Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05397 / FAK1_HUMAN
Protein Name Focal adhesion kinase 1
Gene Name Name: PTK2
Synonyms:FAK,FAK1;
Organism Homo sapiens (Human)

PRO ID PR:Q05397
DAG View
PRO Name focal adhesion kinase 1 (human)
Definition A focal adhesion kinase 1 that is encoded in the genome of human.
Short Label hPTK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05397 (PTK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 19369195
Y5 Phosphorylation P09619 (PDGFRB) , P08581 (MET) , P00533 (EGFR) neXtProt   PhosphoSitePlus   Signor   UniProt 19369195, 20802513
T13 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S16 Phosphorylation PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus   RLIMS-P 26640543
S29 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
R65 Methylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus   RLIMS-P 17117420
Y155 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation P09619 (PDGFRB) , P12931 (SRC) , P00533 (EGFR) , P51813 (BMX) , P16234 (PDGFRA) , P08581 (MET) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20802513, 16782899, 23716717
K199 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17117420, 12515828
K364 Ubiquitination PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation P12931 (SRC) , Q05397 (PTK2) , P08581 (MET) , P46108 (CRK) , A0A059VC25 (FAK) , P09769 (FGR) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 29422613, 26866924, 11909938, ...10087271, 12147603, 19931412, 12370243, 12876384, 17395594, 19923420, 19260479, 22824793, 26542021, 22174684, 24123071, 29791208, 23339185, 22544741, 23102268, 29066806, 24655477, 8941336, 25193862, 28134933, 19294408, 23357870, 7509446, 20224789, 28225063, 29186907, 23858760, 27460083, 26388843, 24706070, 29276408, 22710722, 27278471, 18171471, 22734001, 18562041, 26961176, 16415178, 16574795, 14712221, 27428469, 30728047, 30488595, 17215324, 29190494, 19568240, 27487141, 18923058, 28611383, 28423580, 28068967, 21418517, 10085298, 17524523, 28642549, 26993780, 28338656, 30696915, 21716326, 28076322, 28188308, 24858039, 26919097, 10769034, 29752441, 30539198, 14604860, 23272972, 15785954, 19740433, 20180147, 27402964, 27467982, 30498362, 25958313, 25277206, 23755096, 17117420, 28459432, 25113248, 10794722, 25300309, 11585739, 20160475, 19339212, 11807823, 29021002, 23485561, 30033448, 30744493, 12640026, 17431114, 26752742, 29700289, 22216254, 12215217, 12391143, 29439667, 17234784, 24885534, 18382658, 18198129, 24040310, 29046395, 18805444, 11448998, 19369195, 11438458, 21359179, 21660950, 26689988, 19834610, 19553453, 29491429, 26172215, 20802513, 20354780, 17192257, 31383893, 20122724, 27248472, 11602246, 23970932, 28124908, 18989950, 17219439, 26649283, 29434841, 24294595, 19787193, 22070920, 25708150, 25778692, 30555628, 22136719, 18032789, 28542214, 30464516, 21556755, 30571746, 24062525, 30087707, 11857088, 17234774, 14610060, 23812425, 25753414, 29484384, 11313859, 15735019, 25617898, 20847951, 26501082, 21084641, 24039840, 24039841, 25193659, 15707596, 12876277, 28688145, 11891289, 15210734, 11027591, 15598735, 19657053, 20018849, 10958798, 18083107, 31186741, 20357007, 18314876, 9148935, 15096502, 22267972, 11314030, 24010829, 30816469, 27246739, 16267008, 28741790, 28416479, 21209368, 31160603, 26517238, 27237320, 30779783, 25705585, 30065198, 26119934, 15138291, 