iPTMnet Report for Q04917 (YWHAH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04917 / 1433F_HUMAN
Protein Name 14-3-3 protein eta
Gene Name Name: YWHAH
Synonyms:YWHA1;
Organism Homo sapiens (Human)

PRO ID PR:Q04917
DAG View
PRO Name 14-3-3 protein eta (human)
Definition A 14-3-3 protein eta that is encoded in the genome of human.
Short Label hYWHAH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04917 (YWHAH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y20 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19690332, 33116123
S38 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K50 Methylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S58 Phosphorylation neXtProt 15883165
S59 Phosphorylation Q05655 (PRKCD) neXtProt   phospho.ELM   PhosphoSitePlus 9705322
S65 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
Y123 Phosphorylation PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T168 Phosphorylation HPRD   PhosphoSitePlus 20068231
S215 Phosphorylation HPRD 20068231
Y216 Phosphorylation HPRD   PhosphoSitePlus 20068231
K217 Acetylation PhosphoSitePlus
S219 Phosphorylation HPRD   PhosphoSitePlus 20068231
T220 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q04917 (YWHAH) S25 O43623 (SNAI2) unknown eFIP 33116123


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R42 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R42 Q42 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S65 N65 Biomuta DOID:363 / uterine cancer [ icgc ]
K77 N77 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y131 H131 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K143 Q143 Biomuta DOID:3571 / liver cancer [ cosmic, icgc, tcga ]
T168 M168 Biomuta DOID:363 / uterine cancer [ cosmic ]