iPTMnet Report Q05586 GRIN1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q05586 / NMDZ1_HUMAN
Protein Name	Glutamate receptor ionotropic, NMDA 1 precursor
Gene Name	Name: GRIN1 Synonyms:NMDAR1;
Organism	Homo sapiens (Human)

PRO ID	PR:Q05586 DAG View
PRO Name	glutamate receptor ionotropic, NMDA 1 (human)
Definition	A glutamate receptor ionotropic, NMDA 1 that is encoded in the genome of human.
Short Label	hGRIN1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q05586 (GRIN1) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K51	Acetylation		score1	PhosphoSitePlus
	S446	Phosphorylation		score1	PhosphoSitePlus
	T683	Phosphorylation		score1	PhosphoSitePlus
	C744	S-Nitrosylation		score2	dbSNO	12183209, 17196530, 22178444, ...9182795, 17434127
	C798	S-Nitrosylation		score2	dbSNO	12183209, 17196530, 22178444, ...9182795, 17434127
	Y837	Phosphorylation	P12931 (SRC)	score2	PhosphoSitePlus	21113815
	S889	Phosphorylation		score3	phospho.ELM UniProt	8316301
	S890	Phosphorylation	P05129 (PRKCG) , Q9HC98 (NEK6)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	15936117, 12023960, 8316301, ...17950559
	S896	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	20623543, 19476542, 15936117, ...22114277, 16363995, 8316301
	S897	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	17950559, 26038702, 12824058, ...14973229, 22114277, 19476542, 8316301
	T900	Phosphorylation		score1	PhosphoSitePlus
	S901	Phosphorylation		score1	PhosphoSitePlus
	T902	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T683	Phosphorylation		score0	HPRD	18452278
	T879	Phosphorylation		score1	HPRD	10049997
	S889	Phosphorylation		score1	HPRD	8316301
	S890	Phosphorylation		score2	HPRD	9030583, 10049997, 8316301
	S896	Phosphorylation		score2	HPRD	9030583, 10049997, 8316301
	S897	Phosphorylation		score2	HPRD	9030583, 14973229, 8316301

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T683	Phosphorylation		score0	HPRD	18452278

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T683	Phosphorylation		score0	HPRD	18452278

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y196	Phosphorylation		score1	PhosphoSitePlus
	S203	Phosphorylation		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S446	I446	Biomuta		DOID:3571 / liver cancer [ icgc ]
C798	Y798	Biomuta		DOID:1324 / lung cancer [ tcga ]
T900	M900	Biomuta		DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ cosmic, tcga ] DOID:0070003 / blastoma [ cosmic ]