Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04656 / ATP7A_HUMAN
Protein Name Copper-transporting ATPase 1
Gene Name Name: ATP7A
Synonyms:MC1,MNK;
Organism Homo sapiens (Human)

PRO ID PR:Q04656
DAG View
PRO Name copper-transporting ATPase 1 (human)
Definition A copper-transporting ATPase 1 that is encoded in the genome of human.
Short Label hATP7A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04656 (ATP7A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S147 Phosphorylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus   UniProt 23186163
K155 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K226 Acetylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K239 Acetylation PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus   UniProt 23186163
S272 Phosphorylation PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus   UniProt 23186163
S330 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
Y343 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus   UniProt 23186163
S359 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
Y471 Phosphorylation PhosphoSitePlus
T476 Phosphorylation PhosphoSitePlus
Y517 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
Y594 Phosphorylation PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S827 Phosphorylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
K1039 Ubiquitination PhosphoSitePlus
K1045 Ubiquitination PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
K1132 Ubiquitination PhosphoSitePlus
T1204 Phosphorylation PhosphoSitePlus
T1212 Phosphorylation PhosphoSitePlus
S1306 Phosphorylation PhosphoSitePlus
K1412 Ubiquitination PhosphoSitePlus
S1424 Phosphorylation PhosphoSitePlus
S1430 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1432 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1435 Phosphorylation PhosphoSitePlus
S1444 Phosphorylation PhosphoSitePlus
S1447 Phosphorylation PhosphoSitePlus
K1449 Ubiquitination PhosphoSitePlus
Y1459 Phosphorylation PhosphoSitePlus
S1460 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1463 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1466 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1469 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1471 Ubiquitination PhosphoSitePlus
S1473 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1476 Phosphorylation PhosphoSitePlus
T1479 Phosphorylation PhosphoSitePlus
S1480 Phosphorylation PhosphoSitePlus
S1486 Phosphorylation PhosphoSitePlus
T1498 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K195 * Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y273 C273 Biomuta DOID:3070 / malignant glioma [ tcga ]
T278 P278 Biomuta DOID:1612 / breast cancer [ icgc ]
S325 T325 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S330 F330 Biomuta DOID:1909 / melanoma [ tcga ]
S339 L339 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S349 C349 Biomuta DOID:363 / uterine cancer [ tcga ]
S353 R353 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S355 * Biomuta DOID:1324 / lung cancer [ tcga ]
S1424 N1424 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1432 T1432 Biomuta DOID:1612 / breast cancer [ tcga ]
S1435 N1435 Biomuta DOID:1324 / lung cancer [ tcga ]
S1460 R1460 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S1466 P1466 Biomuta DOID:3070 / malignant glioma [ tcga ]
S1466 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]