iPTMnet Report for Q04725 (TLE2)
Protein Information
UniProt AC / UniProt ID | Q04725 / TLE2_HUMAN |
Protein Name | Transducin-like enhancer protein 2 |
Gene Name | Name: TLE2 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q04725 |
PRO Name | transducin-like enhancer protein 2 (human) |
Definition | A transducin-like enhancer protein 2 that is encoded in the genome of human. |
Short Label | hTLE2 |
Category | organism-gene |
Q04725 (TLE2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Ubiquitination | score1 | PRO | ||||
K29 | Ubiquitination | score1 | PhosphoSitePlus | |||
K53 | Ubiquitination | score1 | PhosphoSitePlus | |||
K82 | Ubiquitination | score1 | PhosphoSitePlus | |||
S182 | Phosphorylation | score1 | PhosphoSitePlus | |||
S193 | Phosphorylation | score1 | PhosphoSitePlus | |||
S195 | Phosphorylation | score1 | PhosphoSitePlus | |||
S199 | Phosphorylation | score1 | PhosphoSitePlus | |||
S271 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S281 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
S301 | O-Glycosylation | score1 | GlyGen | 34019948, 28657654 | ||
T334 | O-Glycosylation | score1 | GlyGen | 34019948, 28657654 | ||
K477 | Ubiquitination | score1 | PhosphoSitePlus | |||
K481 | Ubiquitination | score1 | PhosphoSitePlus | |||
K491 | Ubiquitination | score1 | PhosphoSitePlus | |||
K510 | Ubiquitination | score1 | PhosphoSitePlus | |||
K540 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y665 | Phosphorylation | score1 | PhosphoSitePlus | |||
S672 | Phosphorylation | score1 | PhosphoSitePlus | |||
S676 | Phosphorylation | score1 | PhosphoSitePlus | |||
S681 | Phosphorylation | score1 | PhosphoSitePlus | |||
K691 | Acetylation | score1 | PhosphoSitePlus | |||
K691 | Ubiquitination | score1 | PhosphoSitePlus | |||
K710 | Ubiquitination | score1 | PhosphoSitePlus | |||
S712 | Phosphorylation | score1 | PhosphoSitePlus | |||
K725 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y726 | Phosphorylation | score1 | PhosphoSitePlus | |||
T729 | Phosphorylation | score1 | PhosphoSitePlus | |||
S731 | Phosphorylation | score1 | PhosphoSitePlus | |||
K734 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K29 | N29 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K82 | R82 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K287 | N287 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S301 | F301 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T334 | M334 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K481 | N481 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K510 | T510 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y726 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S731 | L731 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K734 | N734 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |