Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05086 / UBE3A_HUMAN
Protein Name Ubiquitin-protein ligase E3A
Gene Name Name: UBE3A
Synonyms:E6AP;
Organism Homo sapiens (Human)

PRO ID PR:Q05086
DAG View
PRO Name ubiquitin-protein ligase E3A (human)
Definition A ubiquitin-protein ligase E3A that is encoded in the genome of human.
Short Label hUBE3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05086 (UBE3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K30 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
C198 S-Nitrosylation dbSNO 26338901
S199 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S218 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 19690332
K226 Ubiquitination PhosphoSitePlus
R294 Methylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
T342 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S372 O-Glycosylation GlyGen 23301498, 29351928
K373 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
T465 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
T479 Phosphorylation PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
Y659 Phosphorylation P00519 (ABL1) Signor   UniProt 23581475
K702 Ubiquitination PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
Y720 Phosphorylation PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
K822 Ubiquitination PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
K870 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S218 Phosphorylation HPRD 17525332, 18077418, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S195 Phosphorylation HPRD 17525332, 18077418, 20068231
T485 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 26255772
S489 Phosphorylation PhosphoSitePlus
Y636 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
S215 Phosphorylation HPRD 17525332, 18077418, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K71 N71 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S199 Y199 Biomuta DOID:363 / uterine cancer [ tcga ]
S199 F199 Biomuta DOID:1612 / breast cancer [ cosmic ]
S207 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K315 N315 Biomuta DOID:1324 / lung cancer [ cosmic ]
S372 L372 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ]
K420 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T471 K471 Biomuta DOID:3571 / liver cancer [ icgc ]
T479 K479 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T479 S479 Biomuta DOID:3070 / malignant glioma [ tcga ]
S512 G512 Biomuta DOID:2394 / ovarian cancer [ icgc ]