Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04206 / TF65_HUMAN
Protein Name Transcription factor p65
Gene Name Name: RELA
Synonyms:NFKB3;
Organism Homo sapiens (Human)

PRO ID PR:Q04206
DAG View
PRO Name transcription factor p65 (human)
Definition A transcription factor p65 that is encoded in the genome of human.
Short Label hRELA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04206 (RELA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K37 Methylation PhosphoSitePlus
K37 Sumoylation PhosphoSitePlus
C38 S-Nitrosylation dbSNO 17720813, 22178444
S42 Phosphorylation PhosphoSitePlus   RLIMS-P 27466442
S45 Phosphorylation PhosphoSitePlus   RLIMS-P 27466442
K56 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
S75 Phosphorylation RLIMS-P 24807716
K79 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus   UniProt 12419806
K122 Ubiquitination PhosphoSitePlus
K123 Acetylation PhosphoSitePlus   UniProt 12419806
K123 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus   RLIMS-P 22715377, 27466442
T136 Phosphorylation PhosphoSitePlus
R174 Methylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
R187 Methylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus   RLIMS-P 17991436
K218 Acetylation PhosphoSitePlus   UniProt 12456660
K218 Methylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K221 Acetylation PhosphoSitePlus   UniProt 12456660
K221 Methylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus   RLIMS-P 27466442
S240 Phosphorylation RLIMS-P 22715377, 27466442
T254 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26729520, 14690596, 26461058
S261 Phosphorylation PhosphoSitePlus   RLIMS-P 27466442
S269 Phosphorylation PhosphoSitePlus   RLIMS-P 27466442
S276 Phosphorylation O75676 (RPS6KA4) , P11309 (PIM1) , P17612 (PRKACA) , O94806 (PRKD3) , O75582 (RPS6KA5) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 17959673, 21107198, 17008051, ...20562110, 23118497, 17576778, 20504937, 18621420, 18424438, 24957606, 25520509, 21765477, 21832251, 22778400, 19933278, 17692505, 17617622, 18627520, 21935477, 21182083, 21492457, 27221592, 20406326, 27679610, 14713228, 23624258, 11931769, 24019758, 19910110, 28317833, 19197368, 20204068, 14711835, 20065107, 19201908, 19285061, 22733812, 18062909, 29388696, 17548605, 24349042, 18070609, 16283237, 23784084, 24844121, 16806820, 21820422, 24216290, 18501560, 21900162, 19706715, 28012741, 21556136, 23536830, 19288477, 18241676, 17397830, 23812431, 12628924, 9660950, 17911635, 20138622, 26461058, 19135383, 18310089, 18276112, 22797919, 22996371, 19038492, 21228323, 17991436, 20194077, 21334436, 17317104, 19291859, 20686703, 24023820, 17495961, 26463037, 18178962, 25055998, 29601651, 27721021, 19789307, 17108032, 25197166, 24630926, 21723926, 17183360, 19911008
S281 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17991436, 15516339
T305 O-Glycosylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus   RLIMS-P 28416608
K310 Acetylation PhosphoSitePlus   UniProt 19608861, 17000776, 12456660, ...16135789, 19103749
K310 Methylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
S311 Phosphorylation Q05513 (PRKCZ) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 21515635, 27466442, 26729520, ...20952659, 28004974, 17183360, 12881425, 15210811, 21131967, 19751727
K314 Acetylation PhosphoSitePlus
K314 Methylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K315 Acetylation PhosphoSitePlus
K315 Methylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S316 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus   RLIMS-P 26082493
S319 O-Glycosylation PhosphoSitePlus
T322 O-Glycosylation PhosphoSitePlus
S337 O-Glycosylation PhosphoSitePlus
S337 Phosphorylation RLIMS-P 17959673
T352 O-Glycosylation PhosphoSitePlus
S374 O-Glycosylation PhosphoSitePlus
S374 Phosphorylation RLIMS-P 22715377
S377 O-Glycosylation PhosphoSitePlus
T429 Phosphorylation RLIMS-P 22715377
T435 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15073167
S468 Phosphorylation P49841 (GSK3B) , O14920 (IKBKB) , Q14164 (IKBKE) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18439422, 28317833, 23141142, ...15465828, 15280197, 27721021, 20482821, 24063540, 19270718, 25074812, 16046471, 20507904, 17183360, 26460486, 16407239, 24574500, 18201972, 15489227, 26463447
S472 Phosphorylation PhosphoSitePlus
T505 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15775976, 16424027, 15970704
S529 Phosphorylation P68400 (CSNK2A1) , P47710 (CSN1S1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14711835, 10938077, 18922932, ...25862606, 28105499, 20882529, 25620704, 26082493, 18948740, 14963024, 15016307, 24216290, 18243161, 24086494, 21232017, 17008051, 9792644, 22527100
S536 Phosphorylation P51812 (RPS6KA3) , O15111 (CHUK) , O94806 (PRKD3) , Q9Y6K9 (IKBKG) , Q9UHD2 (TBK1) , Q9HCP0 (CSNK1G1) , Q16566 (CAMK4) , Q15418 (RPS6KA1) , Q00534 (CDK6) , O14920 (IKBKB) , P24723 (PRKCH) , Q14164 (IKBKE) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 26165401, 18191107, 24943908, ...15849198, 16919916, 16046471, 17975552, 18771813, 22406367, 15802625, 26246800, 21115974, 15192014, 19303015, 21945666, 16735506, 20805562, 23455325, 24911931, 26613980, 22155370, 16007163, 16105840, 24039253, 17008051, 18477470, 28222108, 23056624, 23064013, 12419817, 17785205, 19073147, 21344491, 24957606, 15531529, 22527100, 25187543, 18627520, 12767944, 16875840, 23383209, 22384180, 23118497, 18657320, 21182083, 16407239, 23408313, 15611068, 20696864, 29378189, 16498455, 11359840, 27221592, 18439422, 21820409, 23619300, 20406326, 22666431, 16382138, 20204068, 23166834, 23666959, 10521409, 28317833, 24690380, 18996613, 26872379, 26463447, 17136479, 14711835, 26375985, 16034126, 15493960, 17953764, 19201908, 20952659, 20484017, 19587216, 24155403, 25240403, 27149922, 20186265, 15561777, 17377595, 15113757, 18056447, 17548605, 24584670, 12759443, 17012367, 15100319, 22382785, 24345501, 25289898, 15485852, 24345643, 21451502, 23593410, 27244888, 26082493, 18729103, 15557193, 20507904, 24216290, 29207489, 16513650, 16840782, 15980040, 29386556, 17223244, 19157506, 23141142, 19706715, 18243161, 25201625, 23696745, 18424071, 29331583, 19201871, 22815798, 29770869, 26826124, 22933966, 20451669, 15611276, 23343403, 25344476, 22081069, 28416608, 17575118, 17595324, 22226621, 23454654, 16477006, 24442433, 17932028, 17397830, 23812431, 28545028, 21630326, 14963024, 28122346, 21816815, 28381553, 28423692, 24582884, 25974126, 26729520, 16407467, 21549062, 20410276, 18720410, 23300567, 20850430, 20194077, 22996371, 28466782, 18701687, 24248603, 21228323, 27793942, 22797919, 19746155, 17317104, 18097051, 22634313, 25722974, 22768286, 24063540, 21665565, 23269273, 23056468, 26455386, 22102084, 18453612, 23936501, 22641218, 26693062, 15128824, 23016877, 27721021, 24574500, 22842493, 19789307, 27555662, 27329558, 27745655, 25197166, 27466442, 16261446, 15489227, 24586253, 25114952, 20484867, 26460486, 23468625
S543 Phosphorylation P68400 (CSNK2A1) Signor 10938077
S547 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P+   RLIMS-P 22715377
Site PTM Type PTM Enzyme Score Source PMID
K122 Acetylation PR:Q09472 (hEP300) , PR:Q92831 (hKAT2B) PRO 12419806
K123 Acetylation PR:Q09472 (hEP300) , PR:Q92831 (hKAT2B) PRO 12419806
S276 Phosphorylation P17612 (PRKACA) HPRD 9150141, 9660950
K310 Acetylation PR:Q09472 (hEP300) PRO 20064247
S311 Phosphorylation Q05513 (PRKCZ) HPRD 12881425
K314 Acetylation PR:Q09472 (hEP300) PRO 20064247
K315 Acetylation PR:Q09472 (hEP300) PRO 20064247
S536 Phosphorylation O15111 (CHUK) HPRD 12842894
S543 Phosphorylation P68400 (CSNK2A1) HPRD 10938077


