iPTMnet Report Q05209 PTPN12

Protein Information

UniProt AC / UniProt ID	Q05209 / PTN12_HUMAN
Protein Name	Tyrosine-protein phosphatase non-receptor type 12
Gene Name	Name: PTPN12
Organism	Homo sapiens (Human)

PRO ID	PR:Q05209 DAG View
PRO Name	tyrosine-protein phosphatase non-receptor type 12 (human)
Definition	A tyrosine-protein phosphatase non-receptor type 12 that is encoded in the genome of human.
Short Label	hPTPN12
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q05209 (PTPN12) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position M1 S19 S39 T40 Y64 S83 Y88 K95 K280 Y301 T318 S323 S324 S332 S342 S369 S397 S398 S402 S412 S435 S449 T454 S466 S468 T490 S491 S494 S499 T501 S507 T509 S514 S517 T519 Y560 T565 S567 T569 S571 T573 T578 T587 S588 T593 S596 S603 S606 S608 S613 T622 S625 T626 T630 S636 S649 S661 S670 S673 T681 S689 T693 S708 S713 S719 Y733 T780	PTM Type Select all Acetylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 4	Source Select all GlyGen IEDB PhosphoSitePlus RLIMS-P Signor UniProt phospho.ELM	PMID
M1	Acetylation		score1	UniProt	22814378, 12665801, 22223895
S19	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	23186163, 32541467, 28842430, ...20068231, 27134172
S39	Phosphorylation	P17612 (PRKACA) , P17252 (PRKCA)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor	7520867, 7909431
T40	Phosphorylation		score1	PhosphoSitePlus
Y64	Phosphorylation		score1	PhosphoSitePlus
S83	Phosphorylation		score1	PhosphoSitePlus
Y88	Phosphorylation		score1	PhosphoSitePlus
K95	Ubiquitination		score1	PhosphoSitePlus
K280	Ubiquitination		score1	PhosphoSitePlus
Y301	Phosphorylation		score1	PhosphoSitePlus
T318	Phosphorylation		score1	PhosphoSitePlus
S323	Phosphorylation		score1	PhosphoSitePlus
S324	Phosphorylation		score1	PhosphoSitePlus
S332	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 17081983, ...18669648, 24275569
S342	Phosphorylation		score1	PhosphoSitePlus
S369	Phosphorylation		score1	PhosphoSitePlus
S397	Phosphorylation		score1	PhosphoSitePlus
S398	Phosphorylation		score1	PhosphoSitePlus
S402	Phosphorylation		score1	PhosphoSitePlus
S412	Phosphorylation		score1	PhosphoSitePlus
S435	Phosphorylation	P17612 (PRKACA) , P17252 (PRKCA)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	7909431, 21406692, 23186163, ...32501498, 18669648, 7520867, 20068231
S449	Phosphorylation		score2	PhosphoSitePlus UniProt	21406692, 23186163, 20068231
T454	Phosphorylation		score1	PhosphoSitePlus
S466	Phosphorylation		score1	PhosphoSitePlus
S468	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
T490	Phosphorylation		score1	PhosphoSitePlus
S491	Phosphorylation		score1	PhosphoSitePlus
S494	Phosphorylation		score1	PhosphoSitePlus
S499	Phosphorylation		score0	RLIMS-P	32501498
T501	O-Glycosylation		score1	GlyGen	32938750
S507	Phosphorylation		score1	PhosphoSitePlus
T509	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S514	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S517	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T519	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	32501498, 18669648
Y560	Phosphorylation		score1	IEDB	32387766
T565	Phosphorylation		score1	PhosphoSitePlus
S567	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
T569	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	32501498, 18669648, 18088087
S571	Phosphorylation	P28482 (MAPK1) , P27361 (MAPK3)	score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	23186163, 18669648, 21876001, ...18088087
T573	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T578	Phosphorylation		score1	PhosphoSitePlus
T587	Phosphorylation		score1	phospho.ELM	18669648
S588	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T593	Phosphorylation		score1	PhosphoSitePlus
S596	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S603	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 18088087, 21406692, ...17081983
S606	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	21406692, 18088087, 17081983, ...18669648, 24275569, 32501498, 23186163
S608	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 17081983
S613	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
T622	O-Glycosylation		score1	GlyGen	23301498, 34019948, 35254053
T622	Phosphorylation		score1	PhosphoSitePlus
S625	O-Glycosylation		score1	GlyGen	23301498, 34019948, 32938750, ...35254053
T626	O-Glycosylation		score1	GlyGen	23301498, 34019948, 35254053
