Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04637 / IF4G1_HUMAN
Protein Name Eukaryotic translation initiation factor 4 gamma 1
Gene Name Name: EIF4G1
Synonyms:EIF4F,EIF4G,EIF4GI;
Organism Homo sapiens (Human)

PRO ID PR:Q04637
DAG View
PRO Name eukaryotic translation initiation factor 4 gamma 1 (human)
Definition A eukaryotic translation initiation factor 4 gamma 1 that is encoded in the genome of human.
Short Label hEIF4G1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04637 (EIF4G1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
R48 Methylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
R55 Methylation PhosphoSitePlus
S61 O-Glycosylation PhosphoSitePlus
R65 Methylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus   UniProt 24129315
Y103 Phosphorylation PhosphoSitePlus
R110 Methylation PhosphoSitePlus   UniProt 24129315
T179 Phosphorylation PhosphoSitePlus
K190 Acetylation PhosphoSitePlus
T202 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231
S204 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
T205 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 18452278
T207 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18452278, ...19651622, 18669648
T211 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648
T223 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S276 Phosphorylation HPRD 20068231
T301 Phosphorylation HPRD   PhosphoSitePlus 20068231
S304 Phosphorylation HPRD 20068231
Y311 Phosphorylation PhosphoSitePlus
S314 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20058876, 19664994, 18452278, ...24275569, 20068231
T318 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 18452278
S343 Phosphorylation PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
K519 Sumoylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K535 Acetylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
Y594 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
K597 Ubiquitination PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
T647 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18847512, ...20068231
T667 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
R675 Methylation PhosphoSitePlus
T676 Phosphorylation PhosphoSitePlus
R681 Methylation PhosphoSitePlus
R685 Methylation PhosphoSitePlus   UniProt 24129315
R694 Methylation PhosphoSitePlus   UniProt 24129315
R702 Methylation PhosphoSitePlus
S704 Phosphorylation HPRD   PhosphoSitePlus 19651622
K732 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
T757 Phosphorylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
R877 Methylation PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
S895 Phosphorylation Q13177 (PAK2) PhosphoSitePlus 16281055
K900 Ubiquitination PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
K925 Ubiquitination PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
K950 Acetylation PhosphoSitePlus
K950 Ubiquitination PhosphoSitePlus
R954 Methylation PhosphoSitePlus
K964 Acetylation PhosphoSitePlus
K964 Ubiquitination PhosphoSitePlus
K967 Ubiquitination PhosphoSitePlus
K1019 Ubiquitination PhosphoSitePlus
K1026 Methylation PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
S1028 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
R1031 Methylation PhosphoSitePlus
R1032 Methylation PhosphoSitePlus   UniProt 24129315
R1042 Methylation PhosphoSitePlus   UniProt 24129315
T1054 Phosphorylation PhosphoSitePlus
K1059 Methylation PhosphoSitePlus
K1059 Ubiquitination PhosphoSitePlus
T1066 Phosphorylation PhosphoSitePlus
K1071 Ubiquitination PhosphoSitePlus
T1073 Phosphorylation PhosphoSitePlus
K1074 Ubiquitination PhosphoSitePlus
S1077 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 24979134, 18669648, 23186163, ...18212344
S1080 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1092 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 24979134, 21406692, 23186163, ...19651622, 18669648, 20166139, 20068231, 17924679
K1095 Acetylation PhosphoSitePlus   UniProt 19608861
K1095 Methylation PhosphoSitePlus
S1097 Phosphorylation PhosphoSitePlus
S1098 Phosphorylation HPRD   PhosphoSitePlus 19664995
S1101 Phosphorylation HPRD   PhosphoSitePlus 19664995
K1104 Methylation PhosphoSitePlus
S1106 Phosphorylation PhosphoSitePlus
S1110 Phosphorylation PhosphoSitePlus
T1117 Phosphorylation PhosphoSitePlus
T1119 Phosphorylation PhosphoSitePlus
R1138 Methylation PhosphoSitePlus
S1144 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1145 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
S1147 Phosphorylation P41279 (MAP3K8) HPRD   PRO   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19804365, 20068231, 20068230
R1166 Methylation PhosphoSitePlus
T1179 Phosphorylation PhosphoSitePlus
S1185 Phosphorylation P17252 (PRKCA) HPRD   neXtProt   PhosphoSitePlus   UniProt 21576361, 21406692, 23186163, ...17081983, 19691289, 18452278, 18669648, 20166139, 20068231
S1187 Phosphorylation HPRD   PRO   PhosphoSitePlus   UniProt 19664995, 21406692, 23186163, ...18212344, 19691289, 18452278, 18669648, 20166139, 19415658, 20068231
K1188 Acetylation PhosphoSitePlus
K1188 Ubiquitination PhosphoSitePlus
S1194 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
S1199 Phosphorylation HPRD   PhosphoSitePlus 19651622
S1209 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17322306, 21406692, 18088087, ...18212344, 19651622, 18669648, 23186163, 20166139, 17287340, 20068231
T1211 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 20166139, 21406692, ...20068231
R1216 Methylation PhosphoSitePlus
S1231 Phosphorylation P06493 (CDK1) HPRD   PRO   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18212344, 18691976, 16964243, 18767875, 17081983, 20058876, 19664995, 19651622, 17322306, 19664994, 18669648, 24248602, 19415658, 20068231, 17924679
