Protein Information

Cytoscape View

UniProt AC / UniProt ID Q04725 / TLE2_HUMAN
Protein Name Transducin-like enhancer protein 2
Gene Name Name: TLE2
Organism Homo sapiens (Human)

PRO ID PR:Q04725
DAG View
PRO Name transducin-like enhancer protein 2 (human)
Definition A transducin-like enhancer protein 2 that is encoded in the genome of human.
Short Label hTLE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q04725 (TLE2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K29 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
S271 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S281 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K287 Ubiquitination PhosphoSitePlus
S301 O-Glycosylation GlyGen 28657654
T334 O-Glycosylation GlyGen 28657654
K477 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
Y665 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
K691 Acetylation PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
Y726 Phosphorylation PhosphoSitePlus
T729 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S271 Phosphorylation HPRD 18669648
S281 Phosphorylation HPRD 18669648


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049464 (hTLE2/UbiqLys+) ub PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K82 R82 Biomuta DOID:1909 / melanoma [ cosmic ]
T334 M334 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K510 T510 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y665 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y726 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K734 N734 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]