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049038 (hRELA/Phos:2) pS276 PRO
PR:000027918 (hRELA/iso:1/Ac:1) acK310,acK314,acK315 PR:Q09472 (hEP300) PRO 20064247
PR:000027920 (hRELA/iso:1/Ac:2) acK122,acK123 PR:Q09472 (hEP300) PRO 12419806
PR:000027920 (hRELA/iso:1/Ac:2) acK122,acK123 PR:Q92831 (hKAT2B) PRO 12419806


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q04206 (RELA) S276 Q09472 (EP300) inhibited_association eFIP 27679610
Phosphorylation Q04206 (RELA) S536 Q99988 (GDF15) decreased_association eFIP 27745655
Phosphorylation Q04206 (RELA) S276 Q04863 (Relb) unknown eFIP 20686703
Phosphorylation Q04206 (RELA) S547 Q13547 (HDAC1) unknown eFIP 22715377
Phosphorylation Q04206 (RELA) S536 Q13148 (TARDBP) unknown eFIP 24690380
Phosphorylation Q04206 (RELA) S276 P26358 (DNMT1) unknown eFIP 21765477


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q04206 (hRELA) PRO 16291753


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S131 T131 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R174 H174 Biomuta DOID:363 / uterine cancer [ tcga ]
R174 C174 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R187 C187 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S276 F276 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T308 A308 Biomuta DOID:1324 / lung cancer [ tcga ]
T429 P429 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T505 K505 Biomuta DOID:3571 / liver cancer [ icgc ]
S529 L529 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]