T630	O-Glycosylation		score1	GlyGen	23301498, 34019948, 32938750, ...35254053
S636	Phosphorylation		score1	PhosphoSitePlus
S649	Phosphorylation		score1	PhosphoSitePlus
S661	Phosphorylation		score1	PhosphoSitePlus
S670	Phosphorylation		score1	PhosphoSitePlus
S673	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 18088087, 16964243, ...24275569, 23186163, 20068231
T681	Phosphorylation		score1	PhosphoSitePlus
S689	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 18220336
T693	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 18220336
S708	Phosphorylation		score1	PhosphoSitePlus
S713	Phosphorylation		score1	PhosphoSitePlus
S719	Phosphorylation		score1	PhosphoSitePlus
Y733	Phosphorylation		score1	PhosphoSitePlus
T780	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S19 S39 Y42 S324 S332 S435 S449 T454 S468 T509 S514 S517 T519 S567 T569 S571 T573 T587 S588 T593 S596 T598 S603 S606 S608 S613 S670 S673 S689 T693	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD	PMID
S19	Phosphorylation		score0	HPRD	19651622, 20068231
S39	Phosphorylation	P17612 (PRKACA) , P17252 (PRKCA)	score1	HPRD	7520867
Y42	Phosphorylation		score0	HPRD	20068231
S324	Phosphorylation		score0	HPRD	20058876
S332	Phosphorylation		score0	HPRD	17081983
S435	Phosphorylation	P17252 (PRKCA) , P17612 (PRKACA)	score2	HPRD	19651622, 18767875, 18669648, ...7520867, 20068231
S449	Phosphorylation		score0	HPRD	20068231
T454	Phosphorylation		score0	HPRD	18212344
S468	Phosphorylation		score0	HPRD	18669648
T509	Phosphorylation		score0	HPRD	18669648, 20230923
S514	Phosphorylation		score0	HPRD	18669648
S517	Phosphorylation		score0	HPRD	18669648
T519	Phosphorylation		score0	HPRD	18669648, 16964243
S567	Phosphorylation		score0	HPRD	18669648
T569	Phosphorylation		score0	HPRD	19651622, 18669648, 18088087, ...20068231
S571	Phosphorylation		score0	HPRD	19651622, 18669648, 18088087, ...20068231
T573	Phosphorylation		score0	HPRD	18669648
T587	Phosphorylation		score0	HPRD	18669648
S588	Phosphorylation		score0	HPRD	18669648
T593	Phosphorylation		score0	HPRD	17081983
S596	Phosphorylation		score0	HPRD	19651622, 18669648, 17081983
T598	Phosphorylation		score0	HPRD	17081983
S603	Phosphorylation		score0	HPRD	18088087, 17081983, 18452278, ...19651622, 18669648, 19415658, 20068231
S606	Phosphorylation		score0	HPRD	17322306, 18088087, 18452278, ...19651622, 18669648, 19415658, 20068231
S608	Phosphorylation		score0	HPRD	19651622, 18669648, 20068231, ...18452278
S613	Phosphorylation		score0	HPRD	19651622, 18669648, 17081983
S670	Phosphorylation		score0	HPRD	19651622, 18767875, 20058876, ...20068231
S673	Phosphorylation		score0	HPRD	17322306, 18088087, 16964243, ...18767875, 19664994, 19651622, 20058876, 18707149, 20068231
S689	Phosphorylation		score0	HPRD	18669648, 17081983
T693	Phosphorylation		score0	HPRD	18669648

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y64 Y88 K95 Y301 S397 T454 S494 T573 T598 S625 S661 T681 T693 T780	Variant Select all * A573 A693 A780 C64 F301 F494 F88 I454 I598 I681 I693 L397 L625 N95 P661 P693 S693	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:184 / bone cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y64	C64	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
Y88	F88	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
K95	N95	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y301	F301	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S397	L397	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T454	I454	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S494	F494	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T573	A573	Biomuta	[ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T598	I598	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S625	L625	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S661	*	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S661	P661	Biomuta	DOID:1319 / brain cancer [ cosmic ]
T681	I681	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T693	A693	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T693	I693	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T693	S693	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T693	P693	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T780	A780	Biomuta	DOID:184 / bone cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q05209 (PTPN12)

Protein Information

Interactive Sequence View

Q05209 (PTPN12) as Substrate

PTM sites affected in variants