Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05513 / KPCZ_HUMAN
Protein Name Protein kinase C zeta type
Gene Name Name: PRKCZ
Synonyms:PKC2;
Organism Homo sapiens (Human)

PRO ID PR:Q05513
DAG View
PRO Name protein kinase C zeta type (human)
Definition A protein kinase C zeta type that is encoded in the genome of human.
Short Label hPRKCZ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05513 (PRKCZ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y143 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
S223 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S228 Phosphorylation PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
T410 Phosphorylation O15530 (PDPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11141077, 20844151, 16829026, ...16820280, 9748166, 11222751, 14580237, 15314172, 16051884, 9768361, 12781924, 17335005, 12887331, 10075713, 20332120
T414 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
T560 Phosphorylation Q05513 (PRKCZ) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11141077, 9748166, 28285879, ...14580237, 33301813, 16051884, 18669648, 24275569, 15665819
Site PTM Type PTM Enzyme Score Source PMID
S223 Phosphorylation HPRD 17081983
T410 Phosphorylation O15530 (PDPK1) HPRD 10357815, 11222751, 14500673, ...9748166, 18691976
T560 Phosphorylation Q05513 (PRKCZ) HPRD 18669648, 9748166
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 17081983
T227 Phosphorylation O15530 (PDPK1) HPRD 10357815, 11222751, 14500673, ...9748166, 18691976
T377 Phosphorylation Q05513 (PRKCZ) HPRD 18669648, 9748166


