iPTMnet Report for Q04864 (REL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04864 / REL_HUMAN
Protein Name Proto-oncogene c-Rel
Gene Name Name: REL
Organism Homo sapiens (Human)

PRO ID PR:Q04864
DAG View
PRO Name proto-oncogene c-Rel (human)
Definition A proto-oncogene c-Rel that is encoded in the genome of human.
Short Label hREL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04864 (REL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S3 Phosphorylation PhosphoSitePlus
Y6 Phosphorylation PhosphoSitePlus
K26 Sumoylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
T254 O-Glycosylation GlyGen 23301498, 33214551, 32574038, ...28228555, 29351928, 23982206, 27454154
T258 O-Glycosylation GlyGen 23301498, 33214551, 32574038, ...28228555, 29351928, 23982206, 27454154
T378 O-Glycosylation GlyGen 29351928
S382 O-Glycosylation GlyGen 29351928
S386 Phosphorylation PhosphoSitePlus
Y387 Phosphorylation PhosphoSitePlus
S390 O-Glycosylation GlyGen 32574038
S403 O-Glycosylation GlyGen 32574038
S409 O-Glycosylation GlyGen 29351928
R421 Methylation PhosphoSitePlus
T425 O-Glycosylation GlyGen 29351928
T433 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
S492 Phosphorylation phospho.ELM   PhosphoSitePlus 10823840
S503 Phosphorylation PhosphoSitePlus   UniProt 10823840
S516 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S557 Phosphorylation O14920 (IKBKB) , O15111 (CHUK) PhosphoSitePlus 17072339
Y597 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K26 E26 Biomuta DOID:4159 / skin cancer [ cosmic ]
K26 T26 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T258 I258 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S386 F386 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y387 H387 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y387 C387 Biomuta DOID:1324 / lung cancer [ cosmic ]
S390 P390 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S390 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S409 F409 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R421 H421 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R421 C421 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T425 A425 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S516 N516 Biomuta [ cosmic ]