iPTMnet Report for Q03431 (PTH1R)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03431 / PTH1R_HUMAN
Protein Name Parathyroid hormone/parathyroid hormone-related peptide receptor precursor
Gene Name Name: PTH1R
Synonyms:PTHR,PTHR1;
Organism Homo sapiens (Human)

PRO ID PR:Q03431
DAG View
PRO Name parathyroid hormone/parathyroid hormone-related peptide receptor (human)
Definition A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human.
Short Label hPTH1R
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03431 (PTH1R) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y23 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus   RLIMS-P 27623777
S91 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
Y320 Phosphorylation PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus   RLIMS-P 29444827
K388 Ubiquitination PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus   RLIMS-P 29444827
S473 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus   RLIMS-P 11773434
S492 Phosphorylation PhosphoSitePlus   RLIMS-P 11773434
S493 Phosphorylation PhosphoSitePlus   RLIMS-P 11773434
Y494 Phosphorylation PhosphoSitePlus
S495 Phosphorylation RLIMS-P 11773434
Y496 Phosphorylation PhosphoSitePlus
S501 Phosphorylation RLIMS-P 11773434
T503 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus   RLIMS-P 11773434
S519 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
T551 Phosphorylation PhosphoSitePlus   UniProt 24275569
T591 Phosphorylation RLIMS-P 28376304


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y320 F320 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S491 R491 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S493 N493 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T503 K503 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T547 N547 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T547 I547 Biomuta DOID:4159 / skin cancer [ cosmic ]