Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03468 / ERCC6_HUMAN
Protein Name DNA excision repair protein ERCC-6
Gene Name Name: ERCC6
Synonyms:CSB;
Organism Homo sapiens (Human)

PRO ID PR:Q03468
DAG View
PRO Name DNA excision repair protein ERCC-6 (human)
Definition A DNA excision repair protein ERCC-6 that is encoded in the genome of human.
Short Label hERCC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03468 (ERCC6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S10 Phosphorylation PhosphoSitePlus   UniProt 29203878
K32 Sumoylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
C61 S-Nitrosylation dbSNO 26338901
S124 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S158 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...29203878, 18669648, 20068231
K170 Methylation PhosphoSitePlus   UniProt 18438403
S173 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
K262 Sumoylation PhosphoSitePlus
K297 Methylation PhosphoSitePlus   UniProt 18438403
T303 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S429 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S430 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
K448 Methylation PhosphoSitePlus   UniProt 18438403
S486 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 16565220
S489 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 16565220
S624 Phosphorylation PhosphoSitePlus
Y625 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
S893 Phosphorylation PhosphoSitePlus
Y932 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 17626041
K955 Ubiquitination PhosphoSitePlus
S1009 Phosphorylation phospho.ELM 18669648
K1054 Methylation PhosphoSitePlus   UniProt 18438403
S1142 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1146 Phosphorylation PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
S1189 Phosphorylation PhosphoSitePlus
K1198 Ubiquitination PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus
K1258 Ubiquitination PhosphoSitePlus
S1276 Phosphorylation PhosphoSitePlus
Y1279 Phosphorylation PhosphoSitePlus
K1295 Ubiquitination PhosphoSitePlus
S1337 Phosphorylation PhosphoSitePlus
S1340 Phosphorylation PhosphoSitePlus
S1345 Phosphorylation PhosphoSitePlus
S1346 Phosphorylation PhosphoSitePlus
T1347 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1348 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T1350 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1352 Ubiquitination PhosphoSitePlus
K1359 Ubiquitination PhosphoSitePlus
K1363 Ubiquitination PhosphoSitePlus
S1381 Phosphorylation PhosphoSitePlus
K1392 Ubiquitination PhosphoSitePlus
K1457 Ubiquitination PhosphoSitePlus
S1461 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K1487 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S124 Phosphorylation HPRD 20068231
S158 Phosphorylation HPRD 18691976, 16964243, 19007248, ...18452278, 18669648, 17924679, 19415658, 20068231, 19691289
S429 Phosphorylation HPRD 18669648, 18452278
S430 Phosphorylation HPRD 18669648, 17081983, 18452278
S438 Phosphorylation HPRD 17081983
S486 Phosphorylation HPRD 18669648, 16565220, 20068231, ...18452278
S489 Phosphorylation HPRD 18669648, 16565220, 20068231, ...18452278
S893 Phosphorylation HPRD 18452278
S1009 Phosphorylation HPRD 18669648
S1142 Phosphorylation HPRD 19413330, 18669648
S1345 Phosphorylation HPRD 20068231
T1347 Phosphorylation HPRD 18669648, 20068231
S1348 Phosphorylation HPRD 18669648, 20068231, 18452278
T1350 Phosphorylation HPRD 18669648
S1461 Phosphorylation HPRD 17525332


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047325 (hERCC6/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T303 A303 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S430 P430 Biomuta DOID:10534 / stomach cancer [ tcga ]
K663 E663 Biomuta DOID:1909 / melanoma [ cosmic ]
K759 N759 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K820 N820 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S893 * Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S1146 I1146 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1146 T1146 Biomuta DOID:1612 / breast cancer [ icgc, tcga ]
K1258 N1258 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1345 L1345 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K1352 N1352 Biomuta DOID:363 / uterine cancer [ tcga ]
K1359 E1359 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K1487 * Biomuta DOID:9256 / colorectal cancer [ tcga ]