorylation Q15116 (PDCD1) Y248 Q06124 (PTPN11) unknown eFIP 32184441


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 R28 Biomuta DOID:363 / uterine cancer [ icgc ]
Y62 D62 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y63 C63 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, cosmic ]
T73 A73 Biomuta DOID:1319 / brain cancer [ cosmic ]
T73 I73 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y80 F80 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S142 N142 Biomuta [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S189 A189 Biomuta [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
Y279 C279 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T411 M411 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y418 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S502 P502 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S502 T502 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S502 L502 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
S502 A502 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y542 C542 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y546 C546 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S548 F548 Biomuta DOID:363 / uterine cancer [ cosmic ]
T553 M553 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S554 N554 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S558 I558 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S576 I576 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K590 R590 Biomuta DOID:4159 / skin cancer [ cosmic ]
K594 R594 Biomuta DOID:4159 / skin cancer [ cosmic ]