19695571, 20724588, 29263678, 30617204, 29311227, 21344482, 27220365, 29928374, 16917494, 27602495, 18774960, 29151962, 16912186, 24863845, 15331608, 14670178, 20927395, 30531837, 21073482, 18676832, 27790061, 21401419, 25889845, 16782899, 30458784, 27715394, 26821125, 20955590, 24533083, 30836148, 21898412, 24381802, 29593542, 23836527, 24736807, 26294392, 25486573, 24911159, 27286256, 28427224, 29088849, 17589804, 17898132, 20713357, 10047444, 12927054, 29238610, 26833789, 16159962, 15242759, 26365310, 26018803, 25428919, 17828307, 25978354, 26378057, 21426305, 26988603, 18343694, 25539072, 25947155, 26300973, 24201748, 16523241, 20308429, 26456697, 15625302, 11668182, 25313365, 16728403, 26546712, 23128389, 7529876, 21903606, 26004127, 25980494, 22876288, 16998832, 22766511, 29050315, 22069492, 12871985, 20527022, 28415713, 28406574, 29039492, 18922173, 24409152, 26110647, 12960434, 29416084, 29535802, 10856226, 24121667, 30717801, 26984511, 23109808, 12370821, 28424421, 22319618, 25890707, 29728077, 20621036, 29740072, 28715434, 29472531, 12387730, 24586773, 15246682, 23515360, 27611942, 22641287, 10998418, 14703945, 19826415, 25641010, 15263022, 25880415, 19212436, 31060904, 18006843, 23792569, 22938480, 26788094, 24194567, 25187949, 25783411, 25226367, 27793011, 29382358, 17081517, 20657775, 12730223, 26893679, 24772088, 16325748, 20082722, 21720547, 17088251, 8824286, 25351103, 28398603, 15707572, 11494115, 17497960, 16920701, 15561106, 21408150, 10816598, 26975850, 23681745, 25631868, 20378826, 14761895, 22810307, 20021699, 30337877, 16473349, 28445805, 16825486, 30347788, 25056351, 28053698, 26549523, 24885567, 26079101, 28361970, 28450296, 30981841, 24786638, 22550026, 29563383, 29993014, 26546726, 26245992, 11278488, 22194972, 21967109, 16039608, 19029090, 12531888, 19671193, 30563275, 25868388, 27041993, 24681892, 24894151, 12782622, 11696015, 31170089, 30387148, 26703626, 12084011, 26556867, 26848618, 12558988, 23874694, 29915029, 29228673
T406 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation P08581 (MET) , Q05397 (PTK2) , Q14289 (PTK2B) , P12931 (SRC) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21653826, 16760434, 12871985, ...15247219, 16415178, 12960434, 15263022, 12387730, 16254240, 17117420, 11027591, 23272972, 15735019, 15694384, 23970932, 19923420, 7529876, 16782899, 15561106, 24381802
T408 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
Y441 Phosphorylation P51813 (BMX) , P12931 (SRC) PhosphoSitePlus   RLIMS-P 17117420, 23716717
S443 Phosphorylation PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus   RLIMS-P 26365310, 27790061
T503 Phosphorylation PhosphoSitePlus   RLIMS-P 17117420
S517 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 25193862, 18083107, 19369195
S574 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
Y576 Phosphorylation P08581 (MET) , Q05397 (PTK2) , P06241 (FYN) , P07949 (RET) , P09769 (FGR) , A0A059VC25 (FAK) , P51813 (BMX) , P07947 (YES1) , P12931 (SRC) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25193862, 24194567, 17215324, ...19029090, 24885567, 23716717, 17192257, 27495308, 28611383, 26866924, 12387730, 16782899, 19657053, 20018849, 21418517, 11909938, 21454698, 20955590, 27041993, 18171471, 30347788, 17117420, 24675741, 12482769, 18314876, 25753414, 28432466, 14656986, 12876384, 29439667, 24714748, 9038154, 23970932, 24885534, 21716326, 27602495, 21720547, 30066854, 15694384, 28712848, 24736807, 26837847, 21084641, 17088251, 30925742, 16267008, 27286256, 28331230, 28427224, 24162594, 29024195, 17898132, 15707572, 7529876, 29423065, 22938480, 17449913, 22734001, 19212436, 25705585, 29556515, 15735019, 19339212, 22544741, 20927395, 28688145, 24612644, 15561106, 18083107, 29915029, 25778692, 16153436, 29292531, 16293639, 29050315, 30498362, 24681892, 29928374
