iPTMnet Report for Q05586 (GRIN1)
Protein Information
UniProt AC / UniProt ID | Q05586 / NMDZ1_HUMAN |
Protein Name | Glutamate receptor ionotropic, NMDA 1 precursor |
Gene Name | Name: GRIN1 Synonyms:NMDAR1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q05586 |
PRO Name | glutamate receptor ionotropic, NMDA 1 (human) |
Definition | A glutamate receptor ionotropic, NMDA 1 that is encoded in the genome of human. |
Short Label | hGRIN1 |
Category | organism-gene |
Q05586 (GRIN1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K51 | Acetylation | score1 | PhosphoSitePlus | |||
T205 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
S446 | Phosphorylation | score1 | PhosphoSitePlus | |||
T683 | Phosphorylation | score1 | PhosphoSitePlus | |||
C744 | S-Nitrosylation | score2 | dbSNO | 12183209, 17196530, 22178444, ... | ||
C798 | S-Nitrosylation | score2 | dbSNO | 12183209, 17196530, 22178444, ... | ||
Y837 | Phosphorylation | P12931 (SRC) | score2 | PhosphoSitePlus | 21113815 | |
S889 | Phosphorylation | score3 | phospho.ELM UniProt | 8316301 | ||
S890 | Phosphorylation | P05129 (PRKCG) , Q9HC98 (NEK6) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 17950559, 12023960, 15936117, ... | |
S896 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 20623543, 19476542, 12824058, ... | ||
S897 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 17950559, 15485490, 26038702, ... | ||
T900 | Phosphorylation | score1 | PhosphoSitePlus | |||
S901 | Phosphorylation | score1 | PhosphoSitePlus | |||
T902 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T683 | Phosphorylation | score0 | HPRD | 18452278 | ||
T879 | Phosphorylation | score1 | HPRD | 10049997 | ||
S889 | Phosphorylation | score1 | HPRD | 8316301 | ||
S890 | Phosphorylation | score2 | HPRD | 9030583, 10049997, 8316301 | ||
S896 | Phosphorylation | score2 | HPRD | 9030583, 10049997, 8316301 | ||
S897 | Phosphorylation | score2 | HPRD | 9030583, 14973229, 8316301 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y196 | Phosphorylation | score1 | PhosphoSitePlus | |||
S203 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T205 | K205 | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc ] | |
S446 | I446 | Biomuta | DOID:3571 / liver cancer [ icgc ] | |
C798 | Y798 | Biomuta | DOID:1324 / lung cancer [ tcga ] | |
T900 | M900 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ cosmic, tcga ] DOID:0070003 / blastoma [ cosmic ] |