Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04726 / TLE3_HUMAN
Protein Name Transducin-like enhancer protein 3
Gene Name Name: TLE3
Synonyms:KIAA1547;
Organism Homo sapiens (Human)

PRO ID PR:Q04726
DAG View
PRO Name transducin-like enhancer protein 3 (human)
Definition A transducin-like enhancer protein 3 that is encoded in the genome of human.
Short Label hTLE3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04726 (TLE3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
R6 Methylation PhosphoSitePlus
K19 Methylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S201 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S203 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 16964243, ...15302935, 18669648, 23186163, 19690332, 20068231, 17081983
S205 Phosphorylation PhosphoSitePlus
S207 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 23186163
S211 Phosphorylation PhosphoSitePlus   UniProt 23186163
K213 Acetylation PhosphoSitePlus
R215 Methylation PhosphoSitePlus
S217 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
Y220 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
Y238 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S240 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 18669648, ...17081983
S245 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 17081983
S253 Phosphorylation PhosphoSitePlus
T259 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
S263 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 20068231
S267 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 20068231
S278 Phosphorylation PhosphoSitePlus
T285 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S286 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 19690332
S289 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S292 Phosphorylation PhosphoSitePlus
S294 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S295 Phosphorylation PhosphoSitePlus
T296 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S299 Phosphorylation PhosphoSitePlus
K300 Acetylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S311 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T312 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K316 Ubiquitination PhosphoSitePlus
S317 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
T319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T321 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T328 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...19690332, 20068231
S332 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
T334 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18220336, ...18669648, 19690332, 20068231
R338 Methylation PhosphoSitePlus
S413 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S417 Phosphorylation PhosphoSitePlus
R430 Methylation PhosphoSitePlus
K445 Acetylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
R643 Methylation PhosphoSitePlus
Y694 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
K720 Acetylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
K764 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S201 Phosphorylation HPRD 17287340
S203 Phosphorylation HPRD 19413330, 17322306, 18491316, ...17287340, 16964243, 18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
S205 Phosphorylation HPRD 19664995
S207 Phosphorylation HPRD 18669648, 17287340, 17081983, ...20068231
S211 Phosphorylation HPRD 17081983
S217 Phosphorylation HPRD 17322306, 18212344, 20068231
Y238 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S240 Phosphorylation HPRD 19651622, 18669648, 15302935, ...18452278
S245 Phosphorylation HPRD 19651622, 15302935, 20068231, ...18452278
S253 Phosphorylation HPRD 17081983
T259 Phosphorylation HPRD 17081983, 19664994, 18452278, ...19651622, 18669648, 20068231
S263 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
S267 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
T285 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995
S286 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20058876, 19664994, 19664995, 19651622, 17322306, 18669648, 18767875, 20068231
S289 Phosphorylation HPRD 19413330, 18669648
S292 Phosphorylation HPRD 20068231
S294 Phosphorylation HPRD 18669648
S295 Phosphorylation HPRD 19664995
T296 Phosphorylation HPRD 18669648, 20068231
S299 Phosphorylation HPRD 19413330
S311 Phosphorylation HPRD 18669648
T312 Phosphorylation HPRD 18669648
S317 Phosphorylation HPRD 18669648
T319 Phosphorylation HPRD 18669648, 20068231
T321 Phosphorylation HPRD 18669648
T328 Phosphorylation HPRD 19413330, 19664994, 19664995, ...19651622, 18669648, 20068231
T331 Phosphorylation HPRD 20068231
S332 Phosphorylation HPRD 19664995
T333 Phosphorylation HPRD 20068231
T334 Phosphorylation HPRD 19413330, 16964243, 19664994, ...19651622, 18669648, 20068231
S413 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T328 Phosphorylation PhosphoSitePlus
T334 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K343 Acetylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
R422 Methylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049465 (hTLE3/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R6 T6 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R215 W215 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S289 T289 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S299 P299 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K309 E309 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K309 T309 Biomuta DOID:363 / uterine cancer [ tcga ]
T333 K333 Biomuta DOID:3571 / liver cancer [ icgc ]
R430 Q430 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R430 W430 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S515 N515 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
R643 H643 Biomuta DOID:1909 / melanoma [ cosmic ]