Y577 Phosphorylation P12931 (SRC) , A0A059VC25 (FAK) , P51813 (BMX) , P07949 (RET) , P08581 (MET) , Q05397 (PTK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25193862, 24885567, 23716717, ...27495308, 16782899, 28611383, 15598735, 12387730, 15735019, 20018849, 28432466, 21454698, 20955590, 27041993, 18171471, 30347788, 19931412, 24681892, 9038154, 17117420, 29439667, 15694384, 23970932, 24885534, 21716326, 30066854, 28712848, 24736807, 29423065, 21720547, 28427224, 24162594, 20378826, 29024195, 7529876, 16523241, 17449913, 19212436, 29556515, 19339212, 11807823, 20927395, 28688145, 24612644, 18083107, 29915029, 25778692, 16153436, 21418517, 29050315, 14712221, 19740433
S580 Phosphorylation PhosphoSitePlus   UniProt 19369195
S677 Phosphorylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
S695 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 23264741
T700 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 23264741
S702 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
Y720 Phosphorylation PhosphoSitePlus
S722 Phosphorylation P49840 (GSK3A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23212450, 16373587, 19339212, ...17192257, 28331230, 15975092, 11160818
S726 Phosphorylation PhosphoSitePlus
S732 Phosphorylation Q13464 (ROCK1) , Q00535 (CDK5) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 14712065, 24121667, 19201755, ...12941275, 23762397, 16760434
Y742 Phosphorylation P12931 (SRC) , P51813 (BMX) PhosphoSitePlus   Signor 17289681, 23716717
Y747 Phosphorylation RLIMS-P 9575224
S759 Phosphorylation PhosphoSitePlus
Y761 Phosphorylation PhosphoSitePlus
T805 Phosphorylation PhosphoSitePlus
S840 Phosphorylation phospho.ELM   PhosphoSitePlus 11160818, 17081983, 17192257
S843 Phosphorylation Q9UQM7 (CAMK2A) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 12927054, 15845548, ...22810307, 17192257, 19923420, 11160818
S850 Phosphorylation PhosphoSitePlus   RLIMS-P 17117420
Y861 Phosphorylation Q13882 (PTK6) , P07949 (RET) , Q05397 (PTK2) , P08581 (MET) , P16591 (FER) , P12931 (SRC) , P07947 (YES1) , P51813 (BMX) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22353809, 29190494, 29870718, ...22356893, 26042227, 19568240, 23716717, 20354780, 21034468, 27694892, 17289681, 18922173, 11927607, 16782899, 30617204, 18343694, 25868388, 20955590, 11696015, 18171471, 15247219, 20657775, 25404487, 12960434, 15673687, 25753414, 12387730, 17117420, 29535802, 11602246, 23970932, 23027128, 16917494, 20847951, 22824793, 15743500, 17219439, 15694384, 18805444, 21036168, 15263022, 26984511, 21682918, 15735019, 12084011, 11313859, 24742605, 22938480, 28154561, 28416479, 17438336, 26848618, 12927054, 19339212, 22544741, 18006843, 11027591, 18083107, 12753909, 16153436, 30981841, 8941336
S887 Phosphorylation PhosphoSitePlus   UniProt 18691976
S892 Phosphorylation phospho.ELM 18669648
S893 Phosphorylation PhosphoSitePlus
Y898 Phosphorylation P51813 (BMX) , P12931 (SRC) PhosphoSitePlus 23716717
