Protein Information

Cytoscape View

UniProt AC / UniProt ID Q04771 / ACVR1_HUMAN
Protein Name Activin receptor type-1 precursor
Gene Name Name: ACVR1
Organism Homo sapiens (Human)

PRO ID PR:Q04771
DAG View
PRO Name activin receptor type-1 (human)
Definition An activin receptor type-1 that is encoded in the genome of human.
Short Label hACVR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q04771 (ACVR1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T203 Phosphorylation PhosphoSitePlus   RLIMS-P 25354296
S226 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus   UniProt 19369195
K504 Ubiquitination PhosphoSitePlus

Q04771 (ACVR1) as PTM Enzyme

Substrate Site Score Source PMID
Q15797-1 (SMAD1) S462 HPRD 9748228, 9136927, 10085121
Q15797-1 (SMAD1) S463 HPRD 19651622, 9748228, 9136927, ...10085121
Q15797-1 (SMAD1) S465 HPRD 19651622, 9748228, 9136927, ...10085121

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T203 K203 Biomuta DOID:3571 / liver cancer [ icgc ]
K504 I504 Biomuta DOID:11934 / head and neck cancer [ tcga ]