iPTMnet Report for Q05193 (DNM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05193 / DYN1_HUMAN
Protein Name Dynamin-1
Gene Name Name: DNM1
Synonyms:DNM;
Organism Homo sapiens (Human)

PRO ID PR:Q05193
DAG View
PRO Name dynamin-1 (human)
Definition A dynamin-1 that is encoded in the genome of human.
Short Label hDNM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05193 (DNM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
R217 Methylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 9880482
K257 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
R271 Methylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
T438 Phosphorylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K598 Acetylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
Y669 Phosphorylation PhosphoSitePlus
T684 O-Glycosylation GlyGen 30379171, 34725712
Y732 Phosphorylation PhosphoSitePlus
S774 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 18088087, 15302935, 23908769, ...12855954, 17376771, 29668686
T776 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935, 18088087
S777 Phosphorylation phospho.ELM   PhosphoSitePlus 17437541, 17081983
S778 Phosphorylation P17252 (PRKCA) neXtProt   phospho.ELM   PhosphoSitePlus 18088087, 15302935, 12855954, ...17376771, 21195118, 17437541, 19605734
T780 Phosphorylation Q00535 (CDK5) neXtProt   phospho.ELM   PhosphoSitePlus 15302935, 17376771
S795 Phosphorylation Q13627 (DYRK1A) PhosphoSitePlus   Signor 15287745
S822 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
S857 Phosphorylation Q13627 (DYRK1A) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15287745, 22857010
Site PTM Type PTM Enzyme Score Source PMID
Y231 Phosphorylation P12931 (SRC) HPRD 9880482
T411 Phosphorylation HPRD 18491316
Y597 Phosphorylation P12931 (SRC) HPRD 9880482, 12011079
S774 Phosphorylation Q00535 (CDK5) HPRD 19651622, 18088087, 12855954
T776 Phosphorylation HPRD 19651622, 18088087, 17081983
S777 Phosphorylation HPRD 17081983
S778 Phosphorylation Q00535 (CDK5) HPRD 19651622, 18088087, 12855954
T780 Phosphorylation HPRD 19651622
S795 Phosphorylation P17252 (PRKCA) HPRD 10766777
Site PTM Type PTM Enzyme Score Source PMID
Y231 Phosphorylation P12931 (SRC) HPRD 9880482
T411 Phosphorylation HPRD 18491316
Y597 Phosphorylation P12931 (SRC) HPRD 9880482, 12011079
S774 Phosphorylation Q00535 (CDK5) HPRD 19651622, 18088087, 12855954
T776 Phosphorylation HPRD 19651622, 18088087, 17081983
S777 Phosphorylation HPRD 17081983
S778 Phosphorylation Q00535 (CDK5) HPRD 19651622, 18088087, 12855954
T780 Phosphorylation HPRD 19651622
S795 Phosphorylation P17252 (PRKCA) HPRD 10766777


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 C61 Biomuta DOID:1324 / lung cancer [ cosmic ]
R217 H217 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S261 Y261 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S264 P264 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R271 C271 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y354 C354 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y597 C597 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K598 N598 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y732 H732 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S822 P822 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]