S910 Phosphorylation Q00535 (CDK5) , P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 18691976, 23186163, 17692050, ...19369195, 21937583, 29306139, 17192257, 27105500, 19923420, 18669648, 21660950, 20811717, 11160818, 12692126, 20068231
T914 Phosphorylation PhosphoSitePlus   UniProt 20068231
S920 Phosphorylation PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
Y925 Phosphorylation P12931 (SRC) , P09769 (FGR) , P16591 (FER) , P51813 (BMX) , P07947 (YES1) , P07949 (RET) , P08581 (MET) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18032789, 24586773, 19834610, ...21454698, 22641287, 23530035, 29928374, 16917494, 28881794, 27956712, 22824793, 14703945, 19826415, 18805444, 15263022, 24416452, 21359179, 30262433, 22938480, 27926483, 7997267, 24885567, 28755662, 27793011, 23817042, 16782899, 18400991, 18182379, 17478078, 27460083, 9087451, 17219439, 24736807, 27321183, 27286256, 22710722, 24742605, 17438336, 12788385, 16828471, 29748541, 25778692, 25866790, 23958855, 25337707, 25193862, 19568240, 26378057, 26689988, 18343694, 29292531, 30347788, 25056351, 28416479, 21716326, 28076322, 26456697, 30981841, 21084641, 22356893, 14604860, 16153436, 20124721, 29050315, 24409152, 23716717, 19740433, 19657053, 30498362, 10958798, 25868388, 24681892, 12387730, 17117420, 9148935, 28270217, 29662665, 22349353, 20955590, 30717801, 31215502, 20378826, 15817476, 12370821, 26556867, 28424421, 19339212
T929 Phosphorylation PhosphoSitePlus
T963 Phosphorylation PhosphoSitePlus
T967 Phosphorylation PhosphoSitePlus
T971 Phosphorylation PhosphoSitePlus
K1000 Ubiquitination PhosphoSitePlus
Y1007 Phosphorylation P12931 (SRC) , P51813 (BMX) PhosphoSitePlus   RLIMS-P 17117420, 23716717
K1017 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation HPRD 18691976
S16 Phosphorylation HPRD 18691976
T24 Phosphorylation HPRD 18691976
S29 Phosphorylation HPRD 17322306, 18691976
T386 Phosphorylation HPRD 18691976
S390 Phosphorylation Q05397 (PTK2) HPRD 17192257
Y397 Phosphorylation Q05397 (PTK2) , P46108 (CRK) HPRD   PRO 17016520, 7509446, 7529876, ...12370821, 20068231, 11314030
Y407 Phosphorylation Q14289 (PTK2B) , P12931 (SRC) HPRD   PRO 7529876, 16760434
S568 Phosphorylation HPRD 18691976
Y570 Phosphorylation HPRD 18691976
Y576 Phosphorylation P06213 (INSR) , P12931 (SRC) , P07949 (RET) HPRD   PRO 17016520, 17389395, 19664994, ...9507031, 7529876, 20068231
Y577 Phosphorylation P06213 (INSR) , P12931 (SRC) , P07949 (RET) HPRD   PRO 9507031, 7529876, 20068231
S705 Phosphorylation HPRD 18691976
S716 Phosphorylation HPRD 18691976, 20068231
S722 Phosphorylation HPRD 11160818, 18691976, 19664994, ...20068231
S840 Phosphorylation HPRD 11160818, 18691976
S843 Phosphorylation HPRD 11160818, 18691976, 19651622
S850 Phosphorylation Q05397 (PTK2) HPRD 17192257
Y861 Phosphorylation P12931 (SRC) HPRD   PRO 15494733, 8941336, 11602246, ...11927607
S887 Phosphorylation HPRD 18691976
S892 Phosphorylation HPRD 18669648
S910 Phosphorylation HPRD 18691976, 20230923, 20058876, ...18669648, 11160818, 19415658, 20068231
T914 Phosphorylation HPRD 17081983, 20068231
Y925 Phosphorylation Q05397 (PTK2) , P12931 (SRC) HPRD   PRO 7997267, 8816475
Y1016 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
Y688 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y861 Phosphorylation PhosphoSitePlus


Q05397 (PTK2) as PTM Enzyme



