iPTMnet Report for Q05823 (RNASEL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05823 / RN5A_HUMAN
Protein Name 2-5A-dependent ribonuclease
Gene Name Name: RNASEL
Synonyms:RNS4;
Organism Homo sapiens (Human)

PRO ID PR:Q05823
DAG View
PRO Name 2-5A-dependent ribonuclease (human)
Definition A 2-5A-dependent ribonuclease that is encoded in the genome of human.
Short Label hRNASEL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05823 (RNASEL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
T607 O-Glycosylation GlyGen 30379171
K609 Ubiquitination PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
K642 Acetylation PhosphoSitePlus
K684 Acetylation PhosphoSitePlus   UniProt 19608861
S738 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 F16 Biomuta DOID:4159 / skin cancer [ cosmic ]
S315 F315 Biomuta DOID:4159 / skin cancer [ cosmic ]
K506 E506 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K506 N506 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
S507 N507 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K627 R627 Biomuta DOID:1324 / lung cancer [ cosmic ]
K642 E642 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]