Protein Information

Cytoscape View

UniProt AC / UniProt ID Q04760 / LGUL_HUMAN
Protein Name Lactoylglutathione lyase
Gene Name Name: GLO1
Organism Homo sapiens (Human)

PRO ID PR:Q04760
DAG View
PRO Name lactoylglutathione lyase (human)
Definition A lactoylglutathione lyase that is encoded in the genome of human.
Short Label hGLO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q04760 (GLO1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 20454679, 25944712
T35 Phosphorylation PhosphoSitePlus
R38 Methylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
C61 S-Nitrosylation dbSNO 19483679
K88 Ubiquitination PhosphoSitePlus
T107 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus   UniProt 19199007
Y136 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
C139 S-Nitrosylation dbSNO 25040305
K140 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K148 Acetylation PhosphoSitePlus   UniProt 19608861
K148 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T35 N35 Biomuta DOID:3571 / liver cancer [ icgc ]
S45 * Biomuta DOID:3571 / liver cancer [ icgc ]
K60 T60 Biomuta DOID:10534 / stomach cancer [ tcga ]
K88 R88 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
Y136 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S137 C137 Biomuta DOID:1324 / lung cancer [ tcga ]
K148 R148 Biomuta DOID:9256 / colorectal cancer [ icgc ]