Q05513 (PRKCZ) as PTM Enzyme



Substrate Site Score Source PMID
O14920-1 (IKBKB) S177 HPRD   neXtProt   PhosphoSitePlus   Signor 10195894, 10022904, 9689078, ...10779355
O14920 (IKBKB) S181 HPRD   neXtProt   PhosphoSitePlus   Signor 10195894, 9689078, 10022904, ...10779355
O14965 (AURKA) T287 neXtProt 19668197
O43175 (PHGDH) S55 PhosphoSitePlus 23374352
O43175 (PHGDH) T57 PhosphoSitePlus 23374352
O43175 (PHGDH) T78 PhosphoSitePlus 23374352
O43315 (AQP9) S11 neXtProt   PhosphoSitePlus   Signor 17346701, 21873454
O43315 (AQP9) S222 PhosphoSitePlus 17346701
P05023 (ATP1A1) S16 neXtProt   Signor 12671055
P08047 (SP1) S641 neXtProt   PhosphoSitePlus   Signor 16943418, 19464346, 18258854
P08047 (SP1) T668 neXtProt   PhosphoSitePlus   Signor 16943418, 18258854
P08047 (SP1) S670 neXtProt   PhosphoSitePlus   Signor 16943418, 18258854
P08047 (SP1) T681 neXtProt   PhosphoSitePlus   Signor 16943418, 18258854
P10636-8 (MAPT) S258 PhosphoSitePlus 11104762
P10636-8 (MAPT) S293 PhosphoSitePlus 11104762
P10636-8 (MAPT) S324 PhosphoSitePlus 11104762
P10636-8 (MAPT) S352 PhosphoSitePlus 11104762
P14598 (NCF1) S303 Signor 12056906
P14598 (NCF1) S304 PhosphoSitePlus   Signor 20920494, 12056906
P14598 (NCF1) S315 Signor 12056906
P14598 (NCF1) S320 Signor 12056906
P14598 (NCF1) S328 Signor 12056906
P14598 (NCF1) S359 Signor 12056906
P14598 (NCF1) S370 Signor 12056906
P14598 (NCF1) S379 Signor 12056906
P17252 (PRKCA) S657 HPRD 18691976, 12162751, 8856079, ...10339425, 20068231
P27448 (MARK3) T564 neXtProt   PhosphoSitePlus   Signor 15084291
P28329-3 (CHAT) S440 HPRD   PhosphoSitePlus 15381704
P28329-3 (CHAT) S476 HPRD   PhosphoSitePlus 15381704
P28329-1 (CHAT) S558 HPRD   Signor 15381704
P28329-1 (CHAT) S594 HPRD   Signor 15381704
P29474 (NOS3) T495 Signor 24379783
P30086 (PEBP1) S153 HPRD 14654844, 20166139, 12551925, ...20068231
P31749 (AKT1) T34 neXtProt 14560023
P31946-1 (YWHAB) S132 HPRD 10620507
P31946-1 (YWHAB) T143 HPRD 10620507
P35222 (CTNNB1) S45 PhosphoSitePlus 25660024
P35568 (IRS1) S323 neXtProt   PhosphoSitePlus   Signor 16129678, 16611834, 15069075
P35568 (IRS1) S441 PhosphoSitePlus 16611834
P35568 (IRS1) S1101 Signor 17360977
P35580 (MYH10) S1937 neXtProt   PhosphoSitePlus   Signor 16611744
P35611 (ADD1) S726 PhosphoSitePlus   Signor 15611095, 8810272, 9679146
P35612 (ADD2) S713 PhosphoSitePlus   Signor 15611095, 16116087
P41594-2 (GRM5) S840 HPRD 15894802
P46937 (YAP1) S109 PhosphoSitePlus 25660024
P46937 (YAP1) T110 PhosphoSitePlus 25660024
P49757-2 (NUMB) S7 HPRD 17203073
P49757-2 (NUMB) S295 HPRD 18767875, 17203073
P49768 (PSEN1) S346 HPRD   Signor 14576165
P49841 (GSK3B) S9 PhosphoSitePlus   RLIMS-P+   Signor 26711256, 14657655, 18353303
P49841 (GSK3B) S147 PhosphoSitePlus 26711256
P55040 (GEM) S261 PhosphoSitePlus 14701738
P55211-1 (CASP9) S144 HPRD   neXtProt   PhosphoSitePlus   Signor 16287866
P60484 (PTEN) S380 PhosphoSitePlus 18321849
P60484 (PTEN) T382 PhosphoSitePlus 18321849
P60484 (PTEN) T383 PhosphoSitePlus 18321849
P61587 (RND3) S210 PhosphoSitePlus 23622247
Q04206-1 (RELA) S311 HPRD   neXtProt   PhosphoSitePlus   Signor 12881425, 15210811, 21131967, ...17183360
Q05513-2 (PRKCZ) T377 HPRD 18669648, 9748166
Q05513 (PRKCZ) T560 HPRD   RLIMS-P+   Signor 11141077, 18669648, 9748166, ...15665819
Q05655-1 (PRKCD) S664 HPRD 18691976, 20058876, 15302935, ...11381116, 18452278, 18669648, 20068231
Q07812 (BAX) S184 neXtProt   PhosphoSitePlus   Signor 17525161
Q12933 (TRAF2) S55 PhosphoSitePlus   Signor 19336568
Q13164 (MAPK7) S486 neXtProt 20538799
Q13469 (NFATC2) S53 neXtProt 12021260, 17398070
Q13469 (NFATC2) S56 neXtProt 12021260, 17398070
Q15139 (PRKD1) S738 neXtProt 12407104
Q15139 (PRKD1) S742 neXtProt 12407104
Q15466 (NR0B2) T55 PhosphoSitePlus 23824184
Q15831 (STK11) S307 PhosphoSitePlus   Signor 19414597
Q15831-2 (STK11) S399 PhosphoSitePlus 23612973
Q15831 (STK11) S428 neXtProt   PhosphoSitePlus   Signor 16407220, 18321849, 18250273, ...19414597
Q16612 (NREP) S59 PhosphoSitePlus 16229809
Q16625 (OCLN) T403 PhosphoSitePlus 21545357
Q16625 (OCLN) T404 PhosphoSitePlus 21545357
Q16625 (OCLN) T424 PhosphoSitePlus 21545357
Q16625 (OCLN) T438 PhosphoSitePlus 21545357
Q5JVS0 (HABP4) T354 HPRD   PhosphoSitePlus   Signor 14699138
Q5JVS0-1 (HABP4) T375 HPRD   PhosphoSitePlus   Signor 14699138
Q6STE5 (SMARCD3) S247 PhosphoSitePlus 23219531
Q7KZI7 (MARK2) T596 neXtProt   PhosphoSitePlus   Signor 15084291, 15324659
Q8IX03 (WWC1) S975 HPRD   neXtProt   PhosphoSitePlus 15081397
Q8IX03-1 (WWC1) S978 HPRD   neXtProt   PhosphoSitePlus 15081397
Q8TEW0 (PARD3) S827 Signor 12390250
Q96A00 (PPP1R14A) T38 HPRD   PhosphoSitePlus   Signor 15003508, 32471307
Q96RI1-2 (NR1H4) T442 PhosphoSitePlus 18668687
Q96RI1 (NR1H4) T456 Signor 18668687
Q9UBS0 (RPS6KB2) S473 PhosphoSitePlus 12529391
Q9Y243-1 (AKT3) T305 HPRD   Signor 12162751, 9512493
Q9Y243 (AKT3) S472 neXtProt 12162751
Q9Y6Q9 (NCOA3) S1033 PhosphoSitePlus 18313384
Q9Y6Q9 (NCOA3) S1042 PhosphoSitePlus 18313384
Q9Y6Q9 (NCOA3) S1048 PhosphoSitePlus 18313384
Q9Y6Q9 (NCOA3) T1059 PhosphoSitePlus 18313384
Q9Y6Q9 (NCOA3) S1062 PhosphoSitePlus 18313384
Q9Y6Q9 (NCOA3) T1064 PhosphoSitePlus 18313384
Q9Y6Q9 (NCOA3) T1067 PhosphoSitePlus 18313384
Q9Y6Q9 (NCOA3) T1114 PhosphoSitePlus 18313384


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048924 (hPRKCZ/Phos:2) pT410,pT560 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31749 (AKT1) S473 Q05513 (PRKCZ) unknown eFIP 18650932
Phosphorylation P49757 (NUMB) S7 Q05513 (PRKCZ) unknown eFIP 17203073


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S228 L228 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T414 A414 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]