Substrate Site Score Source PMID
O00401 (WASL) Y256 neXtProt 14676198
O43707 (ACTN4) Y4 Signor 23454549
O43707 (ACTN4) Y31 Signor 23454549
O43707 (ACTN4) Y265 Signor 23454549
O75962-1 (TRIO) Y2796 HPRD   PhosphoSitePlus 12551902
P07949 (RET) Y905 neXtProt   PhosphoSitePlus   Signor 21454698
P12814 (ACTN1) Y12 HPRD   neXtProt   PhosphoSitePlus   Signor 23454549, 16291744, 11369769
P23634-6 (ATP2B4) Y1176 PhosphoSitePlus 12540962
P26010 (ITGB7) Y753 PhosphoSitePlus 16874740
P26010 (ITGB7) Y758 PhosphoSitePlus 16874740
P29353 (SHC1) Y315 neXtProt 9566877
P49023 (PXN) Y31 HPRD   Signor 15688067, 11337490, 9658172
P49023 (PXN) Y118 HPRD   neXtProt   Signor 17389395, 7537852, 18669648, ...18707149, 7615549, 15688067, 20068231, 9230116
P51813 (BMX) Y40 HPRD 11331870
P56945 (BCAR1) Y410 PhosphoSitePlus 23716717
P56945-1 (BCAR1) Y664 HPRD 9360983, 9360968, 12119061
P56945-1 (BCAR1) Y666 HPRD 9360983
P63000 (RAC1) Y64 PhosphoSitePlus 22163037
Q05397-1 (PTK2) S390 HPRD 17192257
Q05397 (PTK2) Y397 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 17016520, 19369195, 17828307, ...12531888, 20802513, 7509446, 17117420, 10816598, 15598735, 17395594, 11857088, 7529876, 12370821, 27790061, 20068231, 11314030
Q05397 (PTK2) Y407 PhosphoSitePlus   Signor 17117420, 15694384
Q05397 (PTK2) Y576 PhosphoSitePlus   Signor 17117420, 15694384, 11909938, ...7529876
Q05397 (PTK2) Y577 PhosphoSitePlus   Signor 7529876, 15598735, 15694384
Q05397-1 (PTK2) S850 HPRD 17192257
Q05397 (PTK2) Y861 Signor 15694384
Q05397-1 (PTK2) Y925 HPRD 7997267, 8816475
Q14451 (GRB7) Y188 PhosphoSitePlus 19473962
Q14451 (GRB7) Y338 PhosphoSitePlus 19473962
Q658W2 (DKFZp666O0110) S412 HPRD 17192257
Q658W2 (DKFZp666O0110) Y419 HPRD 17016520, 7509446, 7529876, ...12370821, 20068231, 11314030
Q658W2 (DKFZp666O0110) S872 HPRD 17192257
Q658W2 (DKFZp666O0110) Y947 HPRD 7997267, 8816475
Q99961 (SH3GL1) Y315 PhosphoSitePlus   Signor 16054026
Q9H5V8 (CDCP1) Y734 PhosphoSitePlus 14739293
Q9H9S0 (NANOG) Y35 neXtProt   PhosphoSitePlus 22493428
Q9H9S0 (NANOG) Y174 neXtProt   PhosphoSitePlus 22493428
Q9Y2X7 (GIT1) Y321 PhosphoSitePlus 22302306


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048950 (hPTK2/InitMet-/Phos:3) pY397,pY407,pY576,pY577,pS732,pY861,pY925 PRO
PR:000048951 (hPTK2/InitMet-/Phos:4) pY397,pY576,pY577,pY861,pY925 PRO
PR:000048952 (hPTK2/InitMet-/Phos:5) pY397,pY576,pY577,pS732,pY861,pY925 PRO
PR:000026218 (hPTK2/InitMet-/Phos:2) pY397,pY407,pY576,pY577,pY861,pY925 PRO
PR:000026219 (hPTK2/InitMet-/Phos:1) pY397 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49023 (PXN) S178 Q05397 (PTK2) increased_association eFIP 21779367
Phosphorylation P49023 (PXN) S244 Q05397 (PTK2) decreased_association eFIP 18042622
Phosphorylation Q05397 (PTK2) Y397 P20936 (RASA1) decreased_association eFIP 30816469
Phosphorylation Q05397 (PTK2) Y577 P49023 (PXN) inhibited_association eFIP 18171471
Phosphorylation Q05397 (PTK2) Y397 P12931 (SRC) unknown eFIP 27487141
Phosphorylation Q05397 (PTK2) Y397 P12931 (SRC) unknown eFIP 29238610
Phosphorylation Q05397 (PTK2) Y397 P08670 (VIM) unknown eFIP 24858039
Phosphorylation Q05397 (PTK2) Y397 P62993 (GRB2) increased_association eFIP 9148935
Phosphorylation Q05397 (PTK2) Y397 P12931 (SRC) unknown eFIP 26556867
Phosphorylation Q05397 (PTK2) Y397 P12931 (SRC) unknown eFIP 27980455
Phosphorylation Q9Y2X7 (GIT1) Y321 Q05397 (PTK2) unknown eFIP 22302306