iPTMnet Report for Q05586 (GRIN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05586 / NMDZ1_HUMAN
Protein Name Glutamate receptor ionotropic, NMDA 1 precursor
Gene Name Name: GRIN1
Synonyms:NMDAR1;
Organism Homo sapiens (Human)

PRO ID PR:Q05586
DAG View
PRO Name glutamate receptor ionotropic, NMDA 1 (human)
Definition A glutamate receptor ionotropic, NMDA 1 that is encoded in the genome of human.
Short Label hGRIN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05586 (GRIN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K51 Acetylation PhosphoSitePlus
T205 O-Glycosylation GlyGen 31492838, 28657654
N368 N-Glycosylation GlyGen 22875940
S446 Phosphorylation PhosphoSitePlus
T683 Phosphorylation PhosphoSitePlus
C744 S-Nitrosylation dbSNO 12183209, 17196530, 22178444, ...9182795, 17434127
C798 S-Nitrosylation dbSNO 12183209, 17196530, 22178444, ...9182795, 17434127
Y837 Phosphorylation P12931 (SRC) PhosphoSitePlus 21113815
S867 O-Glycosylation GlyGen 31492838, 28657654
S889 Phosphorylation phospho.ELM   UniProt 8316301
S890 Phosphorylation P05129 (PRKCG) , Q9HC98 (NEK6) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 12023960, 15936117, 8316301
S896 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 20623543, 19476542, 12824058, ...30900515, 16363995, 8316301
S897 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26377910, 15485490, 26038702, ...12824058, 14973229, 19476542, 8316301
T900 Phosphorylation PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
T902 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T683 Phosphorylation HPRD 18452278
T879 Phosphorylation HPRD 10049997
S889 Phosphorylation HPRD 8316301
S890 Phosphorylation HPRD 9030583, 10049997, 8316301
S896 Phosphorylation HPRD 9030583, 10049997, 8316301
S897 Phosphorylation HPRD 9030583, 14973229, 8316301
Site PTM Type PTM Enzyme Score Source PMID
T683 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
T683 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
Y196 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y196 H196 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S203 P203 Biomuta DOID:1319 / brain cancer [ cosmic ]
T205 K205 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S446 C446 Biomuta DOID:4159 / skin cancer [ cosmic ]
C798 Y798 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S867 C867 Biomuta DOID:4159 / skin cancer [ cosmic ]
T900 M900 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]