K1234 Ubiquitination PhosphoSitePlus
S1238 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163
K1244 Acetylation PhosphoSitePlus
K1244 Ubiquitination PhosphoSitePlus
Y1253 Phosphorylation PhosphoSitePlus
C1265 S-Nitrosylation dbSNO 26338901
K1404 Ubiquitination PhosphoSitePlus
K1421 Ubiquitination PhosphoSitePlus
Y1424 Phosphorylation PhosphoSitePlus
T1425 Phosphorylation PhosphoSitePlus
S1430 Phosphorylation PhosphoSitePlus
R1436 Methylation PhosphoSitePlus
K1452 Ubiquitination PhosphoSitePlus
K1513 Ubiquitination PhosphoSitePlus
Y1526 Phosphorylation PhosphoSitePlus
T1534 Phosphorylation PhosphoSitePlus
Y1550 Phosphorylation PhosphoSitePlus
K1567 Ubiquitination PhosphoSitePlus
K1580 Ubiquitination PhosphoSitePlus
T1583 Phosphorylation PhosphoSitePlus
S1596 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 18767875, ...19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T165 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
Y554 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus
T1139 Phosphorylation PhosphoSitePlus
S1145 Phosphorylation PhosphoSitePlus
S1147 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T38 Phosphorylation HPRD 19651622, 18669648, 20068231
S40 Phosphorylation HPRD 19651622, 20068231
T41 Phosphorylation HPRD 19413330, 18669648, 18452278
T43 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18452278
T47 Phosphorylation HPRD 19651622, 18669648
T59 Phosphorylation HPRD 18669648
S112 Phosphorylation HPRD 20068231
T137 Phosphorylation HPRD 20068231
S140 Phosphorylation HPRD 20068231
S150 Phosphorylation HPRD 19664994, 20058876, 20068231, ...18452278
T154 Phosphorylation HPRD 19651622, 17081983, 18452278
Y430 Phosphorylation HPRD 15592455
T483 Phosphorylation HPRD 18669648, 20068231
S540 Phosphorylation HPRD 19651622
S864 Phosphorylation HPRD 20068231
S913 Phosphorylation HPRD 18669648, 18212344
S916 Phosphorylation HPRD 17081983
S928 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231, 17924679
S934 Phosphorylation HPRD 19664995
S937 Phosphorylation HPRD 19664995
S980 Phosphorylation HPRD 20068231
S981 Phosphorylation HPRD 17081983, 20068231
S983 Phosphorylation HPRD 17081983, 20068231, 20068230
S1021 Phosphorylation HPRD 17081983, 19691289, 18452278, ...18669648, 20166139, 20068231
S1023 Phosphorylation HPRD 19664995, 18212344, 19691289, ...18452278, 18669648, 20166139, 19415658, 20068231
S1030 Phosphorylation HPRD 19651622
S1035 Phosphorylation HPRD 19651622
S1045 Phosphorylation HPRD 17322306, 18088087, 18212344, ...19651622, 18669648, 20166139, 17287340, 20068231
T1047 Phosphorylation HPRD 19651622, 20166139, 20068231
S1067 Phosphorylation HPRD 19413330, 18691976, 18212344, ...20058876, 19664994, 19664995, 19651622, 17322306, 18669648, 18767875, 19415658, 20068231, 17924679
S1074 Phosphorylation HPRD 19413330
S1432 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
R685 Methylation PhosphoSitePlus
R694 Methylation PhosphoSitePlus
R703 Methylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus
S1148 Phosphorylation PhosphoSitePlus
S1186 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) PhosphoSitePlus 23263986
S1239 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 23263986


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047270 (hEIF4G1/Phos:1) pS1147,pS1187,pS1231 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R48 S48 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R55 W55 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R65 L65 Biomuta DOID:3571 / liver cancer [ icgc ]
R73 H73 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R110 H110 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T179 M179 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T179 A179 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S204 T204 Biomuta DOID:363 / uterine cancer [ tcga ]
T211 M211 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T223 M223 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ tcga ]
S353 C353 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K597 N597 Biomuta DOID:2994 / germ cell cancer [ tcga ]
K602 N602 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:3571 / liver cancer [ icgc ]
R675 Q675 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R681 H681 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R694 C694 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
T757 I757 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S766 F766 Biomuta DOID:1909 / melanoma [ tcga ]
K795 N795 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R877 * Biomuta DOID:9256 / colorectal cancer [ tcga ]
R954 * Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
R954 Q954 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K964 T964 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R1031 H1031 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R1042 H1042 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
R1042 C1042 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T1066 P1066 Biomuta DOID:1612 / breast cancer [ icgc ]
S1077 F1077 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
R1166 Q1166 Biomuta DOID:363 / uterine cancer [ tcga ]
R1166 L1166 Biomuta DOID:3571 / liver cancer [ icgc ]
S1209 T1209 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
R1216 C1216 Biomuta DOID:1324 / lung cancer [ tcga ]
R1216 S1216 Biomuta DOID:363 / uterine cancer [ tcga ]
S1238 C1238 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K1244 N1244 Biomuta DOID:363 / uterine cancer [ tcga ]
T1425 I1425 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T1534 N1534 Biomuta DOID:1324 / lung cancer [ cosmic ]