Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04759 / KPCT_HUMAN
Protein Name Protein kinase C theta type
Gene Name Name: PRKCQ
Synonyms:PRKCT;
Organism Homo sapiens (Human)

PRO ID PR:Q04759
DAG View
PRO Name protein kinase C theta type (human)
Definition A protein kinase C theta type that is encoded in the genome of human.
Short Label hPRKCQ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04759 (PRKCQ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y28 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
T51 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
Y90 Phosphorylation P06239 (LCK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10652356
K110 Ubiquitination PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
T219 Phosphorylation Q04759 (PRKCQ) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 16252004
K223 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus   UniProt 18691976
K355 Ubiquitination PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K384 Acetylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus
T538 Phosphorylation Q13131 (PRKAA1) , Q8IVH8 (MAP4K3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16252004, 32600444, 21983831, ...27633441, 17192257, 25638159, 15364937, 28394935, 11772397, 18055570, 22330070
T542 Phosphorylation PhosphoSitePlus
Y545 Phosphorylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
S676 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 16252004, 23186163, 19369195, ...21795397, 11772397
S685 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17192257, 19690332
S695 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 16252004, 21406692, 23186163, ...19369195, 32425555, 15364937, 18691976, 17192257, 24275569, 11772397
Site PTM Type PTM Enzyme Score Source PMID
Y90 Phosphorylation P06239 (LCK) HPRD 10652356
T219 Phosphorylation Q04759 (PRKCQ) HPRD 16252004
S348 Phosphorylation HPRD 18691976
T536 Phosphorylation HPRD 18691976
T538 Phosphorylation HPRD 11772397
S676 Phosphorylation HPRD 19651622, 11772397, 18691976
S685 Phosphorylation HPRD 18691976, 17192257
S695 Phosphorylation HPRD   PRO 18691976, 20230923, 15364937, ...19651622, 11772397, 12473184


Q04759 (PRKCQ) as PTM Enzyme



Substrate Site Score Source PMID
O14920-1 (IKBKB) S177 HPRD 17363905
O14920-1 (IKBKB) S181 HPRD 17363905
O14974 (PPP1R12A) T853 PhosphoSitePlus 19255442
O15111 (CHUK) S176 HPRD 17363905
O15111 (CHUK) S180 HPRD 17363905
O15530 (PDPK1) S501 neXtProt 19047061
O15530 (PDPK1) S529 neXtProt 19047061
O43516 (WIPF1) S488 HPRD   PhosphoSitePlus 16460447, 12504004
O95267 (RASGRP1) T184 PhosphoSitePlus 15657177
P01116-2 (KRAS) S181 PhosphoSitePlus 16483930
P10588 (NR2F6) S83 PhosphoSitePlus 18701084
P15311 (EZR) T567 PhosphoSitePlus 19255442
P15407 (FOSL1) T217 Signor 27816489
P15407 (FOSL1) T223 PhosphoSitePlus 22286759
P15407 (FOSL1) T227 Signor 27816489
P15407 (FOSL1) T230 PhosphoSitePlus 22286759
P15407 (FOSL1) S265 PhosphoSitePlus 22286759
P26038 (MSN) T558 HPRD   PhosphoSitePlus   Signor 19255442, 9516463, 9856983
P29474 (NOS3) T495 Signor 24379783
P32942 (ICAM3) S518 HPRD   PhosphoSitePlus   Signor 9268366
P35236 (PTPN7) S44 PhosphoSitePlus 16479000
P35236 (PTPN7) S246 PhosphoSitePlus 16479000
P35241 (RDX) T564 PhosphoSitePlus 19255442
P35568 (IRS1) S1101 HPRD   neXtProt   PhosphoSitePlus 15364919, 23352416
P41594-2 (GRM5) S840 HPRD 15894802
Q04759 (PRKCQ) T219 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 16252004
Q09472 (EP300) S384 neXtProt 18250452
Q13191 (CBLB) S282 neXtProt   PhosphoSitePlus 19549985
Q15052 (ARHGEF6) S225 PhosphoSitePlus 25694429
Q15052 (ARHGEF6) S488 PhosphoSitePlus 25694429
Q3V6T2-2 (CCDC88A) S1689 neXtProt 23509302
Q3V6T2 (CCDC88A) S1690 PhosphoSitePlus 23509302
Q5JVS0-1 (HABP4) T354 HPRD   PhosphoSitePlus   Signor 14699138
Q5JVS0-1 (HABP4) T375 HPRD   PhosphoSitePlus   Signor 14699138
Q8IV61 (RASGRP3) T133 PhosphoSitePlus   Signor 15545601, 15657177
Q92934 (BAD) S75 neXtProt   PhosphoSitePlus 20179209, 11342610
Q92934 (BAD) S99 neXtProt   PhosphoSitePlus 20179209, 11342610
Q9BXL7 (CARD11) S559 neXtProt   PhosphoSitePlus 16356855, 16356856
Q9BXL7 (CARD11) S644 neXtProt   Signor 21157432, 16356855
Q9BXL7 (CARD11) S652 neXtProt 16356855
Q9UEW8-1 (STK39) S309 HPRD   neXtProt   PhosphoSitePlus 10980603, 14988727
Q9UEW8-1 (STK39) S323 HPRD   PhosphoSitePlus 10980603, 14988727
Q9Y4G8 (RAPGEF2) S960 neXtProt   PhosphoSitePlus   Signor 18796635


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048920 (hPRKCQ/Phos:1) pY90 PRO
PR:000048921 (hPRKCQ/Phos:2) pY90,pT219,pT538,pS676,pS695 PRO
PR:000048922 (hPRKCQ/Phos:3) pY90,pT538,pS676,pS695 PRO
PR:000049857 (hPRKCQ/Phos:4) pS695 PRO 11772397, 12473184, 15364937


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000044747 (mBAD/iso:1/UnMod) Interaction PR:Q04759 (hPRKCQ) PRO 17011751


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K276 N276 Biomuta DOID:1909 / melanoma [ cosmic ]
S370 Y370 Biomuta DOID:363 / uterine cancer [ tcga ]
K400 M400 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K409 N409 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T538 N538 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
Y545 C545 Biomuta DOID:1612 / breast cancer [ cosmic ]
K645 N645 Biomuta DOID:363 / uterine cancer [ tcga ]
K672 N672 Biomuta DOID:0070003 / blastoma [ icgc ]
S676 * Biomuta DOID:363 / uterine cancer [ tcga ]
S695 F695 Biomuta DOID:1909 / melanoma [ icgc, tcga ]