Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06124 / PTN11_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 11
Gene Name Name: PTPN11
Synonyms:PTP2C,SHPTP2;
Organism Homo sapiens (Human)

PRO ID PR:Q06124
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 11 (human)
Definition A tyrosine-protein phosphatase non-receptor type 11 that is encoded in the genome of human.
Short Label hPTPN11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06124 (PTPN11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330
S28 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 23822953, 15592455, ...21442024, 19690332
Y63 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 18827006, 21442024
Y66 Phosphorylation PhosphoSitePlus
T73 Phosphorylation RLIMS-P 25802336
Y80 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K178 Acetylation PhosphoSitePlus
Y179 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   RLIMS-P 25802336
K198 Acetylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus   RLIMS-P 18827006
K280 Acetylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 8995399, 12531430
K317 Ubiquitination PhosphoSitePlus
S326 Phosphorylation RLIMS-P 25802336
Y327 Phosphorylation RLIMS-P 8995399
K389 Ubiquitination PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
K486 Acetylation PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus
Y519 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
Y546 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus 8041791, 20855525, 12721296, ...11684012, 17483340, 12531430, 16885344
Y546 Phosphorylation P06241 (FYN) PhosphoSitePlus 20855525
Y546 Phosphorylation P08922 (ROS1) neXtProt 16885344
Y546 Phosphorylation P09619 (PDGFRB) neXtProt 8041791
Y546 Phosphorylation Q9UM73 (ALK) PhosphoSitePlus 17483340
T547 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
T568 Phosphorylation PhosphoSitePlus
T570 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus   Signor 11781100
S580 Phosphorylation P05771 (PRKCB) PhosphoSitePlus   Signor 11781100
S580 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 11781100
S580 Phosphorylation P24723 (PRKCH) PhosphoSitePlus   Signor 11781100
Y584 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 17287340, 16094384, 18827006, ...16885344, 11684012, 18083107, 17483340, 8622870, 23186163, 19690332
Y584 Phosphorylation P00519 (ABL1) neXtProt 18827006
Y584 Phosphorylation P08922 (ROS1) neXtProt 16885344
Y584 Phosphorylation P42684 (ABL2) neXtProt 18827006
Y584 Phosphorylation Q9UM73 (ALK) PhosphoSitePlus 17483340
K594 Ubiquitination PhosphoSitePlus
S595 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 11781100, 17287340
S595 Phosphorylation P05771-2 (PRKCB) PhosphoSitePlus   Signor 11781100
S595 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 11781100
S595 Phosphorylation P24723 (PRKCH) PhosphoSitePlus   Signor 11781100
Site PTM Type PTM Enzyme Score Source PMID
Y62 Phosphorylation HPRD 17016520, 15951569, 17389395, ...20068231, 16497976
Y63 Phosphorylation HPRD 18083107, 16497976
Y66 Phosphorylation HPRD 16497976
T73 Phosphorylation PhosphoSitePlus 25802336
T73 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 25802336
S189 Phosphorylation PhosphoSitePlus 25802336
S189 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 25802336
Y279 Phosphorylation HPRD 18707149
Y511 Phosphorylation PhosphoSitePlus
Y542 Phosphorylation HPRD   PhosphoSitePlus 8041791
Y542 Phosphorylation P09619 (PDGFRB) HPRD 8041791
S558 Phosphorylation HPRD 19413330
S576 Phosphorylation HPRD 11781100
S576 Phosphorylation P05771 (PRKCB) HPRD 11781100
S576 Phosphorylation P17252 (PRKCA) HPRD 11781100
S576 Phosphorylation P24723 (PRKCH) HPRD 11781100
Y580 Phosphorylation HPRD   PhosphoSitePlus 17016520, 18578522, 17287340, ...16963136, 18707149, 12522270, 8959326, 16497976
K590 Sumoylation PhosphoSitePlus
S591 Phosphorylation HPRD 17287340


Q06124 (PTPN11) as PTM Enzyme



Substrate Site Score Source PMID
Q14289-2 (PTK2B) Y864 HPRD 10880513
Q14289-1 (PTK2B) Y906 HPRD 10880513


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048959 (hPTPN11/Phos:1) pY546 PRO
PR:000048960 (hPTPN11/Phos:2) pY546,pY584 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35568 (IRS1) S1223 Q06124 (PTPN11) unknown eFIP 16020478
Phosphorylation Q03135 (CAV1) Y14 Q06124 (PTPN11) unknown eFIP 24632723
Phosphorylation Q03135 (CAV1) Y14 Q06124 (PTPN11) unknown eFIP 25672415