iPTMnet Report for Q04721 (NOTCH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04721 / NOTC2_HUMAN
Protein Name Neurogenic locus notch homolog protein 2 precursor
Gene Name Name: NOTCH2
Organism Homo sapiens (Human)

PRO ID PR:Q04721
DAG View
PRO Name neurogenic locus notch homolog protein 2 (human)
Definition A neurogenic locus notch homolog protein 2 that is encoded in the genome of human.
Short Label hNOTCH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04721 (NOTCH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N46 N-Glycosylation GlyGen 23090970, 29741879, 24190977
T172 O-Glycosylation GlyGen 32574038, 29249144
T175 O-Glycosylation GlyGen 32574038, 31492838, 29249144, ...34019948, 35289036, 35254053, 28657654
S359 Phosphorylation PhosphoSitePlus
T436 Phosphorylation HPRD   PhosphoSitePlus 20058876
S667 O-Glycosylation GlyGen 34846842, 32574038, 31492838, ...29249144, 34019948, 35289036, 35254053, 28657654
T675 O-Glycosylation GlyGen 32574038, 32938750, 31492838, ...29249144, 34019948, 35289036, 35254053, 28657654
T942 O-Glycosylation GlyGen 32574038, 31492838, 29249144, ...34019948, 35289036, 35254053, 28657654
S1376 O-Glycosylation GlyGen 34846842
S1381 O-Glycosylation GlyGen 34846842
S1419 O-Glycosylation GlyGen 30459171
T1420 O-Glycosylation GlyGen 30459171
K1580 Acetylation PhosphoSitePlus
K1596 Acetylation PhosphoSitePlus
K1602 Ubiquitination PhosphoSitePlus
K1622 Ubiquitination PhosphoSitePlus
S1670 Phosphorylation PhosphoSitePlus
K1705 Ubiquitination PhosphoSitePlus
S1708 Phosphorylation PhosphoSitePlus
T1716 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1722 Phosphorylation PhosphoSitePlus
K1738 Ubiquitination PhosphoSitePlus
S1745 Phosphorylation PhosphoSitePlus
K1770 Ubiquitination PhosphoSitePlus
S1778 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18767875, 19691289, ...18452278, 18669648, 19690332, 20068231
T1802 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1804 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T1808 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
T1830 Phosphorylation PhosphoSitePlus
S1836 Phosphorylation PhosphoSitePlus
S1841 Phosphorylation HPRD   phospho.ELM 18669648, 17081983, 18452278
S1842 Phosphorylation HPRD 17081983, 20068231
S1845 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18452278, 18669648, ...19690332, 20068231
S1854 Phosphorylation HPRD 17081983
S1855 Phosphorylation HPRD 17081983
Y2023 Phosphorylation HPRD 20068231
T2039 Phosphorylation PhosphoSitePlus
T2068 Phosphorylation P49841 (GSK3B) HPRD   Signor 12794074
S2070 Phosphorylation P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12794074, 18669648, 15302935, ...20068231
T2074 Phosphorylation P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   Signor 12794074, 18669648
T2077 Phosphorylation HPRD 20068231
S2078 Phosphorylation HPRD   PhosphoSitePlus 11577080
S2081 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S2090 Phosphorylation PhosphoSitePlus
S2093 Phosphorylation P49841 (GSK3B) HPRD   PhosphoSitePlus   Signor 12794074
T2097 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K2101 Ubiquitination PhosphoSitePlus
K2102 Ubiquitination PhosphoSitePlus
S2115 Phosphorylation PhosphoSitePlus
K2121 Ubiquitination PhosphoSitePlus
S2129 Phosphorylation PhosphoSitePlus
S2134 Phosphorylation PhosphoSitePlus
S2136 Phosphorylation PhosphoSitePlus
T2295 Phosphorylation HPRD 20068231
T2296 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y2340 Phosphorylation PhosphoSitePlus
Y2373 Phosphorylation PhosphoSitePlus
T2385 Phosphorylation PhosphoSitePlus
S2388 Phosphorylation PhosphoSitePlus
Y2470 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N46 S46 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11615 / penile cancer [ cosmic ]
S359 F359 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1381 N1381 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1419 R1419 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1420 I1420 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1580 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K1622 N1622 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1708 C1708 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1708 F1708 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
S1722 G1722 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1778 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1804 L1804 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
T1808 I1808 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1836 F1836 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1836 A1836 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1841 N1841 Biomuta [ cosmic ]
S1841 I1841 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1841 R1841 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1842 P1842 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1842 T1842 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1845 R1845 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S1854 P1854 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y2023 C2023 Biomuta DOID:1612 / breast cancer [ cosmic ]
T2039 A2039 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2078 F2078 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2081 T2081 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2090 F2090 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2102 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K2121 N2121 Biomuta DOID:3565 / meningioma [ cosmic ]
S2136 C2136 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2136 G2136 Biomuta DOID:363 / uterine cancer [ icgc ]
T2295 A2295 Biomuta [ cosmic ]
Y2340 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y2340 C2340 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2388 L2388 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S2388 * Biomuta DOID:3565 / meningioma [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]